Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jia‐Nan Gong"'
Autor:
Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, Kwee Yong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We
Externí odkaz:
https://doaj.org/article/3f533fcbf74447e289791076e3a6c8ea
Autor:
Yumin Wei, Liping Zhang, Chao Wang, Zefeng Li, Mingjie Luo, Guomin Xie, Xingjiu Yang, Mengyuan Li, Shuyue Ren, Dongbing Zhao, Ran Gao, Jia‐Nan Gong
Publikováno v:
Animal Models and Experimental Medicine, Vol 6, Iss 3, Pp 245-254 (2023)
Abstract Background New therapeutic targets are needed to improve the outcomes for gastric cancer (GC) patients with advanced disease. Evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by tar
Externí odkaz:
https://doaj.org/article/d2b8ee01811642c5933027640e7981fe
Autor:
Anne Slomp, Laura M. Moesbergen, Jia-nan Gong, Marta Cuenca, Peter A. von dem Borne, Pieter Sonneveld, David C.S. Huang, Monique C. Minnema, Victor Peperzak
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4202-4214 (2019)
Abstract: Prosurvival BCL-2 family proteins are potent inhibitors of apoptosis and often overexpressed in lymphoid malignancies. In multiple myeloma (MM), MCL-1 expression contributes to survival of malignant plasma cells, and overexpression correlat
Externí odkaz:
https://doaj.org/article/491d7cc1157c435da48074ecbfbcb0f4
Autor:
Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman, Peter E. Czabotar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The BCL-2 mutation G101V reduces venetoclax affinity and confers drug resistance in patients with chronic lymphocytic leukaemia. Here, the authors present crystal structures and biochemical analyses of venetoclax bound to BCL-2 and the G101V mutant,
Externí odkaz:
https://doaj.org/article/972a06d765d140d0b0bfb95c8133217b
Autor:
Dao-Qi Wang, Yang-Tian Jiao, Le Ling, Jia-Xin Wang, Yong-Hua Niu, Zhe Tang, Yin-Wei Chen, Jia-Nan Gong, Tao Wang, Ji-Hong Liu, Qing Ling
Publikováno v:
Asian Journal of Andrology, Vol 23, Iss 3, Pp 333-334 (2021)
Externí odkaz:
https://doaj.org/article/a1423835969f427ea217f6314258e280
Autor:
Galas-Filipowicz, Daria, Chavda, Selina J., Jia-Nan Gong, Huang, David C. S., Khwaja, Asim, Kwee Yong
Publikováno v:
Frontiers in Oncology; 2024, p1-10, 10p
Autor:
Allan Shuai Huang, Hui San Chin, Boris Reljic, Tirta M. Djajawi, Iris K. L. Tan, Jia-Nan Gong, David A. Stroud, David C. S. Huang, Mark F. van Delft, Grant Dewson
Publikováno v:
Cell Death & Differentiation. 30:632-646
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29bc7463bc9ae13bbdd90a64372f139a
https://doi.org/10.1038/s41418-022-01067-z
https://doi.org/10.1038/s41418-022-01067-z
Autor:
Andrew W. Roberts, David C.S. Huang, Peter E. Czabotar, John F. Seymour, Constantine S. Tam, David A. Westerman, Daniel H.D. Gray, Ian J. Majewski, Thomas E. Lew, Christoffer Flensburg, Zhen Xu, Tamia Nguyen, Charis E. Teh, Ella R. Thompson, Richard W. Birkinshaw, Rachel Thijssen, Jia-nan Gong, Mary Ann Anderson, Piers Blombery
Supplementary Material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89a0cdbc3aa03a62b92183055427d1b
https://doi.org/10.1158/2159-8290.22532996.v1
https://doi.org/10.1158/2159-8290.22532996.v1
Autor:
Simon N. Willis, Charis E Teh, Yang Liao, Mark F. van Delft, Tania Tan, George Grigoriadis, Lorraine A. O'Reilly, Stephen L. Nutt, David C.S. Huang, Jia-Nan Gong, Julie Tellier, Michael S.Y. Low, Marco J Herold, Yuan Yao, Jacob T. Jackson, Wei Shi, Lin Tai, Pasquale L. Fedele
Publikováno v:
Leukemia. 35:2114-2118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d59ea7ff251473fc859c3cd730164ac9
https://doi.org/10.1038/s41375-020-01078-0
https://doi.org/10.1038/s41375-020-01078-0
Autor:
Jia-Nan Gong, Zhen Xu, Melissa J. Call, Ming-Jie Luo, Allan Shuai Huang, Lei Liu, Tirta Mario Djajawi, Mark F. van Delft, Toru Okamoto, David C. S. Huang
Publikováno v:
Cell Death and Differentiation
MCL1, a BCL2 relative, is critical for the survival of many cells. Its turnover is often tightly controlled through both ubiquitin-dependent and -independent mechanisms of proteasomal degradation. Several cell stress signals, including DNA damage and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae236e01f19c4e9eb50aff338b43848c
https://doi.org/10.1038/s41418-020-0517-0
https://doi.org/10.1038/s41418-020-0517-0