Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ji Dung Luo"'
Publikováno v:
eLife, Vol 12 (2023)
5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. The mammalian SNF2 family ATPase HELLS and its plant ortholog DDM1 are critical for maintaining 5mC. Mutation
Externí odkaz:
https://doaj.org/article/525be455114744679bd3c58d6d251a56
Autor:
Ji Dung Luo, 駱紀東
104
Colon cancer is highly prevalent in the worldwide. The mechanisms of tumor initiation, progression, recurrence and drug-resistance have been documented. However, the genetic alterations in tumors are highly divergent from patient to patient.
Colon cancer is highly prevalent in the worldwide. The mechanisms of tumor initiation, progression, recurrence and drug-resistance have been documented. However, the genetic alterations in tumors are highly divergent from patient to patient.
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/bqqyvg
Autor:
Chun-Hsu Pan, Shu-Chen Chien, Chang-Jui Chen, Chun-Ming Shih, Ming-Hsiung Hsieh, Chun-Yao Huang, Wei-Fung Bi, Chao-Shun Chan, Yung-Ta Kao, Cheng-Yi Hsiao, Shuo-Ju Chiang, Kuang-Hsing Chiang, Jen-Hung Huang, Yun-Ru Liu, Ji-Dung Luo, Hui-Yu Huang, Chieh-Hsi Wu
Publikováno v:
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background Patients who receive percutaneous coronary intervention (PCI) have different chances of developing in-stent restenosis (ISR). To date, no predictable biomarker can be applied in the clinic. MicroRNAs (miRNAs or miRs) play critical
Externí odkaz:
https://doaj.org/article/28b563f3da134c64b478cb0c6cfb6513
Autor:
Ji Dung Luo, 駱紀東
96
Uric acid is the end product of human purine metabolism and acts as a major antioxidant in body fluid. Xanthine oxidoreductase (XOR), the key enzyme of uric acid synthesis, has been shown to be induced by environmental stress, such as mechani
Uric acid is the end product of human purine metabolism and acts as a major antioxidant in body fluid. Xanthine oxidoreductase (XOR), the key enzyme of uric acid synthesis, has been shown to be induced by environmental stress, such as mechani
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/66492004170182169540
Autor:
Francesco M Piccolo, Nathaniel R Kastan, Tomomi Haremaki, Qingyun Tian, Tiago L Laundos, Riccardo De Santis, Andrew J Beaudoin, Thomas S Carroll, Ji-Dung Luo, Ksenia Gnedeva, Fred Etoc, AJ Hudspeth, Ali H Brivanlou
Publikováno v:
eLife, Vol 11 (2022)
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling has been s
Externí odkaz:
https://doaj.org/article/8b46541e954746688295c6c440a4599c
Autor:
Xiaojing Huang, Olivia A. Maguire, Jeanne M. Walker, Caroline S. Jiang, Thomas S. Carroll, Ji-Dung Luo, Emily Tonorezos, Danielle Novetsky Friedman, Paul Cohen
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
BACKGROUND Childhood cancer survivors who received abdominal radiotherapy (RT) or total body irradiation (TBI) are at increased risk for cardiometabolic disease, but the underlying mechanisms are unknown. We hypothesize that RT-induced adipose tissue
Externí odkaz:
https://doaj.org/article/ee581d06fb6a45e7a81f43d96e05c275
Autor:
An‐Ko Chung, Chun‐Nan OuYang, Hsuan Liu, Mei Chao, Ji‐Dung Luo, Cheng‐Yang Lee, Yen‐Jung Lu, I‐Che Chung, Lih‐Chyang Chen, Shao‐Min Wu, Ngan‐Ming Tsang, Kai‐Ping Chang, Cheng‐Lung Hsu, Hsin‐Pai Li, Yu‐Sun Chang
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5116-5127 (2019)
Abstract Approximately, 25% of nasopharyngeal carcinoma (NPC) patients develop recurrent disease. NPC may involve relatively few genomic alterations compared to other cancers due to its association with Epstein‐Barr virus (EBV). We envisioned that
Externí odkaz:
https://doaj.org/article/f8ef00ee3b1f461d9a6f56fe509e7a7e
Autor:
Andrew L. H. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Remco M. Hoogenboezem, Moonjung Jung, Sunandini Sridhar, Tom F. Wiley, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer A. Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas S. Carroll, Sanjana Shroff, Michael Beaumont, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Kristin G. Beaumont, Amnon Koren, Marcin Imielinski, Settara C. Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David I. Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Nature, 612(7940), 495-502. Nature Publishing Group
Nature
Nature
Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1–3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4
Autor:
Linghe Xi, Thomas Carroll, Irina Matos, Ji-Dung Luo, Lisa Polak, H Amalia Pasolli, Samie R Jaffrey, Elaine Fuchs
Publikováno v:
eLife, Vol 9 (2020)
N6-methyladenosine is the most prominent RNA modification in mammals. Here, we study mouse skin embryogenesis to tackle m6A’s functions and physiological importance. We first landscape the m6A modifications on skin epithelial progenitor mRNAs. Cont
Externí odkaz:
https://doaj.org/article/701021811dfb44fe9ddeb33838e2cf41
Publikováno v:
Nature. 609:761-771
Infections induce a set of pleiotropic responses in animals, including anorexia, adipsia, lethargy and changes in temperature, collectively termed sickness behaviours1. Although these responses have been shown to be adaptive, the underlying neural me