Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jia Min Loo"'
Autor:
Louis Jun Ye Ong, Shumei Chia, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Jia Min Loo, Wei Yong Chua, Clarinda Chua, Emile Tan, Hannes Hentze, Iain Beehuat Tan, Ramanuj DasGupta, Yi-Chin Toh
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more personalised approach to cancer therapy. Although patient-derived xenograft (PDX) models can generate drug response specific to patients, they are not sustainable in
Externí odkaz:
https://doaj.org/article/85f6517cb8294c69a16c75eda4b57a62
Autor:
Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R. J. Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-ass
Externí odkaz:
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d
Autor:
Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie
Publikováno v:
eLife, Vol 8 (2019)
Colorectal cancer (CRC) is a major cause of human death. Mortality is primarily due to metastatic organ colonization, with the liver being the main organ affected. We modeled metastatic CRC (mCRC) liver colonization using patient-derived primary and
Externí odkaz:
https://doaj.org/article/df6349d3163c42688775653c831ce857
Autor:
Yongliang Zhang, Heng Boon Low, Yik-Lam Cho, Herbert Schwarz, Nicholas R. J. Gascoigne, Fengchun Xiao, Chin Wen Png, Fiona Yi Xin Lee, Xiaohong Xu, Bangyuan Wu, Jia Min Loo, Han-Ming Shen, Li Ren Kong, Henry Yang, Ramanuj DasGupta, Zhen Lim Wong, Xuan Xin, Chun-Wei Li, Boon Cher Goh, Iain Beehuat Tan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast ca
Autor:
Masoud Tavazoie, Marwan Fakih, Isabel Kurth, Shugaku Takeda, Scott L. Spector, Helen S. Tian, Andrea Cercek, Andrew Eugene Hendifar, Jia Min Loo, Norihiro Yamaguchi, Robert Wasserman, Syed Ahsan Raza, Robert Busby, Afsar Barlas, Katia Manova-Todorova, Lee S. Rosen, James Strauss, Sohail F. Tavazoie, Subhasree Sridhar, Johanna C. Bendell, Michael Szarek, Autumn J. McRee, Celia Andreu-Agullo, Foster C. Gonsalves
Publikováno v:
Science advances, vol 7, iss 41
Science Advances
Science Advances
Description
RGX-202, a small-molecule creatine transporter SLC6A8 inhibitor, suppresses colorectal cancer and modulates human creatine levels.
Colorectal cancer (CRC) is a leading cause of cancer mortality. Creatine metabolism was previousl
RGX-202, a small-molecule creatine transporter SLC6A8 inhibitor, suppresses colorectal cancer and modulates human creatine levels.
Colorectal cancer (CRC) is a leading cause of cancer mortality. Creatine metabolism was previousl
Autor:
Ignasius Joanito, Pratyaksha Wirapati, Nancy Zhao, Zahid Nawaz, Grace Yeo, Fiona Lee, Christine L. P. Eng, Dominique Camat Macalinao, Merve Kahraman, Harini Srinivasan, Vairavan Lakshmanan, Sara Verbandt, Petros Tsantoulis, Nicole Gunn, Prasanna Nori Venkatesh, Zhong Wee Poh, Rahul Nahar, Hsueh Ling Janice Oh, Jia Min Loo, Shumei Chia, Lih Feng Cheow, Elsie Cheruba, Michael Thomas Wong, Lindsay Kua, Clarinda Chua, Andy Nguyen, Justin Golovan, Anna Gan, Wan-Jun Lim, Yu Amanda Guo, Choon Kong Yap, Brenda Tay, Yourae Hong, Dawn Qingqing Chong, Aik-Yong Chok, Woong-Yang Park, Shuting Han, Mei Huan Chang, Isaac Seow-En, Cherylin Fu, Ronnie Mathew, Ee-Lin Toh, Lewis Z. Hong, Anders Jacobsen Skanderup, Ramanuj DasGupta, Chin-Ann Johnny Ong, Kiat Hon Lim, Emile K. W. Tan, Si-Lin Koo, Wei Qiang Leow, Sabine Tejpar, Shyam Prabhakar, Iain Beehuat Tan
Publikováno v:
Nature genetics. 54(7)
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing on 49,155
Autor:
Ryan H. Moy, Alexander Nguyen, Jia Min Loo, Norihiro Yamaguchi, Christina M. Kajba, Balaji Santhanam, Benjamin N. Ostendorf, Y. Gloria Wu, Saeed Tavazoie, Sohail F. Tavazoie
Publikováno v:
Dev Cell
Developmental cell, vol 57, iss 9
Developmental cell, vol 57, iss 9
Metastatic colonization is the primary cause of death from colorectal cancer (CRC). We employed genome-scale invivo short hairpin RNA (shRNA) screening and validation to identify 26 promoters of CRC liver colonization. Among these genes, we identifie
Autor:
James Strauss, Robert Busby, Sohail F. Tavazoie, Isabel Kurth, Subhasree Sridhar, Lee S. Rosen, Katia Manova-Todorova, Autumn J. McRee, Andrew Eugene Hendifar, Johanna C. Bendell, Afsar Barlas, Masoud Tavazoie, Jia Min Loo, Norihiro Yamaguchi, Syed Ahsan Raza, Marwan Fakih, Andrea Cercek, Foster C. Gonsalves, Helen S. Tian, Scott L. Spector, Robert Wasserman, Celia Andreu-Agullo, Shugaku Takeda
Colorectal cancer (CRC) is a leading cause of cancer mortality. Creatine metabolism was previously shown to critically regulate colon cancer progression. We report that RGX-202, an oral small-molecule SLC6A8 creatine transporter inhibitor, robustly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2dd18253d3576d4e2b64ed4f4fcca5f
https://doi.org/10.1101/2021.04.26.441371
https://doi.org/10.1101/2021.04.26.441371
Autor:
Ethan M. Weinberg, Norihiro Yamaguchi, Leonard B. Saltz, Alexander Nguyen, Sohail F. Tavazoie, Philip B. Paty, Elisa de Stanchina, Maria V. Liberti, T. Peter Kingham, Yelena Y. Janjigian, Jia Min Loo, Hani Goodarzi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab006f4748aeef0b995f568d89bc5c3b
https://doi.org/10.7554/elife.52135.sa2
https://doi.org/10.7554/elife.52135.sa2
Autor:
Alexander Nguyen, Norihiro Yamaguchi, Leonard B. Saltz, T. Peter Kingham, Hani Goodarzi, Jia Min Loo, Maria V. Liberti, Elisa de Stanchina, Sohail F. Tavazoie, Yelena Y. Janjigian, Philip B. Paty, Ethan M. Weinberg
Colorectal cancer (CRC) is a major cause of human death. Mortality is primarily due to metastatic organ colonization, with liver being the primary organ affected. We modeled metastatic CRC (mCRC) liver colonization using patient-derived primary and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f06e87d343d749ab46990910faf9e73