Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome

Autor: Shao-Ling Chu, Jia-Rong Huang, Yu-Tzu Chang, Shu-Yun Yao, Jia-Shu Yang, Victor W. Hsu, Jia-Wei Hsu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract The epidermal growth factor receptor (EGFR) plays important roles in multiple cellular events, including growth, differentiation, and motility. A major mechanism of downregulating EGFR function involves its endocytic transport to the lysosom

Externí odkaz: https://doaj.org/article/18a86c233883442994380bf095186c8f

The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol

Autor: Seung-Yeol Park, Jia-Shu Yang, Zhen Li, Pan Deng, Xiaohong Zhu, David Young, Maria Ericsson, Ruben L. H. Andringa, Adriaan J. Minnaard, Chunmei Zhu, Fei Sun, D. Branch Moody, Andrew J. Morris, Jun Fan, Victor W. Hsu

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Phosphatidic acid and diacylglycerol are required for COPI vesicle fission. Here, the authors find that shorter forms of these lipids promote the late stage of COPI vesicle fission, further suggesting how lipid geometry contributes to membrane deform

Externí odkaz: https://doaj.org/article/b2379516ce72461c865a7a7a024c6752

GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

Autor: Petra Henklein, Victor W. Hsu, Alberto Luini, Giovanni D'Angelo, Julian Nüchel, Domenico Russo, Marinella Pirozzi, Takahiro Nitta, Charlotte Gehin, Mukund Thattai, Seetharaman Parashuraman, Ansuman Biswas, María José Hernández-Corbacho, Gabriele Turacchio, Markus Plomann, Nina A. Dathan, Prathyush Pothukuchi, Giovanna Vanacore, Ilenia Agliarulo, Jin-ichi Inokuchi, Lina M. Obeid, Laura Capolupo, Jia-Shu Yang, Yusuf A. Hannun, Riccardo Rizzo

Publikováno v: EMBO journal
40 (2021). doi:10.15252/embj.2021107766
info:cnr-pdr/source/autori:Pothukuchi, Prathyush; Agliarulo, Ilenia; Pirozzi, Marinella; Rizzo, Riccardo; Russo, Domenico; Turacchio, Gabriele; Nüchel, Julian; Yang, Jia Shu; Gehin, Charlotte; Capolupo, Laura; Hernandez-Corbacho, Maria Jose; Biswas, Ansuman; Vanacore, Giovanna; Dathan, Nina; Nitta, Takahiro; Henklein, Petra; Thattai, Mukund; Inokuchi, Jin Ichi; Hsu, Victor W.; Plomann, Markus; Obeid, Lina M.; Hannun, Yusuf A.; Luini, Alberto; D'Angelo, Giovanni; Parashuraman, Seetharaman/titolo:GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis/doi:10.15252%2Fembj.2021107766/rivista:EMBO journal (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
The EMBO Journal

The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific cisternae along the cis‐trans axis of the organelle. How such com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd1becd54d4aca9c4480048a376a2e1
https://doi.org/10.15252/embj.2021107766

Accurate electronic properties and non-linear optical response of two-dimensional MA2Z4

Autor: Hongsheng Liu, Maodu Chen, Luneng Zhao, Jijun Zhao, Shi-Qi Li, Lu Wang, Jia-Shu Yang, Junfeng Gao

Publikováno v: Nanoscale. 13(10)

Two-dimensional MA2Z4 (M = Mo, W, V, Nb, Ta, Ti, Zr, Hf, or Cr; A = Si or Ge; Z = N, P, or As) is a new lead in the 2D family, because it exhibits versatile properties by tuning the components M, A and Z. However, theoretical studies on MA2Z4 are qui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75d3deee51651b33d55834f43935f1a
https://pubmed.ncbi.nlm.nih.gov/33687047

Regulated compartmentalization of enzymes in Golgi by GRASP55 controls cellular glycosphingolipid profile and function

Autor: Victor W. Hsu, Julian Nüchel, Gabriele Turacchio, Seetharaman Parashuraman, Ansuman Biswas, María José Hernández-Corbacho, Markus Plomann, Prathyush Pothukuchi, Alberto Luini, Jin-ichi Inokuchi, Vanacore G, Nina A. Dathan, Gehin Cjc, Yusuf A. Hannun, Ilenia Agliarulo, Laura Capolupo, Giovanni D'Angelo, Petra Henklein, Lina M. Obeid, Jia-Shu Yang, Mukund Thattai, Domenico Russo, Marinella Pirozzi, Takahiro Nitta, Renata Rizzo

Glycans are important regulators of cell and organismal physiology. This requires that the glycan biosynthesis be controlled to achieve specific cellular glycan profiles. Glycans are assembled in the Golgi apparatus on secretory cargoes that traverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7454fcb69b8b50a99d787ac236f30f3
https://doi.org/10.1101/2020.05.03.074682