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Potent Growth Inhibition of Leukemic Cells by Novel Ribbon-type Antisense Oligonucleotides to c-myb1
Autor:
Ji Eyon Kim, Young Kook Choi, Kyu Sam Choi, Jong-Gu Park, Young Ik Lee, Ik Jae Moon, Alan D. Schreiber
Publikováno v:
Journal of Biological Chemistry. 275:4647-4653
We studied the effects of antisense oligonucleotides (AS oligos) with a novel structure. The AS oligos were covalently closed to avoid exonuclease activities by enzymatic ligation of two identical molecules. The AS oligos of a ribbon type (RiAS oligo