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CJ14939, a Novel JAK Inhibitor, Increases Oxaliplatin-induced Cell Death Through JAK/STAT Pathway in Colorectal Cancer

Publikováno v: Anticancer Research. 42:1813-1819

Colorectal cancer is reported to have the highest mortality rate among human malignancies. Although many research results for the treatment of colorectal cancer have been reported, there is no suitable treatment when resistance has developed. Therefo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6c0a558923227aa2afaf187e67e1a4
https://doi.org/10.21873/anticanres.15657

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Inhibition of JAK1/2 can overcome EGFR-TKI resistance in human NSCLC

Publikováno v: Biochemical and biophysical research communications. 527(1)

Non-small lung cancer (NSCLC) is the most common cancer in the world. The epidermal growth factor receptor (EGFR) gene is mutated in approximately 10% of lung cancer cases in the US and 50% of lung cancer in Asia. The representative target therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b444b7bcf02977a88d1521883de752e4
https://pubmed.ncbi.nlm.nih.gov/32446385

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Human breast cancer cells display different sensitivities to ABT-263 based on the level of survivin

Autor: Hyun Jae Shim, Seul Lee, Dong-Hoon Jin, Yoon Sun Park, Jae-Sik Shin, Ji-min Shin, Eun-Yeung Gong, Dae Hee Lee, Eun Young Lee, Mi Jin Kim, Ji Hee Gong, Jai-Hee Moon, Joonyee Jeong, Yeong Seok Kim, Seung Woo Hong, Seung-Mi Kim

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 46

ABT-263 (navitoclax), a Bcl-2 family protein inhibitor, was clinically tested as an anti-cancer agent. However, the clinical trials were limited given the occurrence of resistance to monotherapy in breast cancer cells. Our study investigates the mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609c15df7891dd2457857e04cf5a3e54
https://pubmed.ncbi.nlm.nih.gov/28947240

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GSK-3β-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63

Autor: Ga Bin Park, Yoon Hee Chung, Daejin Kim, Dong-Hoon Jin, Ji Hee Gong

Publikováno v: International journal of oncology. 49(5)

Glycogen synthase kinase-3β (GSK-3β) in cancer cells is a critical regulatory component of both cellular metabolism and epithelial-mesenchymal transition (EMT) processes via regulation of the β-catenin/E-cadherin and phosphoinositide 3-kinase (PI3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fd62c58e671f7d4f5ece4f70caccf3
https://pubmed.ncbi.nlm.nih.gov/27599658

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Abstract 2909: Development of new mechanism based therapeutic antibodies in non-small cell lung cancer

Publikováno v: Cancer Research. 78:2909-2909

Lung cancer is second most common cancer in the world. Non Small Cell Lung Cancer (NSCLC) accounts approximately 80-85% of all lung cancer diagnosis. Traditional therapies of this disease were surgical resection, chemotherapy, and radiotherapy, alone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc5156f0ffd2ae54151f6e4cda7b2912
https://doi.org/10.1158/1538-7445.am2018-2909

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Abstract 2669: Identification of a novel small-molecule inhibitor for treatment of human colon cancer patients

Publikováno v: Cancer Research. 78:2669-2669

As the representative targeted anticancer drug for colon cancer patients, Erbitux is the EGFR targeted therapeutic antibody and used for treatment of KRAS wild-type colon cancer patients. Even some patients with KRas wt gene did not respond to Erbitu

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https://doi.org/10.1158/1538-7445.am2018-2669

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Structural basis for the recognition of lysozyme by MliC, a periplasmic lysozyme inhibitor in Gram-negative bacteria

Autor: Kwang Min Choe, Ji Hee Gong, Moon Jong Kim, Soohwan Yum, Yongbin Xu, Bok Luel Lee, Nam-Chul Ha, Hee Young Yoo, Ji Won Park, Xiao Ling Jin

Publikováno v: Biochemical and Biophysical Research Communications. 378:244-248

Lysozymes are an important component of the innate immune system of animals that hydrolyze peptidoglycan, the major bacterial cell wall constituent. Many bacteria have contrived various means of dealing with this bactericidal enzyme, one of which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb26bb9303d9db28a3749410d1116361
https://doi.org/10.1016/j.bbrc.2008.11.039

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Biochemical characterization of evasion from peptidoglycan recognition by Staphylococcus aureus D-alanylated wall teichoic acid in insect innate immunity

Autor: Min-Su Kim, Bok Luel Lee, Kyoung-Hwa Ryu, Lili Zheng, Jun-Ho Chae, Kenji Kurokawa, Ji-Hee Gong

Publikováno v: Developmental and comparative immunology. 35(8)

We recently reported that D-alanylation of Staphylococcus aureus wall teichoic acid (WTA) mitigates an induction of the Toll-mediated humoral response in Drosophila by interfering with peptidoglycan (PG) recognition by PG recognition protein-SA (PGRP

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https://pubmed.ncbi.nlm.nih.gov/21453720

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Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus

Autor: Ji Hee Gong, Bok Luel Lee, Akiko Shiratsuchi, Kenji Kurokawa, Kazuhisa Sekimizu, Yoshinobu Nakanishi, Yukichika Tabuchi

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 185(4)

Pathogenic bacteria mitigate host immunity to establish infections, but the mechanism of this bacterial action has not been fully elucidated. To search for cell wall components that modulate innate immune responses in host organisms, we examined Stap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6595ba4e5d1d760b1865730abdf70676
https://pubmed.ncbi.nlm.nih.gov/20639481

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