Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression

Autor: Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Spermidine, a polyamine reported to extend lifespan and reduce the risk of age-related diseases, serves as a substrate for the post-translational modification hypusination. Here the authors report that EIF5A hypusination, which regulates mitochondria

Externí odkaz: https://doaj.org/article/27de688eb5a24929b14771a4cd8acfce

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis

Autor: Jin Zhou, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Macalinao Dominique Camat, Anne James, Yajun Wu, Jianhong Ching, Jean-Paul Kovalik, Kiat-Hon Lim, Stuart Alexander Cook, Boon-Huat Bay, Brijesh Kumar Singh, Paul Michael Yen

Publikováno v: Thyroid : official journal of the American Thyroid Association. 32(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389df3986cf104d27fbb5c65dd9e27bd
https://pubmed.ncbi.nlm.nih.gov/35317606

IDDF2021-ABS-0150 Influence of ethnicity on the gut microbiota of singaporean and malaysian communities

Autor: Jeremy Fung Yen Lim, Tin Tin Su, Jonathan Wei Jie Lee, Chun Wie Chong, Jia Pei Ho, Kai Yee Toh, Jacky Dwiyanto, Sadequr Rahman

Publikováno v: Basic Gastronenterology.

Background Singapore and Malaysia are neighbouring countries with similar ethnic make-up: Chinese, Indian, and Malays. However, Singapore is a high-income economy while Malaysia is a middle-income economy. Such a difference has resulted in some level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b834e87b87fa1144f04e9644be7703b
https://doi.org/10.1136/gutjnl-2021-iddf.46

Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle

Autor: Xuguang Zhu, Rohit A. Sinha, Jia Pei Ho, Paul M. Yen, Cho Rong Han, Karine Gauthier, Sheue-yann Cheng, Andrea Lim, Jin Zhou

Publikováno v: Endocrinology
Endocrinology, 2021, 162 (9), ⟨10.1210/endocr/bqab112⟩
Endocrinology, Endocrine Society, 2021, 162 (9), ⟨10.1210/endocr/bqab112⟩

Skeletal muscle (SM) weakness occurs in hypothyroidism and resistance to thyroid hormone α (RTHα) syndrome. However, the cell signaling and molecular mechanism(s) underlying muscle weakness under these conditions is not well understood. We thus exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e473ccb3ae8d0e9b9d86e615b07c0215
https://hal.science/hal-03403597

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Autor: Madhulika Tripathi, Paul M. Yen, Donald P. McDonnell, Boon-Huat Bay, Anthony N. Hollenberg, Brijesh K. Singh, Rohit A. Sinha, Sherwin Xie, Karine Gauthier, Sujoy Ghosh, Jia Pei Ho, Jin Zhou, Jann A. C. Sy, Vincent Giguère, Yajun Wu, Jean-Marc Vanacker, Kenji Ohba, Ching-Yi Chang, Arturo Mendoza

Publikováno v: Science Signaling. 11

Thyroid hormone receptor β1 (THRB1) and estrogen-related receptor α (ESRRA; also known as ERRα) both play important roles in mitochondrial activity. To understand their potential interactions, we performed transcriptome and ChIP-seq analyses and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8346fc3a0451d7627b5826bd2a81ac
https://doi.org/10.1126/scisignal.aam5855