Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jia-Shu Chen"'
Autor:
Keshav Goel, Mark Keezer, Alexander G Weil, Aria Fallah, Anne Gallagher, Farbod Niazi, Jia-Shu Chen, Aristides Hadjinicolaou
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Hypothalamic hamartomas (HHs) are deep-seated congenital lesions that typically lead to pharmacoresistant epilepsy and a catastrophic encephalopathic syndrome characterised by severe neuropsychological impairment and decline in quality o
Externí odkaz:
https://doaj.org/article/8ff0a00a24f04151a6c288376e14fab9
Autor:
Sami Obaid, Jia‐Shu Chen, George M. Ibrahim, Alain Bouthillier, Evan Dimentberg, Werner Surbeck, Elena Guadagno, Tristan Brunette‐Clément, Nathan A. Shlobin, Aidan Shulkin, Andrew T. Hale, Luke D. Tomycz, Marec Von Lehe, Michael Scott Perry, Francine Chassoux, Viviane Bouilleret, Delphine Taussig, Martine Fohlen, Georg Dorfmuller, Koichi Hagiwara, Jean Isnard, Chima O. Oluigbo, Naoki Ikegaya, Dang K. Nguyen, Aria Fallah, Alexander G. Weil
Publikováno v:
Epilepsia Open, Vol 8, Iss 1, Pp 12-31 (2023)
Abstract Insular epilepsy (IE) is an increasingly recognized cause of drug‐resistant epilepsy amenable to surgery. However, concerns of suboptimal seizure control and permanent neurological morbidity hamper widespread adoption of surgery for IE. We
Externí odkaz:
https://doaj.org/article/85bcda8e79194d649aed912b82a55388
Autor:
Saket Jain, Jonathan W. Rick, Rushikesh S. Joshi, Angad Beniwal, Jordan Spatz, Sabraj Gill, Alexander Chih-Chieh Chang, Nikita Choudhary, Alan T. Nguyen, Sweta Sudhir, Eric J. Chalif, Jia-Shu Chen, Ankush Chandra, Alexander F. Haddad, Harsh Wadhwa, Sumedh S. Shah, Serah Choi, Josie L. Hayes, Lin Wang, Garima Yagnik, Joseph F. Costello, Aaron Diaz, Dieter Henrik Heiland, Manish K. Aghi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF morphology and single-cell transcriptomic profiles based on their la
Externí odkaz:
https://doaj.org/article/14cced134af940a49b4d6fa72e0c4da9
Autor:
Daniele C. Wolf, Nathalie T. Sanon, Alexandra O. S. Cunha, Jia-Shu Chen, Tarek Shaker, Abdul-Rahman Elhassan, Antônia Sâmia Fernandes do Nascimento, Graziella Di Cristo, Alexander G. Weil
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Sexual differentiation of the brain is influenced by testosterone and its metabolites during the perinatal period, when many aspects of brain development, including the maturation of GABAergic transmission, occur. Whether and how testosteron
Externí odkaz:
https://doaj.org/article/708a01107ad54f98a88d85ee5edb2f12
Autor:
Michael M. Safaee, Elaina J. Wang, Saket Jain, Jia-Shu Chen, Sabraj Gill, Allison C. Zheng, Joseph H. Garcia, Angad S. Beniwal, Y. Tran, Alan T. Nguyen, Melissa Trieu, Kevin Leung, Jim Wells, James M. Maclean, Keith Wycoff, Manish K. Aghi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Glioblastoma (GBM) is the most common primary brain tumor with a median survival under two years. Using in silico and in vitro techniques, we demonstrate heterogeneous expression of CD97, a leukocyte adhesion marker, in human GBM. Beyond its
Externí odkaz:
https://doaj.org/article/401b7d931a4840b5b87625463dbdb581
Study on the anti-hyperuricemic bioactivity and chemical components of Sterculiae lychnophorae Semen
Autor:
Shen-Ming Lv, Meng-Qi Zhang, Jia-Shu Chen, Jian-Shu Liu, Mu-Xuan Wang, Jin-Yue Sun, Chao Liu, Ying-Ying Chen, Xu Guo, Zhi-Xin Liao
Publikováno v:
Journal of Functional Foods, Vol 95, Iss , Pp 105173- (2022)
Sterculiae lychnophorae Semen is an edible and medicinal resource and is widely used in functional foods in China. In the previous study, the S. lychnophorae′ function of anti-hyperuricemia was found, but its main functional ingredients have not be
Externí odkaz:
https://doaj.org/article/480214d9045644ec9acf19e9e39b066b
Autor:
Mu-Xuan Wang, Hong-Wei Qin, Chao Liu, Shen-Ming Lv, Jia-Shu Chen, Chun-Gu Wang, Ying-Ying Chen, Jia-Wei Wang, Jin-Yue Sun, Zhi-Xin Liao
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268531 (2022)
Xanthine oxidase (XO) is a key enzyme in the generation and development of hyperuricemia. Thiazolidine-2-thione, a typical heterocyclic compound, have been widely used in the field of drug synthesis. In this study, a series of novel thiazolidine-2-th
Externí odkaz:
https://doaj.org/article/3e76bb62d94f4d75b5f971337dfbc801
Autor:
Daniele C. Wolf, Sébastien Desgent, Nathalie T. Sanon, Jia-Shu Chen, Lior M. Elkaim, Ciprian M. Bosoi, Patricia N. Awad, Alexe Simard, Muhammad T. Salam, Guillaume-Alexandre Bilodeau, Sandra Duss, Mohamad Sawan, Evan C. Lewis, Alexander G. Weil
Publikováno v:
Neurobiology of Disease, Vol 161, Iss , Pp 105546- (2021)
Febrile seizures (FS) are common, affecting 2–5% of children between the ages of 3 months and 6 years. Complex FS occur in 10% of patients with FS and are strongly associated with mesial temporal lobe epilepsy. Current research suggests that predis
Externí odkaz:
https://doaj.org/article/8731fe1d9396495487d22402c263a09b
Autor:
Elaina J. Wang, Jia-Shu Chen, Saket Jain, Ramin A. Morshed, Alexander F. Haddad, Sabraj Gill, Angad S. Beniwal, Manish K. Aghi
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Glioblastoma is the most common malignant primary brain tumor in adults. Despite treatment consisting of surgical resection followed by radiotherapy and adjuvant chemotherapy, survival remains poor at a rate of 26.5% at 2 years. Recent successes in u
Externí odkaz:
https://doaj.org/article/ff26301da4b74ab894d3b15f61319ec4
Autor:
John P Zepecki, David Karambizi, J Eduardo Fajardo, Kristin M Snyder, Charlotte Guetta-Terrier, Oliver Y Tang, Jia-Shu Chen, Atom Sarkar, Andras Fiser, Steven A Toms, Nikos Tapinos
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009086 (2021)
Within the glioblastoma cellular niche, glioma stem cells (GSCs) can give rise to differentiated glioma cells (DGCs) and, when necessary, DGCs can reciprocally give rise to GSCs to maintain the cellular equilibrium necessary for optimal tumor growth.
Externí odkaz:
https://doaj.org/article/0007be1e0d444154b35e4996ec091839