Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

Autor: Karol Estrada, Thomas Meitinger, Christopher J. Groves, Tim D. Spector, Paul W. Franks, Weihua Zhang, Nicholas J. Timpson, Leena Peltonen, M. Carola Zillikens, Alexander W. Drong, Leonie C. Jacobs, Massimo Mangino, Nita G. Forouhi, Fredrik Karpe, Inga Prokopenko, Amanda J. Bennett, G. Mark Lathrop, Cornelia M. van Duijn, Albert Hofman, Michael Boehnke, Inês Barroso, Veikko Salomaa, Lu Qi, John F. Peden, Fernando Rivadeneira, Mark I. McCarthy, Jaakko Tuomilehto, Joel N. Hirschhorn, Nilesh J. Samani, Frank B. Hu, Edward G. Lakatta, Alex S. F. Doney, Najaf Amin, Anders Hamsten, Hugh Watkins, Johanna Kuusisto, Elizabeth K. Speliotes, Narisu Narisu, Guido Fischer, Wendy L. McArdle, David Hadley, Manjinder S. Sandhu, Francis S. Collins, Paul Elliott, Vincent Mooser, Luigi Ferrucci, Leif Groop, H.-Erich Wichmann, Serena Sanna, Xin Yuan, Anna F. Dominiczak, Peter S. Chines, Lachlan J. M. Coin, Lynn Cherkas, Cyrus Cooper, Mario A. Morken, Colin N. A. Palmer, Frida Renström, Blanca M. Herrera, Kijoung Song, Markku Laakso, Marjo-Riitta Järvelin, Kaisa Silander, David Schlessinger, Kari Stefansson, Peter Nordström, David P. Strachan, Angelo Scuteri, Michael N. Weedon, Jia N.an Luan, Rolf Holle, Joshua C. Randall, Yurii S. Aulchenko, Aimo Ruokonen, Stefania Bandinelli, Andrew D. Morris, Shah Ebrahim, Noha Lim, Nicholas J. Wareham, Tiinamaija Tuomi, Mark J. Caulfield, Paul Scheet, Karen L. Mohlke, Gudmar Thorleifsson, Debbie A Lawlor, Karen A. Jameson, Peter Almgren, Lori L. Bonnycastle, Candace Guiducci, Timothy M. Frayling, David J. Hunter, Amy J. Swift, Peter Vollenweider, Iris M. Heid, Stephen J. Chanock, Felicity Payne, Ruth J. F. Loos, George Davey Smith, Gonçalo R. Abecasis, Jaana Laitinen, Andrew T. Hattersley, Cristen J. Willer, Suzannah Bumpstead, G. Bragi Walters, Pekka Jousilahti, Harald Grallert, Laura J. Scott, Panos Deloukas, Cuilin Zhang, Ben A. Oostra, Thomas Illig, Claudia Lamina, Dawn M. Waterworth, Angela Doering, Patricia B. Munroe, Toshiko Tanaka, Chris Wallace, Unnur Thorsteinsdottir, Gabriel Crawford, John C. Chambers, John W. Holloway, Christian Gieger, Gérard Waeber, Jacqueline C.M. Witteman, Ian N. M. Day, Michael R. Erdos, Augustine Kong, Bo Isomaa, Anne U. Jackson, Scott M. Grundy, Andrew P. Morris, Hua Zhao Jing, Aki S. Havulinna, André G. Uitterlinden, Valgerdur Steinthorsdottir, Cecilia M. Lindgren, Richard N. Bergman, Anna Nordström, Manuela Uda, Jaspal S. Kooner, Nicole Soranzo, Heather M. Stringham, Helen N. Lyon

Publikováno v: PLoS genetics
PLoS Genet. 5:e1000508 (2009)
PLoS Genetics, vol. 5, no. 6, pp. e1000508
PLoS
PLoS Genetics
PLoS Genetics; Vol 5
Lindgren, C M, Heid, I M, Randall, J C, Lamina, C, Steinthorsdottir, V, Qi, L, Speliotes, E K, Thorleifsson, G, Willer, C J, Herrera, B M, Jackson, A U, Lim, N, Scheet, P, Soranzo, N, Amin, N, Aulchenko, Y S, Chambers, J C, Drong, A, Luan, J, Lyon, H N, Rivadeneira, F, Sanna, S, Timpson, N J, Zillikens, M C, Jing, H Z, Almgren, P, Bandinelli, S, Bennett, A J, Bergman, R N, Bonnycastle, L L, Bumpstead, S J, Chanock, S J, Cherkas, L, Chines, P, Coin, L, Cooper, C, Crawford, G, Doering, A, Dominiczak, A, Doney, A S F, Ebrahim, S, Elliott, P, Erdos, M R, Estrada, K, Ferrucci, L, Fischer, G, Forouhi, N G, Gieger, C, Grallert, H, Groves, C J, Grundy, S, Guiducci, C, Hadley, D, Hamsten, A, Havulinna, A S, Hofman, A, Holle, R, Holloway, J W, Illig, T, Isomaa, B, Jacobs, L C, Jameson, K, Jousilahti, P, Karpe, F, Kuusisto, J, Laitinen, J, Lathrop, G M, Lawlor, D A, Mangino, M, McArdle, W L, Meitinger, T, Morken, M A, Morris, A P, Munroe, P, Narisu, N, Nordström, A, Nordström, P, Oostra, B A, Palmer, C N A, Payne, F, Peden, J F, Prokopenko, I, Renström, F, Ruokonen, A, Salomaa, V, Sandhu, M S, Scott, L J, Scuteri, A, Silander, K, Song, K, Yuan, X, Stringham, H M, Swift, A J, Tuomi, T, Uda, M, Vollenweider, P, Waeber, G, Wallace, C, Walters, G B, Weedon, M N, Witteman, J C M, Zhang, C, Zhang, W, Caulfield, M J, Collins, F S, Smith, G D, Day, I N M, Franks, P W, Hattersley, A T, Hu, F B, Jarvelin, M R, Kong, A, Kooner, J S, Laakso, M, Lakatta, E, Mooser, V, Morris, A D, Peltonen, L, Samani, N J, Spector, T D, Strachan, D P, Tanaka, T, Tuomilehto, J, Uitterlinden, A G, Van Duijn, C M, Wareham, N J, Watkins, H, Waterworth, D M, Boehnke, M, Deloukas, P, Groop, L, Hunter, D J, Thorsteinsdottir, U, Schlessinger, D, Wichmann, H E, Frayling, T M, Abecasis, G R, Hirschhorn, J N, Loos, R J F, Stefansson, K, Mohlke, K L, Barroso, I & McCarthy, M I 2009, ' Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution ', PLoS Genetics, vol. 5, no. 6, e1000508 . https://doi.org/10.1371/journal.pgen.1000508
PLoS Genetics, Vol 5, Iss 6, p e1000508 (2009)

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 2

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https://openaccess.sgul.ac.uk/id/eprint/1561/1/pgen.1000508.pdf