Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Ji She"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113819- (2024)
Summary: Antibody inhibitors of the interleukin-6 (IL-6) signaling pathway, such as tocilizumab and sarilumab, have been used to treat rheumatoid arthritis, chimeric antigen receptor T cell-induced cytokine storm, and severe COVID-19 pneumonia. Here,
Externí odkaz:
https://doaj.org/article/ea5fc3c4e36e473ebc0b960e838b497d
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Sodium-dependent vitamin C transporters are responsible for vitamin C uptake and tissue distribution in mammals. Here, authors present cryo-EM structures of mouse SVCT1 in both the apo and substrate-bound states, revealing the structural basis of sub
Externí odkaz:
https://doaj.org/article/71e672d13e3e4637a0c50aad69d46cdc
Publikováno v:
eLife, Vol 9 (2020)
Mitochondrial Ca2+ uptake is mediated by an inner mitochondrial membrane protein called the mitochondrial calcium uniporter. In humans, the uniporter functions as a holocomplex consisting of MCU, EMRE, MICU1 and MICU2, among which MCU and EMRE form a
Externí odkaz:
https://doaj.org/article/15562b7063c9460c9243f34649d686c5
Publikováno v:
eLife, Vol 8 (2019)
The otopetrin (OTOP) proteins were recently characterized as proton channels. Here we present the cryo-EM structure of OTOP3 from Xenopus tropicalis (XtOTOP3) along with functional characterization of the channel. XtOTOP3 forms a homodimer with each
Externí odkaz:
https://doaj.org/article/49b9fad565e5497ba2d3b0d2409bbbfa
Publikováno v:
eLife, Vol 8 (2019)
Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligan
Externí odkaz:
https://doaj.org/article/55bfa42d23844a81bd020fd32b23acbb
Publikováno v:
Entropy, Vol 19, Iss 8, p 397 (2017)
This paper presents a novel low probability of intercept (LPI) optimization framework in radar network by minimizing the Schleher intercept factor based on minimum mean-square error (MMSE) estimation. MMSE of the estimate of the target scatterer matr
Externí odkaz:
https://doaj.org/article/7c52ea88755f414f9cd947ece62a26ef
Publikováno v:
Sensors, Vol 16, Iss 12, p 2193 (2016)
Radar networks are proven to have numerous advantages over traditional monostatic and bistatic radar. With recent developments, radar networks have become an attractive platform due to their low probability of intercept (LPI) performance for target t
Externí odkaz:
https://doaj.org/article/32f2ccbbd3c24107ade8ad5e6d7da2f6
Publikováno v:
Handbook of experimental pharmacology.
Two-pore channels (TPCs) belong to the family of voltage-gated tetrameric cation channels and are ubiquitously expressed in organelles of animals and plants. These channels are believed to be evolutionary intermediates between homotetrameric voltage-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a90d38a43fca748c0aa76d2ee9a3c060
https://pubmed.ncbi.nlm.nih.gov/35879575
https://pubmed.ncbi.nlm.nih.gov/35879575
Publikováno v:
电力工程技术, Vol 43, Iss 5, Pp 199-207 (2024)
Iron-based soft magnetic composites have the characteristics of high magnetic permeability, high magnetic induction strength and low iron loss. It is of great significance to study the vibration and noise characteristics of this material reactor for
Externí odkaz:
https://doaj.org/article/24eeb0be05d848f4a304354fcc67d40f
Autor:
Minhao Tang, Ji Shen, Yiding Wang, Yanfei Zhao, Tao Gan, Xusheng Zheng, Dingsheng Wang, Buxing Han, Zhimin Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The chemical recycling of polyester wastes is of great significance for sustainable development, which also provides an opportunity to access various oxygen-containing chemicals, but generally suffers from low efficiency or separation diffic
Externí odkaz:
https://doaj.org/article/29237f8c915249c48054470d487e398c