Functional Diversity of p53 in Human and Wild Animals

Autor: Yi Li, Meng-Chen Zhang, Xiao-Kang Xu, Yang Zhao, Chatoo Mahanand, Tao Zhu, Hong Deng, Eviatar Nevo, Ji-Zeng Du, Xue-Qun Chen

Publikováno v: Frontiers in Endocrinology, Vol 10 (2019)

The common understanding of p53 function is a genome guardian, which is activated by diverse stresses stimuli and mediates DNA repair, apoptosis, and cell cycle arrest. Increasing evidence has demonstrated p53 new cellular functions involved in abund

Externí odkaz: https://doaj.org/article/919d2b00f10045748b5af82c8533ec42

IGFBP2 Plays an Essential Role in Cognitive Development during Early Life

Autor: Shumsuzzaman Khan, Yi Li, Minchao Lv, Nicholas C. Spitzer, Zhi Yang, Meng-Chen Zhang, Ji-Zeng Du, Shuangshuang Liu, Xiao-Kang Xu, Fangyuan Xia, Xin-Jiang Lu, Jian Weng, Xue-Qun Chen, Gareth Leng, Qingyao Huang, Jia-Wei Tang

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany), vol 6, iss 23
Advanced Science, Vol 6, Iss 23, Pp n/a-n/a (2019)
Khan, S, Lu, X, Huang, Q, Tang, J, Weng, J, Yang, Z, Lv, M, Xu, X, Xia, F, Zhang, M, Li, Y, Liu, S, Leng, G, Spitzer, N, Du, J & Chen, X 2019, ' IGFBP2 Plays an Essential Role in Cognitive Development during Early Life ', Advanced Science, vol. 6, no. 23, pp. 1901152 . https://doi.org/10.1002/advs.201901152
Advanced Science

Identifying the mechanisms underlying cognitive development in early life is a critical objective. The expression of insulin‐like growth factor binding protein 2 (IGFBP2) in the hippocampus increases during neonatal development and is associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5293330008a6b3e85d378181a6c0a81a
https://escholarship.org/uc/item/3pj8t9cb

The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP–protein kinase A signalling pathway in white adipose tissue

Autor: Mintao Song, Xue-Qun Chen, Ji-Zeng Du, Nan Chen, Zhuan Qu, Cheng-Li Xu, Yan-Lei Xiong, Hui Gong

Publikováno v: Molecular and Cellular Endocrinology. 392:106-114

Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue (WAT) regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to hypoxia. We found that hypobaric hypoxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9ff93d67842eafa7b770ea39f8701a
https://doi.org/10.1016/j.mce.2014.05.012

CRHR1 mediates p53 transcription induced by high altitude hypoxia through ERK 1/2 signaling in rat hepatic cells

Autor: Ming-Yang Wang, Ji-Zeng Du, Xue-Qun Chen, Ke Hao, Yang Zhao

Publikováno v: Peptides. 44:8-14

We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176a3a8177ff8079ffed7d8325a6300d
https://doi.org/10.1016/j.peptides.2013.03.023

Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax

Autor: Kexin Li, Yang Zhao, Zhi Yang, Eviatar Nevo, Ji-Zeng Du, Ji-Long Ren, Xue-Qun Chen, Yuval Ben-Abu, Jia-Wei Tang, Yi-Bin Cao

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(8)

Epigenetic modifications play significant roles in adaptive evolution. The tumor suppressor p53, well known for controlling cell fate and maintaining genomic stability, is much less known as a master gene in environmental adaptation involving methyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b023e3d64a2bf7db4f5341a91544175
https://pubmed.ncbi.nlm.nih.gov/26858405