Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jia Jia, Chan"'
Autor:
Yongkang Long, Bin Zhang, Shuye Tian, Jia Jia Chan, Juexiao Zhou, Zhongxiao Li, Yisheng Li, Zheng An, Xingyu Liao, Yu Wang, Shiwei Sun, Ying Xu, Yvonne Tay, Wei Chen, Xin Gao
Publikováno v:
Genome Research. 33:644-657
Alternative polyadenylation (APA) enables a gene to generate multiple transcripts with different 3′ ends, which is dynamic across different cell types or conditions. Many computational methods have been developed to characterize sample-specific APA
Autor:
Zhongxiao Li, Bin Zhang, Jia Jia Chan, Hossein Tabatabaeian, Qing Yun Tong, Xiao Hong Chew, Xiaonan Fan, Patrick Driguez, Charlene Chan, Faith Cheong, Shi Wang, Bei En Siew, Ian Jse-Wei Tan, Kai-Yin Lee, Bettina Lieske, Wai-Kit Cheong, Dennis Kappei, Ker-Kan Tan, Xin Gao, Yvonne Tay
SummaryColorectal cancer (CRC) is the second leading cause of cancer death worldwide. In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor cell heterogeneities. However, these studies only enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164d871344c44357378d920899e1d765
https://doi.org/10.1101/2023.04.21.536771
https://doi.org/10.1101/2023.04.21.536771
Autor:
Yvonne Tay, Dennis Kappei, Henry Yang, Velda Teh, Jia Jia Chan, Xiao Hong Chew, Bin Zhang, Zhi Hao Kwok
Approximately half of all miRNA reside within intronic regions and are often cotranscribed with their host genes. However, most studies of intronic miRNA focus on individual miRNA, while conversely most studies of protein-coding and noncoding genes f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63593126ebae55bca22377bbfb8d37d8
https://doi.org/10.1158/0008-5472.c.6512451
https://doi.org/10.1158/0008-5472.c.6512451
Autor:
Yvonne Tay, Dennis Kappei, Henry Yang, Velda Teh, Jia Jia Chan, Xiao Hong Chew, Bin Zhang, Zhi Hao Kwok
Figure S1 showing FTX-derived miRNAs are upregulated in colon cancer patients. Figure S2 showing FTX possesses oncogenic properties in colon cancer. Figure S3 showing FTX interacts with DHX9 and DICER. Figure S4 showing intronic miR-374b and -545 pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a417d9c5e9613090990c11f142bb9c5
https://doi.org/10.1158/0008-5472.22426788
https://doi.org/10.1158/0008-5472.22426788
Publikováno v:
Trends in cell biology.
The majority of human mRNAs generate alternative 3' untranslated regions (UTRs) through various processes, including RNA modifications such as RNA editing, m
Autor:
Dennis Kappei, Velda Teh, Henry Yang, Xiao Hong Chew, Yvonne Tay, Jia Jia Chan, Zhi Hao Kwok, Bin Zhang
Publikováno v:
Cancer Research. 81:1308-1320
Approximately half of all miRNA reside within intronic regions and are often cotranscribed with their host genes. However, most studies of intronic miRNA focus on individual miRNA, while conversely most studies of protein-coding and noncoding genes f
Autor:
Jia Jia Chan, Yvonne Tay
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 5, p 1310 (2018)
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and has been implicated in many pathological conditions, especially cance
Externí odkaz:
https://doaj.org/article/3b352789d131485d9207cc04bee4cdd0
Autor:
Ng Desi, Qing Yun Tong, Velda Teh, Jia Jia Chan, Bin Zhang, Hossein Tabatabaeian, Hui Qing Tan, Katannya Kapeli, Wenhao Jin, Chun You Lim, Zhi Hao Kwok, Hwee Tong Tan, Shi Wang, Bei-En Siew, Kuok-Chung Lee, Choon-Seng Chong, Ker-Kan Tan, Henry Yang, Dennis Kappei, Gene W. Yeo, Maxey Ching Ming Chung, Yvonne Tay
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(3)
In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingl
Autor:
Ng Desi, Velda Teh, Qing Yun Tong, Chun You Lim, Hossein Tabatabaeian, Xiao Hong Chew, Avencia Sanchez-Mejias, Jia Jia Chan, Bin Zhang, Priyankaa Pitcheshwar, Bei-En Siew, Shi Wang, Kuok-Chung Lee, Choon-Seng Chong, Wai-Kit Cheong, Bettina Lieske, Ian Jse-Wei Tan, Ker-Kan Tan, Yvonne Tay
Publikováno v:
Oncogene. 41(8)
3′UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present in cancer cells. One of the most wel
Autor:
Su Ying Lim, Xin Ni Lim, Kiat Yee Tan, Anna Karin Beatrice Sundstrom, Jing Zou, Hui Xian Poh, Wy Ching Ng, Eng Eong Ooi, October M. Sessions, Pei Yong Shi, Kuo-Chieh Liao, Jia Jia Chan, Roland G. Huber, Yvonne Tay, Xuping Xie, Yue Wan, Amanda Makha Bifani
Publikováno v:
SSRN Electronic Journal.
Identifying host factors is key to understanding RNA virus pathogenicity. Besides proteins, RNAs can interact with virus genomes to impact replication. Here, we used proximity ligation sequencing to identify virus-host RNA interactions for four strai