Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jia Wei Siau"'
Autor:
Jia Wei Siau, Asim Azhar Siddiqui, Sze Yi Lau, Srinivasaraghavan Kannan, Sabrina Peter, Yingying Zeng, Chandra Verma, Peter Droge, John F. Ghadessy
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a8102e41f4cd4c198dc89e84d4769ffd
Autor:
Farid J. Ghadessy, Roman A. Zubarev, Anna Rising, Lennart Nilsson, Gefei Chen, Philip J.B. Koeck, Nicolas Fritz, Thibault Vosselman, David P. Lane, Michael Landreh, Leopold L. Ilag, Pierre Sabatier, Aik Seng Ng, Jan Johansson, Saikiran K. Sedimbi, Venla A. Väänänen, Jia Wei Siau, Xueying Zhong, Médoune Sarr, Margit Kaldmäe, Borivoj Vojtesek, Nina Kronqvist, Mihkel Saluri, Dilraj Lama, Nicklas Österlund, Cagla Sahin
Protein disorder is a major hurdle for structural biology. A prominent example is the tumour suppressor p53, whose low expression levels and poor conformational stability due to a high degree of disorder pose major challenges to the development of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec1032525eb1410efe687fc4f9fe084d
https://doi.org/10.1101/2021.02.22.432221
https://doi.org/10.1101/2021.02.22.432221
Autor:
Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Mihkel Saluri, Nina Kronqvist, Jia Wei Siau, Aik Seng Ng, Farid J. Ghadessy, Pierre Sabatier, Borivoj Vojtesek, Médoune Sarr, Cagla Sahin, Nicklas Österlund, Leopold L. Ilag, Venla A. Väänänen, Saikiran Sedimbi, Marie Arsenian-Henriksson, Roman A. Zubarev, Lennart Nilsson, Philip J.B. Koeck, Anna Rising, Axel Abelein, Nicolas Fritz, Jan Johansson, David P. Lane, Michael Landreh
Publikováno v:
Structure. 30:733-742.e7
Disordered proteins pose a major challenge to structural biology. A prominent example is the tumor suppressor p53, whose low expression levels and poor conformational stability hamper the development of cancer therapeutics. All these characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed31ce0f39f565556e02e0e4ce74b7b5
https://doi.org/10.1016/j.str.2022.02.013
https://doi.org/10.1016/j.str.2022.02.013
Autor:
Jia Wei Siau, Lau Sy, Radoslaw M. Sobota, David P. Lane, Cheng-I Wang, Farid J. Ghadessy, Zhong P
Publikováno v:
Protein Engineering, Design and Selection
Engineered non-antibody scaffold proteins constitute a rapidly growing technology for diagnostics and modulation/perturbation of protein function. Here, we describe the rapid and systematic development of high-affinity 10FN3 domain inhibitors of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362dbf6490451395d2f9d25607fc29f4
https://doi.org/10.1093/protein/gzy018
https://doi.org/10.1093/protein/gzy018
Autor:
Srinivasaraghavan Kannan, Zahra Ouaray, David P. Lane, Matthew Nguyen, Farid J. Ghadessy, Chandra S. Verma, Chee Keong Kwoh, Jia Wei Siau, Mohan R. Pradhan
Publikováno v:
Nucleic Acids Research
The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dafc927c7a6f94465c871e041e29521
https://hdl.handle.net/10356/105824
https://hdl.handle.net/10356/105824
Autor:
Samuel Nonis, Fernando J. Ferrer, Sharon Chee, Jia Wei Siau, Christopher J. Brown, Li Quan Koh, Farid J. Ghadessy
Publikováno v:
Nucleic Acids Research
Directed evolution methodologies benefit from read-outs quantitatively linking genotype to phenotype. We therefore devised a method that couples protein–peptide interactions to the dynamic read-out provided by an engineered DNA polymerase. Fusion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8a39df365501caf44b6445dc748880
http://europepmc.org/articles/PMC7736784
http://europepmc.org/articles/PMC7736784
Autor:
Sharon Chee, Shree Harsha Vijaya Chandra, Farid J. Ghadessy, Harshyaa Makhija, Peter Dröge, Cho Mar Myint Wai, Jia Wei Siau, Sabrina Peter
Publikováno v:
Protein Engineering, Design and Selection. 28:211-220
Advances in genome engineering are attendant on the development of novel enzyme variants with programed substrate specificities and improved activity. We have devised a novel selection method, wherein the activity of a recombinase deletes the gene en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ead20869fa5a5b6a9a6b0b5c5dea2b1
https://doi.org/10.1093/protein/gzv015
https://doi.org/10.1093/protein/gzv015
Autor:
Farid J. Ghadessy, Jia Wei Siau, Juliane Hundt, Weiyun Villien Zhang, Chandra S. Verma, Yaw Sing Tan, David P. Lane, Cynthia R. Coffill
Publikováno v:
Scientific Reports
The identification of genes encoding a p53 family member and an Mdm2 ortholog in the ancient placozoan Trichoplax adhaerens advocates for the evolutionary conservation of a pivotal stress-response pathway observed in all higher eukaryotes. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32080da57ea1aa0f0134398e329f0e0c
Autor:
Cynthia R. Coffill, Boon-Hui Tay, Sharon Chee, David P. Lane, Thomas Leonard Joseph, Jia Wei Siau, Farid J. Ghadessy, Chandra S. Verma, Yaw Sing Tan, Arumugam Madhumalar, Sydney Brenner, Alison P. Lee, Byrappa Venkatesh
The extant jawless vertebrates, represented by lampreys and hagfish, are the oldest group of vertebrates and provide an interesting genomic evolutionary pivot point between invertebrates and jawed vertebrates. Through genome analysis of one of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46834b55a7adf9470e03212c5b056b4f
https://europepmc.org/articles/PMC4743058/
https://europepmc.org/articles/PMC4743058/
Publikováno v:
Micron. 43:996-1000
Transcription factors play a central role in cell biology through binding to target DNA elements and regulating gene expression. In this study, we used the p53 tumour suppressor as a model transcription factor to develop an imaging based assay to mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ebb3c1b90df5e21db37c4321f8ebc7
https://doi.org/10.1016/j.micron.2012.03.024
https://doi.org/10.1016/j.micron.2012.03.024