Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jia L. Xu"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 117:123-131
Curcumin (Cur) is a strong natural antioxidant, who can prevent multiple diseases such as anti-cancer, anti-inflammatory, have a resistance to alzheimer's disease and various malignant diseases. But it has poor oral bioavailability due to its poor aq
Autor:
Gene W. Yeo, Jia L. Xu, Sebastian Markmiller, Mark Y. Fang, David A. Nelles, Jennifer A. Doudna, Mitchell R. O’Connell
Publikováno v:
Cell, vol 165, iss 2
RNA-programmed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has enabled rapid and accessible alteration of specific genomic loci in many organisms. A flexible means to target RNA would allow alteration and imaging of endogenous RNA tr
Autor:
Katherine Licon, John Paul Shen, Ana Bojorquez-Gomez, Andrew M. Gross, Chu Ping Qiu, Huwate Yeerna, Jia L. Xu, Rohith Srivas, Haico van Attikum, Robert W. Sobol, Vignesh Sivaganesh, Su Ming Sun, Eric J. Jaehnig, Daniel Pekin, Jianfeng Li, Kristin Klepper, Trey Ideker
Publikováno v:
Oncotarget
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we
Autor:
Robert W. Sobol, Justin K. Huang, Trey Ideker, Jianfeng Li, Jia L. Xu, Ana Bojorquez-Gomez, Andrew M. Gross, James Jensen, Leonie Kollenstart, Rohith Srivas, Daniel Pekin, John Paul Shen, Haico van Attikum, Kristin Klepper, Vignesh Sivaganesh, Chih Cheng Yang, Su Ming Sun, Pedro Aza-Blanc, Huwate Yeerna, Katherine Licon
Publikováno v:
Molecular Cell, 63(3), 514-525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8619741cd89b289b24df77a20c39353
https://hdl.handle.net/1887/113262
https://hdl.handle.net/1887/113262
Autor:
Patrick Liu, Olga Botvinnik, Boyko Kakaradov, Jia L. Xu, Michael T. Lovci, Gene W. Yeo, Yan Song
Publikováno v:
Molecular Cell. 67:148-161.e5
Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in multicellular life. Although AS variation has been observed among single cells, little is known about the biological or evolutionary significance of such v
Autor:
John Paul Shen, Ana Bojorquez-Gomez, Jia L. Xu, Trey Ideker, Andrew M. Gross, Huwate Yeerna, Katherine Licon, Vignesh Sivaganesh, Rohith Srivas, Robert W. Sobol, Jianfeng Li
Publikováno v:
Cancer Research. 75:129-129
Synthetic lethal interactions are a type of genetic interaction in which the simultaneous loss of function of two genes in combination results in cell death. Recently, there has been much interest in the discovery of drugs that are selectively toxic