Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Ji-yang WANG"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/7f1bf2216661469884586cc722e833bb
Publikováno v:
工程科学学报, Vol 44, Iss 10, Pp 1682-1693 (2022)
Coal resources are non-renewable one-time energy. With the increase in mining depth, thermal energy is released with the exploitation of deep coal resources. It is renewable and clean, unaffected by environmental factors, and is an important part of
Externí odkaz:
https://doaj.org/article/9caf62a982014822976299bb8ccc23f9
Autor:
Qing Min, Krisztian Csomos, Yaxuan Li, Lulu Dong, Ziying Hu, Xin Meng, Meiping Yu, Jolan E. Walter, Ji-Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mutations in the recombination activating gene 1 (RAG1) and RAG2 in humans are associated with a broad spectrum of clinical phenotypes, from severe combined immunodeficiency to immune dysregulation. Partial (hypomorphic) RAG deficiency (pRD) in parti
Externí odkaz:
https://doaj.org/article/2c3714d87b45462698adacb97af335af
Autor:
Wenjie Wang, Qing Min, Nannan Lai, Krisztian Csomos, Ying Wang, Luyao Liu, Xin Meng, Jinqiao Sun, Jia Hou, Wenjing Ying, Qinhua Zhou, Bijun Sun, Xiaoying Hui, Boglarka Ujhazi, Sumai Gordon, David Buchbinder, Catharina Schuetz, Manish Butte, Jolan E. Walter, Xiaochuan Wang, Ji-Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundActivated phosphoinositide 3 kinase (PI3K) -delta syndrome (APDS) is an inborn error of immunity with variable clinical phenotype of immunodeficiency and immune dysregulation and caused by gain-of-function mutations in PIK3CD. The hallmark
Externí odkaz:
https://doaj.org/article/8c8365988a5549fb8f212dacf50ffa66
Autor:
Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V. Youngyunpipatkul, James B. Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G. Vilches-Moure, Denong Wang, Michael P. Snyder, Ji-Yang Wang, Jian Han, Leonore A. Herzenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.
Externí odkaz:
https://doaj.org/article/229a32c1fd3d4c71969347ac1499f7d4
Autor:
Qing Min, Xin Meng, Qinhua Zhou, Ying Wang, Yaxuan Li, Nannan Lai, Ermeng Xiong, Wenjie Wang, Shoya Yasuda, Meiping Yu, Hai Zhang, Jinqiao Sun, Xiaochuan Wang, Ji-Yang Wang
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Hypomorphic RAG1 or RAG2 mutations cause primary immunodeficiencies and can lead to autoimmunity, but the underlying mechanisms are elusive. We report here a patient carrying a c.116+2T>G homozygous splice site mutation in the first intron of RAG1, w
Externí odkaz:
https://doaj.org/article/45e62efa5e7f4f46860d57d96cda425f
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Immunoglobulin (Ig) M is the first antibody isotype to appear during evolution, ontogeny and immune responses. IgM not only serves as the first line of host defense against infections but also plays an important role in immune regulation and immunolo
Externí odkaz:
https://doaj.org/article/5817c30364504c6e883021c045d62730
Autor:
Hao Wei, Ji-Yang Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2284 (2021)
Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric immunoglobulin receptor (pIgR). Secreted IgA and IgM have vital roles i
Externí odkaz:
https://doaj.org/article/957b0a44f1f149619bd0137c43c707f3
Autor:
Yingqian Li, Yoshimasa Takahashi, Shin-ichiro Fujii, Yang Zhou, Rongjian Hong, Akari Suzuki, Takeshi Tsubata, Koji Hase, Ji-Yang Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
EAF2 has been previously known as a transcriptional elongation factor and a proapoptotic gene lost in prostate cancer. Here the authors show that EAF2 is required for apoptosis of germinal centre B cells, and that EAF2-deficient mice develop excessiv
Externí odkaz:
https://doaj.org/article/01bd65f796e8492f932b77a49da26010
Autor:
Jun Liu, Hanying Zhu, Jiawen Qian, Ermeng Xiong, Lumin Zhang, Yan-Qing Wang, Yiwei Chu, Hiromi Kubagawa, Takeshi Tsubata, Ji-Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The marginal zone B cells (MZB) are located at the interface between the circulation and lymphoid tissue and as a gatekeeper play important roles in both innate and adaptive immune responses. We have previously found that MZB are significantly reduce
Externí odkaz:
https://doaj.org/article/f8fab6d5b1aa4c0eb902851ed7b3249b