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of 60
pro vyhledávání: '"Jia Long Fang"'
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 148-154 (2021)
Polyethylene glycol (PEG) is a biocompatible polymer used in biotherapeutics to increase bioavailability, reduce the frequency of administration, and optimize pharmacokinetics. Anti-PEG antibodies have been detected in healthy individuals and may dec
Externí odkaz:
https://doaj.org/article/28bf6583faa44ed4b1fc8da7ae99fd07
Autor:
Zhao-Hua Zhou, Margaret M. Cortese, Jia-Long Fang, Robert Wood, Donna S. Hummell, Kimberly A. Risma, Allison E. Norton, Mark KuKuruga, Susan Kirshner, Ronald L. Rabin, Cyrus Agarabi, Mary A. Staat, Natasha Halasa, Russell E. Ware, Anna Stahl, Maureen McMahon, Peter Browning, Panagiotis Maniatis, Shanna Bolcen, Kathryn M. Edwards, John R. Su, Sai Dharmarajan, Richard Forshee, Karen R. Broder, Steven Anderson, Steven Kozlowski
BackgroundThe mechanism for anaphylaxis following mRNA COVID-19 vaccination has been widely debated; understanding this serious adverse event is important for future vaccines of similar design. A mechanism proposed is type I hypersensitivity (i.e., I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff339813a34daee1822c1fe92408594
https://doi.org/10.1101/2023.04.11.23288372
https://doi.org/10.1101/2023.04.11.23288372
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 148-154 (2021)
Toxicology Reports, Vol 8, Iss, Pp 148-154 (2021)
Graphical abstract
Highlights • A rapid, sensitive, and specific flow cytometry assay was developed to detect anti-PEG IgG and IgM in human blood plasma. • Using the method, anti-PEG IgG or IgM were detected in 65% of plasma samples from 300
Highlights • A rapid, sensitive, and specific flow cytometry assay was developed to detect anti-PEG IgG and IgM in human blood plasma. • Using the method, anti-PEG IgG or IgM were detected in 65% of plasma samples from 300
Autor:
Jia-Long Fang, Michelle M. Vanlandingham, Frederick A. Beland, Robert P. Felton, Mackean P. Maisha, Greg R. Olson, Ralph E. Patton, Amy S. Rosenberg, Gonçalo Gamboa da Costa
Publikováno v:
Toxicol Lett
Polyethylene glycol (PEG) is present in a variety of products. Little is known regarding the accumulation of high-molecular-weight PEGs or the long-term effects resulting from PEG accumulation in certain tissues, especially the choroid plexus. We eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5577d03b5069439a26a0d940e1eb69
https://europepmc.org/articles/PMC8932377/
https://europepmc.org/articles/PMC8932377/
Autor:
Mary K. Schubauer-Berigan, Heidi Mattock, Kathryn Z. Guyton, Wendy C Andersen, Fatiha El Ghissassi, Julia M Gohlke, William M. Gwinn, Daniel R. S. Middleton, Eero Suonio, Pascal Jj Sanders, Frank Le Curieux, Takashi Umemura, Jia-Long Fang, Guosheng Chen, Lamia Benbrahim-Tallaa, Anjoeka Pronk, Yann Grosse, Adalberto Miranda-Filho, Meng Sun, Kamila Mitrowska, Gisela A Umbuzeiro, Felicia Fei-Lei Chung
Publikováno v:
Lancet Oncology
Lancet Oncology, Elsevier, 2021, 22 (5), pp.585-586. ⟨10.1016/S1470-2045(21)00178-9⟩
Lancet Oncology, Elsevier, 2021, 22 (5), pp.585-586. ⟨10.1016/S1470-2045(21)00178-9⟩
International audience; In February–March, 2021, a Working Group of 11 scientists from eight countries met remotely at the invitation of the International Agency for Research on Cancer (IARC) to finalise their evaluation of the carcinogenicity of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cbe8d9795d0ca71604777b40e8424a
https://hal.archives-ouvertes.fr/hal-03443888
https://hal.archives-ouvertes.fr/hal-03443888
Autor:
Yangshun Tang, Yuanfeng Wu, Jia-Long Fang, Greg R. Olson, Michelle Vanlandingham, Frederick A. Beland
Publikováno v:
Archives of Toxicology. 92:3391-3402
Triclosan, a widely used broad spectrum anti-bacterial agent, is hepatotoxic in rodents and exhibits differential effects on mouse and human peroxisome proliferator-activated receptor alpha (PPARα) in vitro; however, the mechanism underlying triclos
Autor:
Priyanka Chitranshi, Lucie Loukotková, Jie Zhang, Gonçalo Gamboa da Costa, Jia-Long Fang, Frederick A. Beland, Yuanfeng Wu
Publikováno v:
Archives of Toxicology. 91:2405-2423
Triclosan is a widely used broad-spectrum anti-bacterial agent. The objectives of this study were to identify which cytochrome P450 (CYP) isoforms metabolize triclosan and to examine the effects of CYP-mediated metabolism on triclosan-induced cytotox
Autor:
Jia-Long Fang, Gonçalo Gamboa da Costa, Si Chen, Yuanfeng Wu, Priyanka Chitranshi, Frederick A. Beland
Publikováno v:
Toxicological Sciences. 150:27-39
Tolvaptan, a vasopressin receptor 2 antagonist used to treat hyponatremia, has recently been reported to be associated with liver injury. Sulfotransferases (SULTs) have been implicated as important detoxifying and/or activating enzymes for numerous x
Publikováno v:
Toxicology in Vitro. 62:104669
Amodiaquine (ADQ), an antimalarial drug used in endemic areas, has been reported to be associated with liver toxicity; however, the mechanism underlying its hepatoxicity remains unclear. In this study, we examined the cytotoxicity of ADQ and its majo
Autor:
Gonçalo Gamboa da Costa, Lucie Loukotková, Priyanka Chitranshi, Frederick A. Beland, Jia-Long Fang
Publikováno v:
Biochemical pharmacology. 155
Nevirapine, a non-nucleoside reverse transcriptase inhibitor used for the treatment of AIDS, can cause serious skin rashes and hepatotoxicity. Previous studies have indicated that the benzylic sulfate 12-sulfoxynevirapine, the formation of which is c