Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jiajiu, Shaw"'
Autor:
Junning Zhao, Tianmin Yuan, shilong chen, yifeng Yin, Jiajiu Shaw, Jin Zeng, Li Li, Lei Song, Yiguan Zhang, Zhujun Yin
Publikováno v:
Current Pharmaceutical Biotechnology. 24
Background: Gouty arthritis (GA) is a common form of inflammatory arthritis caused by intra-articular deposition of monosodium urate (MSU) crystals; however, there is a tremendous lack of safe and effective therapy in the clinic. Objective: The goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8669e17c42147fa1dfc13cf21250c395
https://doi.org/10.2174/1389201024666230420101219
https://doi.org/10.2174/1389201024666230420101219
Autor:
Tyler A. Johnson, David Coppage, Jiajiu Shaw, Phillip Crews, Joseph Media, Marcos A. Ogarrio, Frederick A. Valeriote, Erin P. McCauley, Joseph D. Morris, Lauren N Persi, Mani Maheshwari, Taylor C Garcia, Nicole L. McIntosh, Colon V. Cook
Publikováno v:
ACS Medicinal Chemistry Letters. 11:108-113
Reinvestigation of mycothiazole (1) revealed picomolar potency (IC50 = 0.00016, 0.00027, 0.00035 μM) against pancreatic, (PANC-1), liver (HepG2), and colon (HCT-116) tumor cell lines. Reevaluation of 1 provided [α]D data indicating Vanuatu specimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25064717cf5b9545371be28eab12d710
https://doi.org/10.1021/acsmedchemlett.9b00302
https://doi.org/10.1021/acsmedchemlett.9b00302
Autor:
Xiaohua Gao, Nicholas J. Carruthers, Jiajiu Shaw, Subhash C Guatam, Ben Chen, Frederick A. Valeriote, Paul M. Stemmer
Publikováno v:
European Journal of Pharmacology. 811:66-73
UTL-5g is a novel small-molecule TNF-alpha modulator. It reduces cisplatin-induced side effects by protecting kidney, liver, and platelets, thereby increasing tolerance for cisplatin. UTL-5g also reduces radiation-induced acute liver toxicity. The me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a63b379ed98a7c70d66ddedbebac6e
https://doi.org/10.1016/j.ejphar.2017.05.049
https://doi.org/10.1016/j.ejphar.2017.05.049
Autor:
Jiajiu Shaw, Subhash C. Gautam, Dorrah Deeb, Xiaohua Gao, Yiguan Zhang, Yong Bo Liu, Frederick A. Valeriote
Publikováno v:
Oncology Reports. 37:1914-1920
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c4ec7d3200c493e2e8dcf0c141bccf
https://doi.org/10.3892/or.2017.5400
https://doi.org/10.3892/or.2017.5400
Autor:
Tyler A, Johnson, Joseph D, Morris, David A, Coppage, Colon V, Cook, Lauren N, Persi, Marcos A, Ogarrio, Taylor C, Garcia, Nicole L, McIntosh, Erin P, McCauley, Joseph, Media, Mani, Maheshwari, Frederick A, Valeriote, Jiajiu, Shaw, Phillip, Crews
Publikováno v:
ACS Med Chem Lett
[Image: see text] Reinvestigation of mycothiazole (1) revealed picomolar potency (IC(50) = 0.00016, 0.00027, 0.00035 μM) against pancreatic, (PANC-1), liver (HepG2), and colon (HCT-116) tumor cell lines. Reevaluation of 1 provided [α](D) data indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b1a8892b1d427a8ed885846904f2b15
https://pubmed.ncbi.nlm.nih.gov/32071675
https://pubmed.ncbi.nlm.nih.gov/32071675
Autor:
Yiguan Zhang, Yongxin Tang, Ben Chen, Frederick Valeriote, Subhash Gautam, Xiaohua Gao, Jiajiu Shaw
Publikováno v:
American Journal of Biomedical Sciences. :228-236
UTL-5g is a small-molecule TNF-α modulator that is anti-inflammatory in a carrageenan-induced edema animal model and chemoprotective against anticancer drug-induced side effects. Recently, it was shown that UTL-5g is a prodrug and its active metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947f2bf659b10165ced6f64eab78840f
https://doi.org/10.5099/aj160300228
https://doi.org/10.5099/aj160300228
Autor:
Jiajiu Shaw, Subhash C. Gautam, Yiguan Zhang, Xiaohua Gao, Dorrah Deeb, Yongbo Liu, Frederic K A Valeriote
Publikováno v:
International Journal of Oncology. 49:1139-1147
Pancreatic ductal adenocarcinoma (PDA) remains one of the most difficult to treat of all malignancies. Multimodality regimens provide only short-term symptomatic improvement with minor impact on survival, underscoring the urgent need for novel therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070ad3f530ae488cc453c1bdb550f7d8
https://doi.org/10.3892/ijo.2016.3587
https://doi.org/10.3892/ijo.2016.3587
Autor:
Xiaojuan Wang, Ken Swartz, Paul M. Stemmer, Mark T. Hamann, Jiajiu Shaw, Nicholas J. Carruthers, Frederick A. Valeriote, Joe Media, Nicholas Aube
Publikováno v:
J Proteomics
Methicillin-resistant S aureus (MRSA) contributes to patient mortality and extended hospital stays. 3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR) is a natural product antibiotic that is effective against MRSA but has no known mechanism of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3435a1788efeae785c8f18b1e044245f
https://doi.org/10.1016/j.jprot.2019.103539
https://doi.org/10.1016/j.jprot.2019.103539
Autor:
Xiaohua Gao, Subhash C. Gautam, Dorrah Deeb, Yiguan Zhang, Yongbo Liu, Patricia Liu, Jiajiu Shaw
Publikováno v:
International Journal of Oncology
Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) has shown potent antitumorigenic activity against a wide range of cancer cell lines in vitro and inhibited the growth of liver, lung and prostate cancer in vivo. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3c977845758b86d1ade98fc451a341
https://doi.org/10.3892/ijo.2015.3212
https://doi.org/10.3892/ijo.2015.3212
Publikováno v:
American Journal of Biomedical Sciences. :1-8
UTL-5g is a novel small-molecule chemoprotective agent against cisplatin-induced host cytotoxicity. Recent studies showed that UTL-5g increased the blood platelet count, which was reduced in cisplatintreated mice. In order to have a better understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fa850de54ecca8c957e7935a5702d9
https://doi.org/10.5099/aj150100001
https://doi.org/10.5099/aj150100001