Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jia-Zhao Xie"'
Autor:
Xin Wang, Qian Liu, Hai-tao Yu, Jia-zhao Xie, Jun-ning Zhao, Zhi-ting Fang, Min Qu, Yao Zhang, Ying Yang, Jian-Zhi Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/0b78d85f2ec4455bb98356fcd1f1bdc8
Autor:
Xin Wang, Qian Liu, Hai-tao Yu, Jia-zhao Xie, Jun-ning Zhao, Zhi-ting Fang, Min Qu, Yao Zhang, Ying Yang, Jian-Zhi Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β (IDH3β) levels, a critical t
Externí odkaz:
https://doaj.org/article/22e1bd0e6c8343b5b706b6eaa267e54b
Autor:
Jia‐Zhao Xie, Yao Zhang, Shi‐Hong Li, Hui Wei, Hui‐Ling Yu, Qiu‐Zhi Zhou, Lin‐Yu Wei, Dan Ke, Qun Wang, Ying Yang, Jian‐Zhi Wang
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Abstract Background Human Tau (hTau) accumulation and synapse loss are two pathological hallmarks of tauopathies. However, whether and how hTau exerts toxic effects on synapses remain elusive. Methods Mutated hTau (P301S) was overexpressed in the N2a
Externí odkaz:
https://doaj.org/article/637026b5410d440c99515a2c36a9eb46
Autor:
Ji Zeng, Xiaochuan Wang, Hui Wei, Hui-Liang Zhang, Dan Ke, Jia-Zhao Xie, Dong-Li Meng, Rong Liu
Publikováno v:
Current Medical Science. 40:1-8
SummaryProtein phosphatase 2A (PP2A) is a major serine/threonine phosphatase which participates in the regulation of multiple cellular processes. As a confirmed tumor suppressor, PP2A activity is downregulated in tumors and its re-activation can indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee7ff521ab92607054d8d94397e5e546
https://doi.org/10.1007/s11596-020-2140-1
https://doi.org/10.1007/s11596-020-2140-1
Autor:
Shu-Fang Zhang, Hua-Min Chen, Jia-Ni Xiong, Jun Liu, Jie Xiong, Jia-zhao Xie, Xiao-Ming Wang, Qing Tian, Bin Xia, Yi Li, Na Qu
Publikováno v:
Journal of psychiatric research. 150
Cognitive impairments is one of important accompanied symptom in Unipolar depressive disorder (UD) and bipolar disorder (BD) that was hard to distinguish, as their diagnosis is based on behavioural observations and subjective symptoms. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb68695b483d6c1563db16bab601f32
https://pubmed.ncbi.nlm.nih.gov/35429740
https://pubmed.ncbi.nlm.nih.gov/35429740
Autor:
Shu-Fang Zhang, Jia-Zhao Xie, Na Ren, Yi Li, Wang Yan, Qing Tian, Jie Xiong, Na Qu, Xiao-Ming Wang, Bin Xia, Liu Jun
Publikováno v:
Journal of Clinical Neuroscience. 70:14-19
Cognitive dysfunction and pro-inflammatory effect has been associated with major depressive disorder (MDD), but sex differences have seldom been studied. The study was to determine the sex difference of cognitive dysfunction and pro-inflammatory biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27214f3fdc68957255fe3bffecca354
https://doi.org/10.1016/j.jocn.2019.10.002
https://doi.org/10.1016/j.jocn.2019.10.002
Autor:
Xiang-Yang Xu, Yao Zhang, Teng Xu, Jun Hu, Shao-Juan Yang, Si Jin, Jian-Zhi Wang, Jia-Zhao Xie
Publikováno v:
Neurosci Bull
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer’s disease (AD), and insulin-resistance is commonly seen in patients with Hhcy. Liraglutide (Lir), a glucagon-like peptide that increases the secretion and sensitivity of insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87848eeac058833b34db006022e139cb
https://doi.org/10.1007/s12264-018-00336-7
https://doi.org/10.1007/s12264-018-00336-7
Autor:
Rong Liu, Dong-Li Meng, Hui-Liang Zhang, Dan Ke, Xiaochuan Wang, Hui Wei, Ji Zeng, Jia-Zhao Xie
Publikováno v:
Current Medical Science
The article “Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer’s Disease”, written by Hui WEI, Hui-liang ZHANG, Jia-zhao XIE, Dong-li MENG, Xiao-chuan WANG, Dan KE, Ji ZENG, Rong LIU, was originally published elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f8f289ca39f81403491a50367cdac5
https://pubmed.ncbi.nlm.nih.gov/32166659
https://pubmed.ncbi.nlm.nih.gov/32166659
Autor:
Hui-Liang Zhang, Jukka Westermarck, Lu Wan, Michael Ohlmeyer, Dan-Dan An, Yi Zeng, Youming Lu, Jia-Zhao Xie, Hui Wei, Xiaochuan Wang, Xiji Shu, Jian-Zhi Wang, Rong Liu
Publikováno v:
Neurotherapeutics
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease for which there are limited therapeutic strategies. Protein phosphatase 2A (PP2A) activity is decreased in AD brains, which promotes the hyperphosphorylation of Tau and APP, thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b741c4e78ec49c47ff56f0ec55da32fb
https://pubmed.ncbi.nlm.nih.gov/32096091
https://pubmed.ncbi.nlm.nih.gov/32096091
Autor:
Jian-Zhi Wang, Xiang-Shu Cheng, Xin-Wen Zhou, Xiao-Hong Li, Fan-Li Kong, Lai-Ling Du, Chen Chen, Zhi-Wei Ma, Xia Jiang, Jia-Zhao Xie
Publikováno v:
AGE. 36:613-623
Patients with diabetes in the aging population are at high risk of Alzheimer's disease (AD), and reduction of sirtuin 1 (SIRT1) activity occurs simultaneously with the accumulation of hyperphosphorylated tau in the AD-affected brain. It is not clear,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4ccfce07254acf28a962ab90c07fc
https://doi.org/10.1007/s11357-013-9592-1
https://doi.org/10.1007/s11357-013-9592-1