Výsledky vyhledávání - "Jia Jun Chia"

Akademický článek

Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and metabolized in multiple steps to form the active nucleoside triphosphate (GS-44

Externí odkaz: https://doaj.org/article/ee7f5fe788f0477a9009a8f32e4eeffd

Zobrazit plný text záznamu

Plný text ve formátu HTML

SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification

Autor: Cecilia M. Giachelli, Suhaib Borgeia, Mary C. Wallingford, Timothy C. Cox, Chenphop Sawangmake, Jia Jun Chia, Elizabeth M. Leaf, Kenneth I. Marro, Nicholas W. Chavkin, Mei Y. Speer

Publikováno v: Brain Pathology. 27:64-76

Idiopathic basal ganglia calcification is a brain calcification disorder that has been genetically linked to autosomal dominant mutations in the sodium-dependent phosphate co-transporter, SLC20A2. The mechanisms whereby deficiency of Slc20a2 leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c763bcfd585e567531ff009e510332a
https://doi.org/10.1111/bpa.12362

Zobrazit plný text záznamu

PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet

Autor: Shunsuke Yamada, Jia Jun Chia, Cecilia M. Giachelli, Mei Y. Speer, Elizabeth M. Leaf, Timothy C. Cox

Publikováno v: Kidney international. 94(4)

PiT-2, a type III sodium-dependent phosphate transporter, is a causative gene for the brain arteriolar calcification in people with familial basal ganglion calcification. Here we examined the effect of PiT-2 haploinsufficiency on vascular calcificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf8e838a15c4a4f84153cb6815ebf00
https://pubmed.ncbi.nlm.nih.gov/30243309

Zobrazit plný text záznamu

Phosphate Uptake-Independent Signaling Functions of the Type III Sodium-Dependent Phosphate Transporter, PiT-1, in Vascular Smooth Muscle Cells

Autor: Cecilia M. Giachelli, Jia Jun Chia, Matthew H. Crouthamel, Nicholas W. Chavkin

Vascular calcification (VC) is prevalent in chronic kidney disease and elevated serum inorganic phosphate (Pi) is a recognized risk factor. The type III sodium-dependent phosphate transporter, PiT-1, is required for elevated Pi-induced osteochondroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced6bef09ae4249c36b4607be83529ef
https://europepmc.org/articles/PMC4387109/

Zobrazit plný text záznamu

Actin Branching Is Affected by Local Bending of the Mother Filament

Autor: Ovijit Chaudhuri, Viviana I. Risca, Jia Jun Chia, Daniel A. Fletcher

Publikováno v: Biophysical Journal. (3):122a

Actin filaments serve as structural elements of the cytoskeleton subject to mechanical forces and provide binding sites for actin-binding proteins (ABPs). Structural studies have established that actin filaments can adopt several different twist stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33963feb53203b9d2a4a32caf39ce8d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání