Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Jia DUAN"'
Autor:
Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H. Eric Xu, Jia Duan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114389- (2024)
Summary: Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable role in regulating reproduction via the hypothalamic-pituitary-gonadal axis. Dysregulation of this pathway underlies severe disorders like infertilit
Externí odkaz:
https://doaj.org/article/9c255df8d34046729b6af43aebba673c
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Macrophages activation and inflammatory response play crucial roles in intracranial aneurysm (IA) formation and progression. The outcome of ruptured IA is considerably poor, and the mechanisms that trigger IA progression and rupture remain to be clar
Externí odkaz:
https://doaj.org/article/87713e4fc33f4f389ae6f73b0b244453
Publikováno v:
Zhongguo Jianchuan Yanjiu, Vol 18, Iss 4, Pp 162-174 (2023)
In recent years, the problem of low-frequency line spectrum noise generated by the flow-induced cavity oscillation of underwater vehicles has become increasingly prominent as it seriously threatens stealth performance. Focusing on practical engineeri
Externí odkaz:
https://doaj.org/article/ce1135e945cc41b5967bcf7fba2b9b77
Publikováno v:
Sensors, Vol 24, Iss 9, p 2770 (2024)
Transient interference often submerges the actual targets when employing over-the-horizon radar (OTHR) to detect targets. In addition, modern OTHR needs to carry out multi-target detection from sea to air, resulting in the sparse sampling of echo dat
Externí odkaz:
https://doaj.org/article/c136cfa2d120485aa7450935501430fd
Autor:
Canrong Wu, Youwei Xu, Qian He, Dianrong Li, Jia Duan, Changyao Li, Chongzhao You, Han Chen, Weiliang Fan, Yi Jiang, H. Eric Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Prostaglandin F2α (PGF2α), an endogenous arachidonic acid metabolite, regulates diverse physiological functions in many tissues and cell types through binding and activation of a G-protein-coupled receptor (GPCR), the PGF2α receptor (FP),
Externí odkaz:
https://doaj.org/article/47b05886e76b4dfca9555b7c350fb9e2
Autor:
Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H. Eric Xu, Jia Duan
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113406- (2023)
Summary: Niacin, an age-old lipid-lowering drug, acts through the hydroxycarboxylic acid receptor 2 (HCAR2), a G-protein-coupled receptor (GPCR). Yet, its use is hindered by side effects like skin flushing. To address this, specific HCAR2 agonists, l
Externí odkaz:
https://doaj.org/article/a7636dc6ca5948eb89f4fb4f3d39c960
Autor:
Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.
Externí odkaz:
https://doaj.org/article/df95d5c76f0c49d4836771fc0c1cf969
Autor:
Jia Duan, Xiaohong Gong, Fay Y. Womer, Kaijin Sun, Lili Tang, Juan Liu, Junjie Zheng, Yue Zhu, Yanqing Tang, Xizhe Zhang, Fei Wang
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Schizophrenia (SZ) arises from a complex interplay involving genetic and molecular factors. Early intervention of SZ hinges upon understanding its vulnerability and resiliency factors in study of SZ and genetic high risk for SZ (G
Externí odkaz:
https://doaj.org/article/bb73ca8042f64fca9ef4a705c62556af
Publikováno v:
IET Radar, Sonar & Navigation, Vol 17, Iss 3, Pp 466-477 (2023)
Abstract Rotating antenna radar is widely used on the airborne platform to extend the range of the radar detection airspace. However, the echo signal received by an airborne rotating radar is spread in the Doppler domain due to the platform motion an
Externí odkaz:
https://doaj.org/article/e343ac2a47f04b7398c27b497df7743c
Autor:
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xinheng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shuyang Zhang, Yan Zhang, H. Eric Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al. report cryo-EM structures of FSHR in active and inactive states, suggesting the molecular basis
Externí odkaz:
https://doaj.org/article/856683e70c7b4674b3561a58992980ab