Quantification of clesrovimab, an investigational, half-life extended, anti-respiratory syncytial virus protein F human monoclonal antibody in the nasal epithelial lining fluid of healthy adults

Autor: Jia Yao Phuah, Brian M. Maas, Aimin Tang, Ying Zhang, Luzelena Caro, Radha A. Railkar, Michael D. Swanson, Yu Cao, Hankun Li, Brad Roadcap, Andrew P. Catchpole, Antonios O. Aliprantis, Kalpit A. Vora

Publikováno v: Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115851- (2023)

Background: Clesrovimab (MK-1654) is an investigational, half-life extended human monoclonal antibody (mAb) against RSV F glycoprotein in clinical trials as a prophylactic agent against RSV infection for infants. Methods: This adult study measured cl

Externí odkaz: https://doaj.org/article/6074672de6f4415ab83703ee8e9116c9

Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype

Autor: Clare M. Smith, Megan K. Proulx, Andrew J. Olive, Dominick Laddy, Bibhuti B. Mishra, Caitlin Moss, Nuria Martinez Gutierrez, Michelle M. Bellerose, Palmira Barreira-Silva, Jia Yao Phuah, Richard E. Baker, Samuel M. Behar, Hardy Kornfeld, Thomas G. Evans, Gillian Beamer, Christopher M. Sassetti

Publikováno v: mBio, Vol 7, Iss 5 (2016)

ABSTRACT The outcome of Mycobacterium tuberculosis infection and the immunological response to the bacillus Calmette-Guerin (BCG) vaccine are highly variable in humans. Deciphering the relative importance of host genetics, environment, and vaccine pr

Externí odkaz: https://doaj.org/article/f64389b5049e4b54bef00318049e02af

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

Autor: Hannah P. Gideon, Travis K. Hughes, Constantine N. Tzouanas, Marc H. Wadsworth, Ang Andy Tu, Todd M. Gierahn, Joshua M. Peters, Forrest F. Hopkins, Jun-Rong Wei, Conner Kummerlowe, Nicole L. Grant, Kievershen Nargan, Jia Yao Phuah, H. Jacob Borish, Pauline Maiello, Alexander G. White, Caylin G. Winchell, Sarah K. Nyquist, Sharie Keanne C. Ganchua, Amy Myers, Kush V. Patel, Cassaundra L. Ameel, Catherine T. Cochran, Samira Ibrahim, Jaime A. Tomko, Lonnie James Frye, Jacob M. Rosenberg, Angela Shih, Michael Chao, Edwin Klein, Charles A. Scanga, Jose Ordovas-Montanes, Bonnie Berger, Joshua T. Mattila, Rajhmun Madansein, J. Christopher Love, Philana Ling Lin, Alasdair Leslie, Samuel M. Behar, Bryan Bryson, JoAnne L. Flynn, Sarah M. Fortune, Alex K. Shalek

Publikováno v: Immunity. 55:827-846.e10

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4751cc76c4a7d51734d0705b3934fa
https://doi.org/10.1016/j.immuni.2022.04.004

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

Autor: Cassaundra Ameel, Alexander G. White, Matthew D. Zimmerman, Jia Yao Phuah, Edwin Klein, Caylin G. Winchell, Mohd Saqib, Brianne Stein, Véronique Dartois, Christopher M. Sassetti, Pauline Maiello, Chelsea M Causgrove, Bibhuti B. Mishra, JoAnne L. Flynn, H. Jacob Borish, Samantha J. Nelson, Philana Ling Lin

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23e2259e484ed0833511f0d768e0a30
http://europepmc.org/articles/PMC7235418

Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype

Autor: Palmira Barreira-Silva, Caitlin E Moss, Samuel M. Behar, Jia Yao Phuah, Richard Baker, Bibhuti B. Mishra, Gillian Beamer, Megan K. Proulx, Clare M. Smith, Michelle M. Bellerose, Christopher M. Sassetti, Andrew J. Olive, Thomas G. Evans, Nuria Martinez Gutierrez, Hardy Kornfeld, Dominick Laddy

Publikováno v: mBio, Vol 7, Iss 5, p e01516-16 (2016)
mBio
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
mBio, Vol 7, Iss 5 (2016)

The outcome of Mycobacterium tuberculosis infection and the immunological response to the bacillus Calmette-Guerin (BCG) vaccine are highly variable in humans. Deciphering the relative importance of host genetics, environment, and vaccine preparation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266e14c911995d6c8a837ba6f13faaa7
http://mbio.asm.org/cgi/content/full/7/5/e01516-16