Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Jiajie Tu"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Immune cell therapy based on chimeric antigen receptor (CAR) technology platform has been greatly developed. The types of CAR immune cell therapy have expanded from T cells to innate immune cells such as NK cells and macrophages, and the dis
Externí odkaz:
https://doaj.org/article/da61a9fb9ce54275b13d2b23581fa64f
Autor:
Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu, Wei Wei, Jiajie Tu
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor micro
Externí odkaz:
https://doaj.org/article/c317b590ec954374a17091602bc4bc14
Publikováno v:
Sensors, Vol 24, Iss 9, p 2950 (2024)
Multi-layer complex structures are widely used in large-scale engineering structures because of their diverse combinations of properties and excellent overall performance. However, multi-layer complex structures are prone to interlaminar debonding da
Externí odkaz:
https://doaj.org/article/abb88e7c60914dc1be653496d4ff8d52
Autor:
Adrian On-Wah Leung, Tsz-Ching Yiu, Lingxiao Liu, Hei-Yin Tam, Shen Gu, Jiajie Tu, Duanqing Pei, Hoi-Hung Cheung
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Background Pathogenic mutations in WRN are a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skeletal system, charac
Externí odkaz:
https://doaj.org/article/2c50e11b7a0f437dae7d409b46668504
Autor:
Jiajie Tu, Dafei Han, Yilong Fang, Haifeng Jiang, Xuewen Tan, Zhen Xu, Xinming Wang, Wenming Hong, Tao Li, Wei Wei
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 733-750 (2022)
Rheumatoid arthritis (RA) is an inflammation-involved disorder and features the disruption of CD4+ T lymphocytes. Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4+ T cells. Mi
Externí odkaz:
https://doaj.org/article/4fc9d5440592488481a719618e8520c0
Autor:
Yilong Fang, Weile Chen, Zhe Li, Yu Chen, Xuming Wu, Xiangling Zhu, Huihui Wang, Xiaochun Chen, Qiuni Liang, Jinghua Huang, Xintong Han, Wenming Hong, Xinming Wang, Wei Wei, Zhiying Yu, Jiajie Tu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
PU.1, a transcription factor member of the E26 transformation-specific family, affects the function of a variety of immune cells in several physiological and pathological conditions. Previous studies studying the role of PU.1 in pathological conditio
Externí odkaz:
https://doaj.org/article/4709e37f30994f05990570ce1b8af0b0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rheumatoid arthritis (RA) is a chronic autoimmune disease that endangers the health of approximately 1% of the global population. Current RA medications on the market mainly include non-steroidal anti-inflammatory drugs, biological agents, and diseas
Externí odkaz:
https://doaj.org/article/e81757272fe6476ebc2a8abd0ec2b5b6
Autor:
Jiawei Zhang, Xianzheng Zhang, Mingdian Lu, Yan Chang, Qingtong Wang, Jiajie Tu, Huaxun Wu, Chun Wang, Zhongyang Hong, Maoming Xiong, Lihua Song, Wei Wei
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 664 (2023)
G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage po
Externí odkaz:
https://doaj.org/article/5046fed2f99e42a4bcb80307f4fe0ca4
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 1107-1120 (2020)
Synovitis refers to the inflammation of the synovial membrane and is commonly detected in patients with osteoarthritis (OA). Recent reports have suggested that microRNAs (miRNAs) could be a promising target for diagnosis and prognosis in OA. This stu
Externí odkaz:
https://doaj.org/article/209a41f8fdae41ac9c027f0ac39e3c79
Publikováno v:
Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are essential for folliculogenesis. Pathological changes in GCs are found in several ovarian disorders. Recent reports have indicated that long non-coding RNAs
Externí odkaz:
https://doaj.org/article/d854b7a1285b44cf92cb1680f0d983c5