Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ji Youn Nam"'
Autor:
Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Skovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T Cole, Priscille Brodin
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000645 (2009)
A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tub
Externí odkaz:
https://doaj.org/article/99417d33f11047f2814f85afb272f7e0
Autor:
Song-Hae Bok, Kwang-Hee Son, Soo-Kyung Kim, Ji-Youn Nam, Young Kook Kim, Sung-Uk Kim, Byoung-Mog Kwon, Tae Sook Jeong, Seung-Ho Lee, Kyou Hoon Han
Publikováno v:
Tetrahedron Letters. 36:6487-6490
KRIBB-BP005m, A novel tetracyclic compound containing a lactone which inhibits cholesteryl ester transfer protein (CETP), was isolated from a culture broth of Trichothecium roseum F1064 and the structure of KRIBB-BP005m was elucidated on the basis of
Publikováno v:
ChemInform. 27
We have isolated cholesteryl ester transfer protein (CETP) inhibitors from the extract of Korean Panax ginseng C. A. Meyer roots and identified them as polyacetylene analogs. These compounds inhibit human CETP with IC50 values of around 20-35 mg/ml.
Autor:
Ji-Youn Nam, Kwang-Hee Son, Hyae-Kyeong Kim, Song Hae Bok, Mi Young Han, Sung-Uk Kim, Yong Je Chung, Byoung-Mog Kwon
Publikováno v:
ChemInform. 29
Actinomycin D, C 2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC 50 5–7 μM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural li
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 315(3)
Roflumilast, a potent and selective phosphodiesterase 4 (PDE4) inhibitor, has been demonstrated to be an effective anti-inflammatory agent in airway inflammatory diseases. In the present study, we investigated the mechanism of anti-inflammatory effec
8-O-Methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor
Autor:
Un Chul Lee, Ji-Youn Nam, Mi Young Han, Hyae-Kyeong Kim, Kwang-Hee Son, Ju-Young Kwon, Byoung-Mog Kwon, Jung-Do Choi
Publikováno v:
Journal of natural products. 63(9)
A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding betw
Autor:
Fusao Takusagawa, Byoung-Mog Kwon, Mi Young Han, Jung Do Choi, Yafei Huang, Ji Youn Nam, Hyae Kyeong Kim, Hana L. Takusagawa, Kwang Hee Son
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(13)
Natural analogues (D, C2, and VII) of actinomycin inhibit Grb2 SH2 domain binding with phosphopeptide-derived from Shc in vitro and in intracellular system. To study structure-activity relationships, 13 actinomycin analogues were synthesized and we f
Autor:
Mi Young Han, Song Hae Bok, Byoung-Mog Kwon, Jung Do Choi, Ji Youn Nam, Eun Kyung Lee, Hyae Kyeong Kim
Publikováno v:
FEBS letters. 453(1-2)
Actinomycins, a family of bicyclic chromopeptide lactones with strong antineoplastic activity, were screened as inhibitors of Shc/Grb2 interaction in in vitro assay systems. To investigate the effects of actinomycin D on Shc/Grb2 interaction in cell-
Autor:
Hyae-Kyeong Kim, Ji-Youn Nam, Yong Je Chung, Kwang-Hee Son, Sung-Uk Kim, Song Hae Bok, Byoung-Mog Kwon, Mi Young Han
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(15)
Actinomycin D, C 2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC 50 5–7 μM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural li
Autor:
Song Hae Bok, Young Kook Kim, Ji Youn Nam, Sook-Hee Ro, Ihn-Rhan Lee, Hyun-Ju Jung, Byoung-Mog Kwon, Mi Kyung Kim
Publikováno v:
Planta medica. 63(6)
In the course of our screening program for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol,