Zobrazeno 1 - 10
of 3 441
pro vyhledávání: '"Jia You"'
Autor:
Liping Zheng, Cheng Zhou, Chengjie Mao, Chao Xie, Jia You, Wei Cheng, Chunfeng Liu, Peiyu Huang, Xiaoujun Guan, Tao Guo, Jingjing Wu, Yajun Luo, Xiaojun Xu, Baorong Zhang, Minming Zhang, Linbo Wang, Jianfeng Feng
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Parkinson’s disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely due to diverse neuroanatomical alterations. This study employs a contrastive deep learning approach to analyze Magnetic Resonance Imaging (MRI) data
Externí odkaz:
https://doaj.org/article/aefe1df2f58049d59221eafecfcdc2ce
Autor:
Jujiao Kang, Yue-Ting Deng, Bang-Sheng Wu, Wei-Shi Liu, Ze-Yu Li, Shitong Xiang, Liu Yang, Jia You, Xiaohong Gong, Tianye Jia, Jin-Tai Yu, Wei Cheng, Jianfeng Feng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Alcohol consumption is a heritable behavior seriously endangers human health. However, genetic studies on alcohol consumption primarily focuses on common variants, while insights from rare coding variants are lacking. Here we leverage whole
Externí odkaz:
https://doaj.org/article/3832146c44b04cd79a8c03aea949af79
Autor:
De-Chao Feng, Wei-Zhen Zhu, Jie Wang, Deng-Xiong Li, Xu Shi, Qiao Xiong, Jia You, Ping Han, Shi Qiu, Qiang Wei, Lu Yang
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-20 (2024)
Abstract In recent years, advancements in single-cell and spatial transcriptomics, which are highly regarded developments in the current era, particularly the emerging integration of single-cell and spatiotemporal transcriptomics, have enabled a deta
Externí odkaz:
https://doaj.org/article/49e6f6fd189c4cbf9044b9003351b3af
Publikováno v:
Journal of the National Cancer Center, Vol 4, Iss 1, Pp 25-35 (2024)
Hepatic stellate cells (HSCs), a distinct category of non-parenchymal cells in the liver, are critical for liver homeostasis. In healthy livers, HSCs remain non-proliferative and quiescent. However, under conditions of acute or chronic liver damage,
Externí odkaz:
https://doaj.org/article/e8a48dd8b27d4d9c8e20070b7a8df46f
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background MicroRNA (miRNA)-based therapies have shown great potential in myocardial repair following myocardial infarction (MI). MicroRNA-302 (miR302) has been reported to exert a protective effect on MI. However, miRNAs are easily degraded
Externí odkaz:
https://doaj.org/article/00bf474ea8dd434ab13586271e28d051
Autor:
Yi-Xuan Qiang, Jia You, Xiao-Yu He, Yu Guo, Yue-Ting Deng, Pei-Yang Gao, Xin-Rui Wu, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Blood-based biomarkers for dementia are gaining attention due to their non-invasive nature and feasibility in regular healthcare settings. Here, we explored the associations between 249 metabolites with all-cause dementia (ACD), A
Externí odkaz:
https://doaj.org/article/96b1ad83ac0f45d99f88c5658a133a61
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101182- (2024)
Externí odkaz:
https://doaj.org/article/730a55e062d04a3f940629c3d3373427
Autor:
Cheng Zhou, Jia You, Xiaojun Guan, Tao Guo, Jingjing Wu, Haoting Wu, Chenqing Wu, Jingwen Chen, Jiaqi Wen, Sijia Tan, Xiaojie Duanmu, Jianmei Qin, Peiyu Huang, Baorong Zhang, Wei Cheng, Jianfeng Feng, Xiaojun Xu, Linbo Wang, Minming Zhang
Publikováno v:
Neurobiology of Disease, Vol 194, Iss , Pp 106472- (2024)
Background: Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms and pathophysiological changes remains controversial. Objectives: We aimed to quantify microstructural changes in hypothalam
Externí odkaz:
https://doaj.org/article/39aa13e782d3429c8bb368f6374dba4b
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27769- (2024)
Objective: This review aims to conduct a comprehensive study of the diagnostic accuracy of interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses. Methods: We performed a thorough search of Embase, Web o
Externí odkaz:
https://doaj.org/article/11833218d5a64ecba262451907e36ee3
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Developing a single-domain assay to identify individuals at high risk of future events is a priority for multi-disease and mortality prevention. By training a neural network, we developed a disease/mortality-specific proteomic risk score (Pr
Externí odkaz:
https://doaj.org/article/2ac12b2207334761b365d93cd61c20af