Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ji-sun Kwon"'
Autor:
Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lip
Externí odkaz:
https://doaj.org/article/8951e53b83a446a78dbb4875a502960b
Autor:
Ank Agarwal, Seongje Park, Shinwon Ha, Ji-Sun Kwon, Mohammed Repon Khan, Bong Gu Kang, Ted M Dawson, Valina L Dawson, Shaida A Andrabi, Sung-Ung Kang
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231978 (2020)
Ischemic strokes result in the death of brain tissue and a wave of downstream effects, often leading to lifelong disabilities or death. However, the underlying mechanisms of ischemic damage and repair systems remain largely unknown. In order to bette
Externí odkaz:
https://doaj.org/article/9162d4a1f398472f920915525885425b
Autor:
Dae-Hwan Kim, Janghyun Kim, Ji-Sun Kwon, Jaspreet Sandhu, Peter Tontonoz, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1671-1682 (2016)
The pathophysiologic continuum of non-alcoholic fatty liver disease begins with steatosis. Despite recent advances in our understanding of the gene regulatory program directing steatosis, how it is orchestrated at the chromatin level is unclear. PPAR
Externí odkaz:
https://doaj.org/article/18b9c449db374838bd542ea4be49b1e0
Autor:
Yoanne M. Clovis, So Yeon Seo, Ji-sun Kwon, Jennifer C. Rhee, Sujeong Yeo, Jae W. Lee, Seunghee Lee, Soo-Kyung Lee
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1642-1652 (2016)
During development, two cell types born from closely related progenitor pools often express identical transcriptional regulators despite their completely distinct characteristics. This phenomenon implies the need for a mechanism that operates to segr
Externí odkaz:
https://doaj.org/article/e99ca0113299409385c38e3eba844f82
Publikováno v:
Genomics & Informatics, Vol 11, Iss 3, Pp 135-141 (2013)
Gene set analysis is a powerful tool for interpreting a genome-wide association study result and is gaining popularity these days. Comparison of the gene sets obtained for a variety of traits measured from a single genetic epidemiology dataset may gi
Externí odkaz:
https://doaj.org/article/199d89e9ae1b4a95952fec1534c694e6
Publikováno v:
Genomics & Informatics, Vol 10, Iss 2, Pp 123-127 (2012)
Gene set analysis (GSA) is useful in interpreting a genome-wide association study (GWAS) result in terms of biological mechanism. We compared the performance of two different GSA implementations that accept GWAS p-values of single nucleotide polymorp
Externí odkaz:
https://doaj.org/article/77b7c8d39cca4866aaf6688aa91e515c
Autor:
Zhao Sun, Ji-Sun Kwon, Yudong Ren, Shawei Chen, Walker, Courtney K., Xinguo Lu, Cates, Kitra, Karahan, Hande, Sviben, Sanja, Fitzpatrick, James A. J., Valdez, Clarissa, Houlden, Henry, Karch, Celeste M., Bateman, Randall J., Chihiro Sato, Mennerick, Steven J., Diamond, Marc I., Jungsu Kim, Tanzi, Rudolph E., Holtzman, David M.
Publikováno v:
Science. 8/2/2024, Vol. 385 Issue 6708, p515-515. 1p. 1 Diagram.
Autor:
Zhao Sun, Ji-Sun Kwon, Yudong Ren, Shawei Chen, Kitra Cates, Xinguo Lu, Courtney K. Walker, Hande Karahan, Sanja Sviben, James A J Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M. Karch, Randall J. Bateman, Chihiro Sato, Steven J. Mennerick, Marc I. Diamond, Jungsu Kim, Rudolph E. Tanzi, David M. Holtzman, Andrew S. Yoo
Publikováno v:
bioRxiv
Alzheimer’s disease (AD) is a neurodegenerative disorder that primarily affects elderly individuals, and is characterized by hallmark neuronal pathologies including extracellular amyloid-β (Aβ) plaque deposition, intracellular tau tangles, and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440dc641ebbc5e84ef3406eda0d2562f
https://europepmc.org/articles/PMC10245934/
https://europepmc.org/articles/PMC10245934/
Autor:
Bong Gu Kang, Sung-Ung Kang, Jae Jin Kim, Ji-Sun Kwon, Jean-Philippe Gagné, Seo Yun Lee, Soyeon Kim, Karl L. Sangwon, Shinwon Ha, Jun Seop Jeong, Yun-Il Lee, Heng Zhu, Dongsan Kim, Guy G. Poirier, Ho Chul Kang, Valina L. Dawson, Ted M. Dawson
SUMMARYPoly(ADP-ribose) (PAR) plays a crucial role in intracellular signaling and scaffolding through covalent modification or non-covalent binding to target proteins. The non- covalent binding PARylome has not been extensively characterized. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a7f16b4c21dbffac2052f89b1abc23
https://doi.org/10.1101/2022.06.06.494829
https://doi.org/10.1101/2022.06.06.494829
Autor:
Lucia S. Capano, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji-Sun Kwon, Kyle F. Burbach, Nicolas R. Barthélemy, Susan G. Fox, Celeste M. Karch, Randall J. Bateman, Henry Houlden, Richard I. Morimoto, David M. Holtzman, Karen E. Duff, Andrew S. Yoo
Publikováno v:
Cell Stem Cell
Tau is a microtubule-binding protein expressed in neurons and the equal ratio between 4-repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function. Dysregulation of 3R:4R ratio causes tauopathy and human neurons that recapit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7771023a4f12112e71595a754e1f383b
https://doi.org/10.1016/j.stem.2022.04.018
https://doi.org/10.1016/j.stem.2022.04.018