The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigeminal nucleus caudalis of mice with infraorbital nerve injury

Autor: Ji-Hee Yeo, Dae-Hyun Roh

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Neuropathic pain caused by trigeminal nerve injury is a typical refractory orofacial chronic pain accompanied by the development of hyperalgesia and allodynia. We previously demonstrated that the mammalian target of rapamycin (mTOR) inhibitor rapamyc

Externí odkaz: https://doaj.org/article/afa18130a0a243e1b8be52554a7e6cc5

Dexmedetomidine Co-Administered with Lidocaine Decreases Nociceptive Responses and Trigeminal Fos Expression without Motor Dysfunction and Hypotension in a Murine Orofacial Formalin Model

Autor: Ji-Hee Yeo, Dae-Hyun Roh

Publikováno v: Life, Vol 12, Iss 2, p 215 (2022)

Administration of dexmedetomidine significantly induces sedation and anti-nociception in several nociceptive models, but clinical trials are restricted due to adverse side effects, including lethargy, hypotension, and bradycardia. Herein, we investig

Externí odkaz: https://doaj.org/article/7ce56cde721c4456bfdbb68156872baf

Rapamycin reduces orofacial nociceptive responses and microglial p38 mitogen-activated protein kinase phosphorylation in trigeminal nucleus caudalis in mouse orofacial formalin model

Autor: Dae Hyun Roh, Ji Hee Yeo, Sol Ji Kim

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

The mammalian target of rapamycin (mTOR) plays a role in various cellular phenomena, including autophagy, cell proliferation, and differentiation. Although recent studies have reported its involvement in nociceptive responses in several pain models,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa283534b102e715031b40ac3d3b6050
https://doi.org/10.4196/kjpp.2021.25.4.365

Analgesic Efficacy of α

Autor: Seo-Yeon, Yoon, Dae-Hyun, Roh, Ji-Hee, Yeo, Jiwan, Woo, Se Hee, Han, Key-Sun, Kim

Publikováno v: Neuroscience. 455

The analgesic effect of alpha-2 adrenergic receptor (α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26a8d9ebab12360e0aea6f6d145b7e4f
https://pubmed.ncbi.nlm.nih.gov/33359660

Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension

Autor: Alvin J. Beitz, Ji Hee Yeo, Dae Hyun Roh, Seog Bae Oh, Sol Ji Kim, Seo Yeon Yoon, Jang Hern Lee

Publikováno v: International Journal of Cancer. 138:2466-2476

Cancer chemotherapy with platinum-based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We evaluated the antinociceptive effects of the alpha-2 adrenoceptor agonist, clonidine on oxa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b351fc066509e8498cc242c930017df1
https://doi.org/10.1002/ijc.29980