Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jiřina Vávrová"'
Autor:
Emilie Lukášová, Martina Řezáčová, Alena Bačíková, Ludmila Šebejová, Jiřina Vávrová, Stanislav Kozubek
Publikováno v:
FEBS Open Bio, Vol 9, Iss 5, Pp 870-890 (2019)
Replication stress (RS) is a major driver of genomic instability and tumorigenesis. Here, we investigated whether RS induced by the nucleotide analog fludarabine and specific kinase inhibitors [e.g. targeting checkpoint kinase 1 (Chk1) or ataxia tela
Externí odkaz:
https://doaj.org/article/c563f6f53d56495781761a7986de7d6a
Autor:
Barbora Šalovská, Ivo Fabrik, Kamila Ďurišová, Marek Link, Jiřina Vávrová, Martina Řezáčová, Aleš Tichý
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 12007-12026 (2014)
DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR)—triggered by radiation-induced double strand breaks—is orchestrated mainly by three Phosphatidylinositol 3-kinase-related ki
Externí odkaz:
https://doaj.org/article/8ce069f05b3546da89e01d2e7fa5020b
Autor:
Aleš Tichý, Eva Novotná, Kamila Ďurišová, Barbora Šalovská, Radka Sedlaříková, Jaroslav Pejchal, Lenka Zárybnická, Jiřina Vávrová, Zuzana Šinkorová, Martina Řezáčová
Publikováno v:
Acta Medica, Vol 55, Iss 2, Pp 66-73 (2012)
In this paper we describe the influence of NU7026, a specific inhibitor of DNA-dependent protein kinase, phosphoinositide 3-kinase, and ATM-kinase on molecular and cellular mechanisms triggered by ionising irradiation in human T-lymphocyte leukaemic
Externí odkaz:
https://doaj.org/article/863ee596f9ea4c379f25b2410648c158
Publikováno v:
Acta Medica, Vol 53, Iss 1, Pp 13-17 (2010)
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, c
Externí odkaz:
https://doaj.org/article/ea74787363804a54966b18653aaed881
Publikováno v:
Acta Medica, Vol 51, Iss 2, Pp 101-105 (2008)
One of perspective approaches in treatment of hematological malignancies is activation of death receptors for TRAIL. However, leukemia cells studied to date have shown variable susceptibility to TRAIL. Our study demonstrates that cells of acute T-lym
Externí odkaz:
https://doaj.org/article/c1866a8ebd1f451c918abf602ff482d6
Publikováno v:
Acta Medica, Vol 51, Iss 1, Pp 37-41 (2008)
Experiments presented here were aimed at the description of hematopoiesis repair and in vivo homing of transplanted separated CD117+B220– bone marrow cells after whole-body lethal irradiation at LD 9Gy. ROSA 26 mice were used as donors of marrow ce
Externí odkaz:
https://doaj.org/article/330c3aef0e274ed6823dedbffa46ad96
Autor:
Pavel Kuna, Milan Dostál, Otakar Neruda, Karel Volenec, Ivan Vodička, Leoš Navrátil, Pavel Petýrek, Václav Svoboda, Jan Šimša, Jiřina Vávrová
Publikováno v:
Acta Medica, Vol 47, Iss 1, Pp 19-22 (2004)
Summary: Sulphur containing radioprotective drugs amifostine (gammaphos, WR-2721) or cystamine (disulfide of meracaptoethylamine) of Czechoslovak production were examined in whole body fission neutrons irradiated rats in the thermal column of reactor
Externí odkaz:
https://doaj.org/article/8f5cf9dc1fa740fe8cee7704ef88cb0c
Autor:
Jan Österreicher, Michal Králik, Leoš Navrátil, Jiřina Vávrová, Jiří Škopek, Jiří Knížek, Aleš Macela
Publikováno v:
Acta Medica, Vol 44, Iss 4, Pp 125-130 (2001)
We measured number of bcl-2, apoptotic, neutrophil, and surfactant apoprotein D (SP-D) positive cells in irradiated rat lungs during different time points after the sublethal whole-thorax irradiation of rats. We also investigated the influence of pen
Externí odkaz:
https://doaj.org/article/018c0303065e4cf1bcf72488846854d4
Autor:
Jan Österreicher, Jaroslav Mokrý, Leoš Navrátil, Jiří Knížek, Jiřina Vávrová, Jiří Škopek, Aleš Macela
Publikováno v:
Acta Medica, Vol 44, Iss 1, Pp 15-19 (2001)
Purpose: We studied the relationship between type II pneumocytes number and alveolar septal thickness during different time after sublethal whole-thorax irradiation of rats and we investigated the influence of pentoxifylline (TNF-α inhibitor). Mater
Externí odkaz:
https://doaj.org/article/900125a94f08423085acad099674eac3
Publikováno v:
Acta Medica, Vol 44, Iss 1, Pp 7-13 (2001)
Cultivation with 4-8 μmol/l hypericin (specific proteinkinase C inhibitor) activated by light induced high inhibition of the rate of HL-60 cell growth. When hypericin treated cells were not exposed to light growth inhibition was insignificant. Culti
Externí odkaz:
https://doaj.org/article/7803a048a6764bd4bfca360203059379