Výsledky vyhledávání - "Jia Jia Zhang"

Akademický článek

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

Autor: Alireza Ghanbarpour, Steven E. Cohen, Xue Fei, Laurel F. Kinman, Tristan A. Bell, Jia Jia Zhang, Tania A. Baker, Joseph H. Davis, Robert T. Sauer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract AAA+ proteases degrade intracellular proteins in a highly specific manner. E. coli ClpXP, for example, relies on a C-terminal ssrA tag or other terminal degron sequences to recognize proteins, which are then unfolded by ClpX and subsequently

Externí odkaz: https://doaj.org/article/f72b46a348b247609e8481dbe950089a

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Akademický článek

Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria

Autor: Jia Jia Zhang, Xiaoyu Tang, Michelle Zhang, Darlene Nguyen, Bradley S. Moore

Publikováno v: mBio, Vol 8, Iss 5 (2017)

ABSTRACT Heterologous expression has become a powerful tool for studying microbial biosynthetic gene clusters (BGCs). Here, we extend the transformation-associated recombination cloning and heterologous expression platform for microbial BGCs to inclu

Externí odkaz: https://doaj.org/article/748b1cccf587411e8ba73b0dbd938e30

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Akademický článek

Digging for biosynthetic dark matter

Autor: Jia Jia Zhang, Bradley S Moore

Publikováno v: eLife, Vol 4 (2015)

An analysis of bacterial communities in soil samples from around the world reveals unexplored diversity in biosynthetic enzymes.

Externí odkaz: https://doaj.org/article/b2d6917ead5446dbb2dd83449cfb4232

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Akademický článek

Blockade of mIL‐6R alleviated lipopolysaccharide‐induced systemic inflammatory response syndrome by suppressing NF‐κB‐mediated Ccl2 expression and inflammasome activation

Autor: Ji‐Min Dai, Xue‐Qin Zhang, Jia‐Jia Zhang, Wei‐Jie Yang, Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen

Publikováno v: MedComm, Vol 3, Iss 2, Pp n/a-n/a (2022)

Abstract Systemic inflammatory response syndrome (SIRS) is characterized by dysregulated cytokine release, immune responses and is associated with organ dysfunction. IL‐6R blockade indicates promising therapeutic effects in cytokine release storm b

Externí odkaz: https://doaj.org/article/154e0c7013a14c5390f5645635429187

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Akademický článek

Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency

Autor: Yu-Shui Ma, Xiao-Feng Wang, Yun-Jie Zhang, Pei Luo, Hui-Deng Long, Liu Li, Hui-Qiong Yang, Ru-Ting Xie, Cheng-You Jia, Gai-Xia Lu, Zheng-Yan Chang, Jia-Jia Zhang, Shao-Bo Xue, Zhong-Wei Lv, Fei Yu, Qing Xia, Da Fu

Publikováno v: Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 147-157 (2020)

Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here, we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice. Speci

Externí odkaz: https://doaj.org/article/19e5d6bc50b64885983f3238c6b01f1b

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