Výsledky vyhledávání - "Ji-Ichiro Sasaki"

Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer

Autor: Akinobu Hamada, Hideyuki Saito, Sunao Ushijima, Sho Saeki, Norihiro Iwamoto, Shinji Fujii, Hiroto Kishi, Hiroshi Semba, Yukari Tsubata, Takeshi Isobe, Hirotsugu Kohrogi, Yuki Kai, Maki Urata, Ji Ichiro Sasaki, Megumi Inaba, Kosuke Kashiwabara

Publikováno v: Pharmacogenomics. 13:615-624

Aims: We analyzed the association of ABCB1 polymorphisms with erlotinib-induced toxicity and the pharmacokinetics in patients with non-small-cell lung cancer. Materials & methods: After erlotinib 150 mg was administered to 50 patients, ABCB1 polymorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f65ad4964a4fe3dcea8efe35346c67
https://doi.org/10.2217/pgs.11.176

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Relationship Between Functional Preservation after Segmentectomy and Volume-Reduction Effects after Lobectomy in Stage I Non-small Cell Lung Cancer Patients with Emphysema

Autor: Hirotsugu Kohrogi, Hiroaki Nomori, Ji Ichiro Sasaki, Kazuhiko Fujii, Kosuke Kashiwabara, Tsuyoshi Mori

Publikováno v: Journal of Thoracic Oncology. 4(9):1111-1116

Objectives To evaluate whether functional preservation after segmentectomy has a greater advantage of pulmonary functions than volume-reduction effects after lobectomy in patients with emphysema with clinical T1N0 non-small cell lung cancer (NSCLC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0282be62e3c0969c963bebd1841cea03

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Combined Evaluation of Postoperative Serum Levels of Carcinoembryonic Antigen Less than or Equal to 2.5 ng/ml and Absence of Vascular Invasion may Predict no Recurrence of Stage I Adenocarcinoma Lung Cancer

Autor: Ji Ichiro Sasaki, Hirotsugu Kohrogi, Syoh Saeki, Kosuke Kashiwabara, Masanobu Nomura

Publikováno v: Journal of Thoracic Oncology. 3:1416-1420

Study Objectives It has been reported that high levels of serum carcinoembryonic antigen (CEA) after surgery, or the presence of vascular invasion or both, are strong indicators of postoperative recurrence in patients with non-small cell lung cancer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9aca2a83e43ba15eacb2d9b1db054b
https://doi.org/10.1097/jto.0b013e31818dda85

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Pharmacokinetics of Amrubicin and Its Active Metabolite Amrubicinol in Lung Cancer Patients

Autor: Akinobu Hamada, Mitsuhiro Matsumoto, Ji Ichiro Sasaki, Isamu Okamoto, Yusuke Matsunaga, Hiroshi Watanabe, Asumi Hira, Eiji Moriyama, Hideyuki Saito, Hiroto Kishi

Publikováno v: Therapeutic Drug Monitoring. 28:76-82

Amrubicin, a synthetic 9-aminoanthracycline agent, was recently approved in Japan for treatment of small-cell lung cancer and non-small-cell lung cancer. Amrubicin is converted enzymatically to the C-13 hydroxy metabolite amrubicinol, which is active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fe97a5803b719c14e5d64b92474874
https://doi.org/10.1097/01.ftd.0000185771.82620.ee

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Myristoylation of the Fus1 Protein Is Required for Tumor Suppression in Human Lung Cancer Cells

Autor: Masahiko Nishizaki, Lin Ji, Jack A. Roth, Futoshi Uno, Edward N. Atkinson, Kai Xu, John D. Minna, Giovanni L. Carboni, Ji-Ichiro Sasaki, Masashi Kondo

Publikováno v: Cancer Research. 64:2969-2976

FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21.3 region that is deleted in many cancers. Using surface-enhanced laser desorption/ionization mass spectrometric analysis on an anti-Fus1-antibody-capture ProteinChip array,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8421e96588c35829ec639e29d93351
https://doi.org/10.1158/0008-5472.can-03-3702

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Identification of a novel human homolog of theDrosophiladlg, P-dlg, specifically expressed in the gland tissues and interacting with p55

Autor: Hideo Nakamura, Hideaki Miyake, Tamotsu Sudo, Norio Masuko, Yukitaka Ushio, Ji Ichiro Sasaki, Masato Kochi, Hideyuki Saya, Hiromasa Tsuiki, Tetsuro Morisaki

Publikováno v: FEBS Letters. 433:63-67

We have identified a novel human homolog of the Drosophila dlg tumor suppressor gene, termed P-dlg, which has been mapped at chromosome 10q23. Unlike other human dlg homologs, P-dlg is expressed in placenta and various gland tissues but not in brain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd77c8dfb170b96aa2dda0ffe5fbe685
https://doi.org/10.1016/s0014-5793(98)00882-5

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Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells

Autor: Emiko Sanematsu, Hideyuki Saito, Yukiko Maeda, Koji Yokoo, Hiroshi Watanabe, Akinobu Hamada, Ji Ichiro Sasaki, Junko Fujii, Asumi Hira

Publikováno v: Biochemical pharmacology. 75(4)

Amrubicin is a completely synthetic 9-aminoanthracycline agent for the treatment of lung cancer in Japan. The cytotoxicity of C-13 hydroxy metabolite, amrubicinol, is 10 to 100 times greater than that of amrubicin. The transporters responsible for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23eef799ad524dc379cee216cd757dd4
https://pubmed.ncbi.nlm.nih.gov/18054347

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JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells

Autor: Bingliang Fang, Fuminori Teraishi, John J. Davis, Fengqing Dong, Ji-Ichiro Sasaki, Lidong Zhang, Shuhong Wu, Wei Guo

Publikováno v: Cellular and molecular life sciences : CMLS. 62(19-20)

We recently identified two thiazolidin compounds, 5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone (MMPT) and 5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin (DBPT), that inhibit the growth of human non-small-cell lung and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a237603677d37f24586adc3e8e973b95
https://pubmed.ncbi.nlm.nih.gov/16179969

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Efficacy of the tyrosine kinase inhibitor gefitinib in a patient with metastatic small cell lung cancer

Autor: Ji Ichiro Sasaki, Yasuko Ichikawa, Isamu Okamoto, Ryuichiro Suto, Jun Araki

Publikováno v: Lung cancer (Amsterdam, Netherlands). 48(1)

Gefitinib (Iressa, ZD1839) is an orally active inhibitor selective for the epidermal growth factor receptor tyrosine kinase and has shown promise in the treatment of non-small cell lung cancer (NSCLC). There has been no report to date of the effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4026d2335be0876adc5196fa4d4377
https://pubmed.ncbi.nlm.nih.gov/15777982

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Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells

Autor: Bingliang Fang, Masahiko Nishizaki, Lin Ji, Edward N. Atkinson, John D. Minna, Jack A. Roth, Ji Ichiro Sasaki

Publikováno v: Cancer research. 64(16)

Aberrations of the tumor suppressor genes FHIT and p53 are frequently associated with a wide range of human cancers, including lung cancer. We studied the combined effects of FHIT and p53 proteins on tumor cell proliferation and apoptosis in human no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf375dc90f6ec12dd5911b2fcfa54d1
https://pubmed.ncbi.nlm.nih.gov/15313915

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