Výsledky vyhledávání - "Jia-Yu Chang"

Akademický článek

COE targets EphA2 to inhibit vasculogenic mimicry formation induced by hypoxia in hepatocellular carcinoma

Autor: Jue Chen, Shu-Ying Dai, Su Wu, Meng-Ke Wu, Ke-Ke Yu, Jun-Chi Liu, Jia-Yu Chang, Yan-Qing Liu

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

BackgroundVasculogenic Mimicry (VM) can reduce the efficacy of anti-angiogenesis and promote distant metastasis in hepatocellular carcinoma (HCC). Our previous studies have found that Celastrus orbiculatus extract (COE) can inhibit the VM formation i

Externí odkaz: https://doaj.org/article/621d7aca09204b3cbb3e15ae52b0b4eb

Zobrazit plný text záznamu

Akademický článek

Inhalable chitosan-based hydrogel as a mucosal adjuvant for hydroxychloroquine in the treatment for SARS-CoV-2 infection in a hamster model

Autor: Donna Shu-Han Lin, Shian Chiuan Tzeng, Tai-Lung Cha, Chin-Mao Hung, Wen-Chin Lin, Chuen-Mi Yang, Hsuan-Ying Lu, Jia-Yu Chang, Shu-Wei Huang

Publikováno v: Journal of Microbiology, Immunology and Infection, Vol 56, Iss 5, Pp 951-960 (2023)

Background: Effective therapy for COVID-19 remains limited. Hydroxychloroquine (HCQ) has been considered, but safety and efficacy concerns remain. Chitosan exhibits antiviral and immunomodulatory effects, yet how the combination of HCQ and chitosan p

Externí odkaz: https://doaj.org/article/9e594e49ab0d42febcbae9f5b98037aa

Zobrazit plný text záznamu

Akademický článek

A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-18 (2022)

Abstract The emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) variants has altered the trajectory of the COVID‐19 pandemic and raised some uncertainty on the long‐term efficiency of vaccine strategy. The development

Externí odkaz: https://doaj.org/article/b59c23cca78f41b498973507e9a76ace

Zobrazit plný text záznamu

Akademický článek

Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19

Autor: Chi-Ju Hsu, Wen-Chin Lin, Yu-Ching Chou, Chuen-Mi Yang, Hsueh-Ling Wu, Yun-Hsiang Cheng, Ping-Cheng Liu, Jia-Yu Chang, Hsing-Yu Chen, Jun-Ren Sun

Publikováno v: Microbiology Spectrum, Vol 10, Iss 1 (2022)

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 2019 (COVID-19). However, the long-term health consequences of COVID-19 are not fully understood. We aimed to determine the l

Externí odkaz: https://doaj.org/article/efac7a38d41748acb87a7eb12c73d828

Zobrazit plný text záznamu

On-board BDS dynamic filtering ballistic determination and precision evaluation

Autor: Shu-Qiang Zhao, Jia-Yu Chang

Publikováno v: Open Astronomy. 31:340-347

BeiDou navigation satellite system (BDS) receivers on-board cannot give real-time positioning precision in tracking missile and carrier rocket. In this article, the dynamic filtered optimal estimation theory is applied to the highly dynamic on-board

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad952c649e6fd93c6aba62718ff04e9a
https://doi.org/10.1515/astro-2022-0193

Zobrazit plný text záznamu

Crystal structure of (E)-2-((Z)-2-((1S,4R)-3,3-dimethylbicyclo[2.2.1] heptan-2-ylidene)ethylidene)hydrazine-1-carbothioamide, C24H38N6S2

Autor: Jia-Yu Chang, Qing-Ying Ding, Zhuan-Quan Xiao, Ji Zhang, Shang-Xing Chen

Publikováno v: Zeitschrift für Kristallographie - New Crystal Structures. 238:341-342

[C24H38N6S2], triclinic, P 1 ‾ $P\overline{1}$ (no. 2), a = 5.9953(4) Å, b = 7.6132(5) Å, c = 15.3709(10) Å, α = 82.089(5)°, β = 88.307(6)°, γ = 75.992(6)°, V = 674.24(8) Å3, Z = 1, R gt(F) = 0.0587, wR ref(F 2) = 0.1516, T = 296(2) K.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2af795a48c141cad54dc2767c34f099
https://doi.org/10.1515/ncrs-2023-0011

Zobrazit plný text záznamu

Programmed cell death 1 pathway inhibitors improved overall survival of small cell lung cancer patients with brain metastases

Autor: Jia yu chang, Xu Quan Jing, Hua Ying, Kai Xing Geng, Ru Yue Li, ShuangQing Lu, Hui Zhu, Yan Zhang

Purpose The objective of this study was to evaluate the safety and efficacy of immune checkpoint inhibitors applied in the small cell lung cancer patients with brain metastases. Methods We retrospectively reviewed the records of small cell lung cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82fd51f72a8213655698250994631e4f
https://doi.org/10.21203/rs.3.rs-1421720/v1

Zobrazit plný text záznamu

Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

Publikováno v: Journal of Medicinal Chemistry. 63:1642-1659

Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be useful in cancer immunotherapy, but a phase III clinical trial of the most advanced IDO1 inhibitor, epacadostat, did not meet its primary end point and was abandoned. In previous work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4258e7674e4456ad315cdaea64c49e02
https://doi.org/10.1021/acs.jmedchem.9b01549

Zobrazit plný text záznamu

Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants

Publikováno v: Journal of Medicinal Chemistry. 62:3940-3957

Drug resistance due to acquired mutations that constitutively activate c-KIT is a significant challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). Herein, we identified 1-(5-ethyl-isoxazol-3-yl)-3-(4-{2-[6-(4-ethylpipe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01c2cdf54c196cc57b9d74b4e146ba3
https://doi.org/10.1021/acs.jmedchem.8b01845

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání