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Akademický článek

Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H2AX, CHK2 and p53

Autor: Ji-Hyun Kim, Eunji Im, Jihyun Lee, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Hyeon Hee Kwon, Bum Sang Shim, Bonglee Kim, Sung-Hoon Kim

Publikováno v: Cells, Vol 11, Iss 8, p 1343 (2022)

Herein, the apoptotic mechanism of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) was examined in cisplatin-resistant lung cancer cells. PGG significantly reduced viability; increased sub-G1 accumulation and the number of terminal deoxynucleotidy

Externí odkaz: https://doaj.org/article/d927a0e7965d45cd951227a92a7fcc9d

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Akademický článek

Apoptotic Effect of Brassinin via Inhibition of CNOT2 and Activation of p53 and Its Combination Effect with Doxorubicin

Autor: Woon Yi Park, Ji Eon Park, Ji Hoon Jung

Publikováno v: Applied Sciences, Vol 11, Iss 21, p 10036 (2021)

Brassinin derived from Chinese cabbage has been reported to act as an anti-cancer agent on prostate, liver, and colon cancer cells. However, its mechanism and impact are largely unknown in colon cancer cells. Here, we first published a report that Br

Externí odkaz: https://doaj.org/article/0cdb50ba3ba141e1aa2be3bb7fd352a8

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Akademický článek

Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells

Autor: Oh Sung Kwon, Ji Hoon Jung, Eun Ah Shin, Ji Eon Park, Woon Yi Park, Sung-Hoon Kim

Publikováno v: Biomedicines, Vol 8, Iss 4, p 84 (2020)

Though epigallocatechin-3-gallate (EGCG), a major compound of green tea, has anti-diabetes, anti-obesity, anti-inflammatory, and antitumor effects, the underlying antitumor molecular mechanism of EGCG was not fully understood so far. Here the sensiti

Externí odkaz: https://doaj.org/article/4250180c2eab4dab801c96312dbb579a

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Antioxidant-Based Preventive Effect of Phytochemicals on Anticancer Drug-Induced Hepatotoxicity

Autor: Ji Eon Park, Chi-Hoon Ahn, Hyo-Jung Lee, Deok Yong Sim, Su Yeon Park, Bonglee Kim, Bum Sang Shim, Dae Young Lee, Sung-Hoon Kim

Publikováno v: Antioxidants & Redox Signaling. 38:1101-1121

Drug induced liver injury (DILI) or hepatotoxicity has been a hot issue to overcome on the safety and physiological function of liver, since it is known to have biochemical, cellular, immunological and molecular alterations in liver mainly induced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e474ac4d305c5139187e2b773e5cad
https://doi.org/10.1089/ars.2022.0144

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