Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Jia-Heng Tan"'
Autor:
Bo-Zheng Wang, Ying-Chen Zhou, Yu-Wei Lin, Xiu-Cai Chen, Ze-Yi Yu, Yao-Hao Xu, Jia-Heng Tan, Zhi-Shu Huang, Shuo-Bin Chen
Publikováno v:
Molecules, Vol 28, Iss 6, p 2690 (2023)
Mitochondria have a crucial role in regulating energy metabolism and their dysfunction has been linked to tumorigenesis. Cancer diagnosis and intervention have a great interest in the development of new agents that target biomolecules within mitochon
Externí odkaz:
https://doaj.org/article/8878e8f93cc4401a8ba71e24843c8a4c
Autor:
Lan Fang, Wen Shao, Shu-Tang Zeng, Gui-Xue Tang, Jia-Tong Yan, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan, Xiu-Cai Chen
Publikováno v:
Molecules, Vol 27, Iss 20, p 6927 (2022)
RNA imaging is of great importance for understanding its complex spatiotemporal dynamics and cellular functions. Considerable effort has been devoted to the development of small-molecule fluorescent probes for RNA imaging. However, most of the report
Externí odkaz:
https://doaj.org/article/e26679f51e3b4d41955d0d202606a7eb
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 439-447 (2016)
Environments surrounding G-rich sequences remarkably affect the conformations of these structures. A proper evaluation system mimicking the crowded environment in a cell with macromolecules should be developed to perform structural and functional stu
Externí odkaz:
https://doaj.org/article/91ce7703a2b149d5b3558cb87662fd4d
Autor:
Yun-Xia Xiong, Ai-Chun Chen, Pei-Fen Yao, De-Ying Zeng, Yu-Jing Lu, Jia-Heng Tan, Zhi-Shu Huang, Tian-Miao Ou
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 346-352 (2016)
At present, wt1, a Wilms’ tumor suppressor gene, is recognized as a critical regulator of tumorigenesis and a potential therapeutic target. WT1 shows the ability to regulate the transcription of bcl-2 by binding to a GC-rich region in the promoter,
Externí odkaz:
https://doaj.org/article/2d3ff17de6274d4c82612f3924c1a30b
Publikováno v:
Molecules, Vol 23, Iss 2, p 493 (2018)
G-quadruplexes are four-stranded nucleic acid secondary structures that are formed in guanine-rich sequences. G-quadruplexes are widely distributed in functional regions of the human genome and transcriptome, such as human telomeres, oncogene promote
Externí odkaz:
https://doaj.org/article/a0c7aff3139241c2ba571a6fd7228613
Autor:
Tian-Ying Wu, Xiu-Cai Chen, Gui-Xue Tang, Wen Shao, Zhang-Chi Li, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan
Publikováno v:
Journal of Medicinal Chemistry. 66:5484-5499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d411f47f7af64708a0be1f4143aa08
https://doi.org/10.1021/acs.jmedchem.2c01808
https://doi.org/10.1021/acs.jmedchem.2c01808
Autor:
Xiu-Cai Chen, Gui-Xue Tang, Jing Dai, Le-Tian Dai, Tian-Ying Wu, Wen-Wei Li, Tian-Miao Ou, Zhi-Shu Huang, Jia-Heng Tan, Shuo-Bin Chen
Publikováno v:
Journal of Medicinal Chemistry. 66:5171-5184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530a8caaf44c79f76a83392afcd96a89
https://doi.org/10.1021/acs.jmedchem.3c00094
https://doi.org/10.1021/acs.jmedchem.3c00094
Autor:
Jia-En Wang, Ying-Chen Zhou, Bi-Han Wu, Xiu-Cai Chen, Junqiu Zhai, Jia-Heng Tan, Zhi-Shu Huang, Shuo-Bin Chen
Publikováno v:
The Analyst. 148:2343-2351
Here we have developed an immunosorbent assay to accurately and sensitively monitor helicase unwinding a broad range of DNA substrate structures. This assay can be utilized to investigate diverse helicases' functions and to identify their inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c983f93e78af82854c854e77d9df6b44
https://doi.org/10.1039/d2an01989b
https://doi.org/10.1039/d2an01989b
Autor:
Shu-Tang Zeng, Wen Shao, Ze-Yi Yu, Lan Fang, Gui-Xue Tang, Yu-Ying Fang, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan, Xiu-Cai Chen
Publikováno v:
ACS Sensors. 8:40-50
Inter-organelle interactions play a vital role in diverse biological processes. Thus, chemical tools are highly desirable for understanding the spatiotemporal dynamic interplay among organelles in live cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e00f2ccae51657f766f63e01848fa9
https://doi.org/10.1021/acssensors.2c01361
https://doi.org/10.1021/acssensors.2c01361
Autor:
Mao-Lin Li, Jing-Mei Yuan, Hao Yuan, Bi-Han Wu, Shi-Liang Huang, Qing-Jiang Li, Tian-Miao Ou, Hong-Gen Wang, Jia-Heng Tan, Ding Li, Shuo-Bin Chen, Zhi-Shu Huang
Publikováno v:
Journal of Medicinal Chemistry. 65:12675-12700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5266df396b14895123914afea378ad4
https://doi.org/10.1021/acs.jmedchem.2c00467
https://doi.org/10.1021/acs.jmedchem.2c00467