Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jia-Jie Shi"'
Autor:
Wei-Bang, Yu, Yu-Chi, Chen, Can-Yu, Huang, Zi-Han, Ye, Wei, Shi, Hong, Zhu, Jia-Jie, Shi, Jun, Chen, Jin-Jian, Lu
Publikováno v:
Frontiers of Medicine. 17:105-118
The third-generation epidermal growth factor receptor (EGFR) inhibitor osimertinib (OSI) has been approved as the first-line treatment for EGFR-mutant non-small cell lung cancer (NSCLC). This study aims to explore a rational combination strategy for
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 148:1-14
CD47, a transmembrane protein, acts as a "do not eat me" signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling the tumor cells to escape from macr
Publikováno v:
Mathematical Problems in Engineering, Vol 2020 (2020)
Exploring the submarine landslide is challenging due to the invisibility nature and the complex soil-water interaction and large deformation throughout its runout process. The purpose of this paper is to investigate the ability of the coupled materia
Autor:
Yitao Wang, Mingqing Huang, Jia-Jie Shi, Xiuping Chen, Xin-Ling He, Jin-Jian Lu, Xiao-Huang Xu
Publikováno v:
Current molecular pharmacology. 15(1)
Background: As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe
Publikováno v:
Drug discovery today. 26(2)
Immunotherapy has become an indispensable part of cancer treatment. A pivotal phagocytosis checkpoint, named cluster of differentiation 47 (CD47), which functions as 'don't eat me' signal to protect cells from phagocytosis upon interaction with signa
Publikováno v:
Food chemistry. 327
Platycodonis Radix, the root of Platycodon grandiflorum (Jacq.) A. DC., is a well-known edible herbal medicine. It is a common vegetable used for the preparation of side dish, kimchi, dessert, and tea. Besides, it has been used to treat respiratory d
Publikováno v:
Engineering Geology. 291:106235
Nanjing sand, a type of greenish-grey schistous sand, is rich in weathered mica fragments, making it anisotropic and significantly differ from the round-grained quartz sand in terms of composition, grading, and mechanical properties. In this paper, t
Autor:
Qimin Zhan, Jia-jie Shi, Linghua Meng, Yu-xiang Wang, Meiyu Geng, Xi Zhang, Hui Xing, Jian Ding
Publikováno v:
Cancer letters. 459
Radiotherapy is one of the standard therapies for esophageal squamous cell carcinoma (ESCC), but the efficacy is far from desirable. Large scale genome sequencing reveals PI3Kα is frequently hyper-activated in ESCC. We found that ESCC cells harborin
Autor:
Hong Zhu, Zheng-Hai Tang, Xiao-Ming Jiang, Tao Yuan, Yu-Lian Xu, Ting Li, Xia Guo, Xiao-Huang Xu, Le-Le Zhang, Jia-Jie Shi, Xiuping Chen, Jin-Jian Lu
Publikováno v:
Biochemical Pharmacology. 175:113921
The mammalian target of rapamycin (mTOR) pathway converges diverse environmental cues to support the lung cancer growth and survival. However, the mTOR-targeted mono-therapy does not achieve expected therapeutic effect. Here, we revealed that fangchi
Publikováno v:
Current drug targets. 20(6)
Hypoxia, which occurs in most cancer cases, disrupts the efficacy of anticarcinogens. Fortunately, hypoxia itself is a potential target for cancer treatment. Hypoxia-activated prodrugs (HAPs) can be selectively activated by reductase under hypoxia. S