Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Jiajia Mou"'
1
Akademický článek
Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds
Autor: Lanlan Fu, Jiajia Mou, Yanru Deng, Xiaoliang Ren, Shuang Qiu
Publikováno v: Frontiers in Chemistry, Vol 10 (2022)
Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of
Externí odkaz: https://doaj.org/article/2ed35f22a3df4d4eb7435e8b7736753a
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2
Akademický článek
Structural modifications of berberine and their binding effects towards polymorphic deoxyribonucleic acid structures: A review
Autor: Lanlan Fu, Jiajia Mou, Yanru Deng, Xiaoliang Ren
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Berberine (BBR) is a plant derived quaternary benzylisoquinoline alkaloid, which has been widely used in traditional medicines for a long term. It possesses broad pharmacological effects and is widely applied in clinical. In recent years, the anti-tu
Externí odkaz: https://doaj.org/article/eeb92066c2a84b1ba407b33dd001438a
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3
Insight on Structural Modification, Cytotoxic or Anti-Proliferative Activity, Structure-Activity Relationship of Berberine Derivatives
Autor: Jiajia Mou, Mengxuan Yin, Lili Sun, Yanru Deng, Xiaoliang Ren
Publikováno v: Medicinal Chemistry. 19
Background: Berberine (BBR) is a quaternary ammonium alkaloid isolated from the Traditional Chinese Medicine Coptis chinensis. It possesses a plethora of pharmacological activities because its unique structure properties make it readily interact with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f343203395b6ef1c24fe91a6e0aa997f
https://doi.org/10.2174/1573406419666230403120956
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6
Design, synthesis, and primary activity assays of baicalein derivatives as cyclin‐dependent kinase 1 inhibitors
Autor: Teka Tekleab, Shuang Qiu, Yanru Deng, Jiajia Mou, Danghui Chen
Publikováno v: Chemical Biology & Drug Design. 98:639-654
Malignant tumor is a disease with high mortality. Traditional treatment methods have many disadvantages, such as side effects, drug resistance and so on. Because cyclin-dependent kinase 1 (CDK1) plays an indispensable role in cell cycle regulation, i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee7dc60a2a3349898f696fdf5cd7693
https://doi.org/10.1111/cbdd.13917
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7
Comparative study on the stability/intestinal absorption kinetics of 2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside derived from Polygoni Multiflori Radix and its herb pairs
Autor: Meng Wang, Jiajia Mou, Lili Sun, Tao Feng, Guangjiao You, Zhang Huijie, Xiaoliang Ren
Publikováno v: Journal of Liquid Chromatography & Related Technologies. 44:490-500
The 2,3,5,4’-tetrahydroxy-stilbene-2-O-β-D-glucoside (THSG) is a main active ingredient of Polygoni Multiflori Radix (PMR). In this study, THSG was found to be a differential chemical composition b...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a2c37c3040d77713162074444a2b719
https://doi.org/10.1080/10826076.2021.1966441
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8
Characteristic profiling of Aconiti Lateralis Radix for distinguishing it from compatible herbal pair using UPLC–Q‐TOF–MS coupled with chemometrics
Autor: Huanhuan Li, Meng Wang, Fuxiang Zheng, Guangjiao You, Lili Sun, Xiaoliang Ren, Yanan Liu, Jiajia Mou
Publikováno v: Biomedical Chromatography. 36
A method combining ultra-high-performance liquid chromatograph/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and chemometrics was established to evaluate the differences in chemical composition between Aconiti Lateralis Radix (Fuzi in C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920c1589ba5cb8032466811b29518c60
https://doi.org/10.1002/bmc.5256
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9
Polygonum multiflorum: Recent updates on newly isolated compounds, potential hepatotoxic compounds and their mechanisms
Autor: Guixiang Pan, Jian Gao, Tekleab Teka, Haiyang Yu, Jiajia Mou, Li-Ming Wang, Lifeng Han, Xiumei Gao
Publikováno v: Journal of ethnopharmacology. 271
Ethnopharmacological relevance Polygonum multiflorum Thunb.(PM), (known as Heshouwu (何首乌) in China) is one of the most important and well mentioned Chinese medicinal herbs in the literature for its use in blackening hair, nourishing liver and k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc162176b836e94886911c415d3c4cc5
https://pubmed.ncbi.nlm.nih.gov/33485980
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10
Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation
Autor: Qiang Wang, Jiajia Mou, Danghui Chen, Yepeng Luan
Publikováno v: Medicinal Chemistry Research. 26:3015-3025
Considering the important roles played in tumor, aminopeptidase N has been an appealing target for anti-tumor drug development. Here, a serial of novel aminopeptidase N inhibitors with L-arginine scaffold were designed, synthesized and evaluated for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77deca7e6a1b805b80973340b63cb397
https://doi.org/10.1007/s00044-017-1999-2
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