Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jia Q. Ng"'
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Autor:
Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin R. M. Lannagan, Tongtong Wang, Josephine A. Wright, Hiroki Kobayashi, Jia Q. Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L. Worthley, Susan L. Woods, Tal Danino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Niss
Externí odkaz:
https://doaj.org/article/16a3783ebc994816bc3440bb05df9c6f
Autor:
Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah M. Ali, Yan Ma, Georgette A. Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David J. Hunter, Tamsin R. M. Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David R. Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage. Here we show that the BMP-antagonist Gremlin 1 (Grem1) marks a bipotent chondrogenic and osteogenic progenitor cell population within the articular
Externí odkaz:
https://doaj.org/article/8fef35728baa46f097358d129ef88852
Autor:
Mari Ichinose, Nobumi Suzuki, Tongtong Wang, Josephine A. Wright, Tamsin R. M. Lannagan, Laura Vrbanac, Hiroki Kobayashi, Krystyna Gieniec, Jia Q. Ng, Souzaburo Ihara, Chris Mavrangelos, Yoku Hayakawa, Patrick Hughes, Daniel L. Worthley, Susan L. Woods
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The intestinal stroma provides an important microenvironment for immune cell activation. The perturbation of this tightly regulated process can lead to excessive inflammation. We know that upregulated Toll-like receptor 4 (TLR4) in the intes
Externí odkaz:
https://doaj.org/article/aebf352fe0324c3cb4059278bf6e460e
Autor:
Candice R. Gurbatri, Georgette Radford, Laura Vrbanac, Courtney Coker, Jong-won Im, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin RM Lannagan, Tongtong Wang, Josephine A Wright, Elaine Thomas, Hiroki Kobayashi, Jia Q Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L Worthley, Susan L Woods, Tal Danino
Publikováno v:
bioRxiv
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa60062672f0b39d77dd9740b766a751
https://europepmc.org/articles/PMC10104002/
https://europepmc.org/articles/PMC10104002/
Autor:
Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah Ali, Yan Ma, Georgette A Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David Hunter, Tamsin RM Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee
Publikováno v:
bioRxiv
SUMMARYOsteoarthritis (OA), which carries an enormous disease burden across the world, is characterised by irreversible degeneration of articular cartilage (AC), and subsequently bone. The cellular cause of OA is unknown. Here, using lineage tracing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b09dfb708bd633ea3b8d056b7f495f4
https://europepmc.org/articles/PMC10081168/
https://europepmc.org/articles/PMC10081168/
Autor:
Susan L. Woods, Krystyna A. Gieniec, Eva M. Monsalve, Mari Ichinose, Tamsin R M Lannagan, Hiroki Kobayashi, Yoku Hayakawa, Josephine A. Wright, Jorge Laborda, Laura Vrbanac, Jia Q Ng, Tongtong Wang, Nobumi Suzuki, Patricia García-Gallastegui, Steven R. Bauer, Gaskon Ibarretxe, José J. García-Ramírez, Daniel L. Worthley
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G506-G520
The stem/progenitor cells of the developing intestine are biologically distinct from their adult counterparts. Here, we examine the microenvironmental cues that regulate the embryonic stem/progenitor population, focusing on the role of Notch pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d291651f38121a9933d88eae80fcab
https://doi.org/10.1152/ajpgi.00445.2020
https://doi.org/10.1152/ajpgi.00445.2020
Autor:
Alastair D. Burt, Nobumi Suzuki, Mari Ichinose, Laura Vrbanac, Susan L. Woods, Krystyna A. Gieniec, Georgette Radford, Tamsin R M Lannagan, Jarrad M. Goyne, Masahide Takahashi, Tongtong Wang, Elaine M. Thomas, Hiroki Kobayashi, Atsushi Enomoto, Daniel L. Worthley, Josephine A. Wright, Jia Q Ng
Publikováno v:
Journal of Visualized Experiments.
Hepatic metastasis of colorectal cancer (CRC) is a leading cause of cancer-related death. Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment, play a crucial role in metastatic CRC progression and predict poor patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9a42556304468029dfc61938e3bc42
https://doi.org/10.3791/62630
https://doi.org/10.3791/62630
Autor:
Martin Lewis, Simon A. Koblar, Paul Q. Thomas, Susan L. Woods, Atsushi Enomoto, Ryota Ando, Nobumi Suzuki, Tongtong Wang, Krystyna A. Gieniec, Josephine A. Wright, Tamsin R M Lannagan, Laura Vrbanac, Jia Q Ng, Daniel L. Worthley, Hiroki Kobayashi, Mari Ichinose
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Bone morphogenetic protein (BMP) signaling is required for early forebrain development and cortical formation. How the endogenous modulators of BMP signaling regulate the structural and functional maturation of the developing brain remains unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce58a7e32b47dd420adcbb63c87e134
https://doi.org/10.1242/dev.195883
https://doi.org/10.1242/dev.195883
Autor:
Hiroki Kobayashi, Krystyna A. Gieniec, Tamsin R.M. Lannagan, Tongtong Wang, Naoya Asai, Yasuyuki Mizutani, Tadashi Iida, Ryota Ando, Elaine M. Thomas, Akihiro Sakai, Nobumi Suzuki, Mari Ichinose, Josephine A. Wright, Laura Vrbanac, Jia Q. Ng, Jarrad Goyne, Georgette Radford, Matthew J. Lawrence, Tarik Sammour, Yoku Hayakawa, Sonja Klebe, Alice E. Shin, Samuel Asfaha, Mark L. Bettington, Florian Rieder, Nicholas Arpaia, Tal Danino, Lisa M. Butler, Alastair D. Burt, Simon J. Leedham, Anil K. Rustgi, Siddhartha Mukherjee, Masahide Takahashi, Timothy C. Wang, Atsushi Enomoto, Susan L. Woods, Daniel L. Worthley
Publikováno v:
Paediatrics Publications
Gastroenterology
Gastroenterology
Background & Aims: Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ab04f43fe5a9cdebfa428f4a1362b7
https://pubmed.ncbi.nlm.nih.gov/34983959
https://pubmed.ncbi.nlm.nih.gov/34983959
Autor:
Souzaburo Ihara, Yoku Hayakawa, Krystyna A. Gieniec, Tamsin R M Lannagan, Tongtong Wang, Patrick A. Hughes, Josephine A. Wright, Nobumi Suzuki, Susan L. Woods, Jia Q Ng, Daniel L. Worthley, Chris Mavrangelos, Hiroki Kobayashi, Laura Vrbanac, Mari Ichinose
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The intestinal stroma provides an important microenvironment for immune cell activation. The perturbation of this tightly regulated process can lead to excessive inflammation. We know that upregulated Toll-like receptor 4 (TLR4) in the intestinal epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc89aa14612a14cab4cafd2af48b4cee
http://europepmc.org/articles/PMC8010037
http://europepmc.org/articles/PMC8010037