Výsledky vyhledávání - "Jiří Schlanger"

Open-ring models of hetero-cannabinoids: Synthesis of 2-(alkylthio)-5-(2-aminoethyl)hydroquinone derivatives

Autor: M. Hrubantova, Martin Valchář, Antonín Dlabač, Emil Svátek, Karel Šindelář, Miroslav Protiva, Jiří Schlanger, Jiří Holubek

Publikováno v: Collection of Czechoslovak Chemical Communications. 55:782-796

2,5-Dimethoxythiophenol was S-alkylated with pentyl bromide and heptyl bromide, the sulfides IVa,b were chloromethylated and the products were transformed to the nitriles VIIa,b. Reduction with aluminium hydride gave the amines XIIIa,b which were tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12ceeaa7c0dcb4ebf88fa357df2a6cc6
https://doi.org/10.1135/cccc19900782

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ChemInform Abstract: Open-Ring Models of Hetero-Cannabinoids: Synthesis of 2-(Alkylthio)-5-(2-aminoethyl)hydroquinone Derivatives

Autor: Emil Svátek, M. Valchar, Jiří Holubek, Antonín Dlabač, Jiří Schlanger, M. Hrubantova, Miroslav Protiva, K. Sindelar

Publikováno v: ChemInform. 21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19836665fb3d9f6320788ef25bc131b6
https://doi.org/10.1002/chin.199028307

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Synthesis of spiro(piperidine-4,6'-dibenz[b,e]-1,4-oxathiepin) and its 1-methyl derivative as potential antidepressant agents

Autor: Martin Valchář, Miroslav Protiva, Antonín Dlabač, Jiří Schlanger, Karel Šindelář, Jiří Holubek

Publikováno v: Collection of Czechoslovak Chemical Communications. 50:503-509

Starting from 2-chloronitrobenzene and 2-fluorothiophenol, the synthesis of 2-bromo-2'-fluorodiphenyl sulfide (X) was carried out in three steps. The product was converted to the Grignard reagent which reacted with 1-ethoxycarbonyl-4-piperidone and g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f268a5001075b7bed5c9153661819998
https://doi.org/10.1135/cccc19850503

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Potential antipsychotic agents: 2-Chloro- and 2-methyl-11-(2-piperazinoethoxy)-6,11-dihydrodibenzo[b,e]thiepins and some related compounds; Synthesis and pharmacology

Autor: Emil Svátek, Jiří Schlanger, Jiřina Metyšová, V. Bartl, Jiří Holubek, Miroslav Protiva, Karel Šindelář, Vladimír Valenta, Antonín Dlabač

Publikováno v: Collection of Czechoslovak Chemical Communications. 49:2520-2530

Reactions of 2-chloro- and 2-methyl-6,11-dihydrodibenzo[b,e]thiepin-11-ol with 2-bromoethanol in the presence of sulfuric acid in boiling benzene afforded the 2-bromoethyl ethers VIa and VIb which were transformed by substitution reactions with 1-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3726cfd5d67dac2a4a572aa12ff6f16
https://doi.org/10.1135/cccc19842520

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Oxidative transformations of some pyrimidine derivatives into oxazolidine derivatives

Autor: Jiří Körbl, Jiří Schlanger, F. Jancik, Rudolf Kotva, Vladimír Pouzar, Jiří Holubek, Jiří Křepelka

Publikováno v: Collection of Czechoslovak Chemical Communications. 48:1212-1223

The action of dilute hydrogen peroxide in aqueous alkaline solutions on compounds I-VI and XX produced derivatives of 2-iminooxazolidine-4-one, VII-XI and XXI. Their structures were demonstrated by spectral comparison with hydantoin derivatives XXII,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93ba769257cbcda61a01e37811dcf867
https://doi.org/10.1135/cccc19831212

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Highly polar potential metabolites of the neuroleptic agent oxyprothepin: Synthesis of 2-hydroxy-8-methylsulfonyl and 3-hydroxy-8-methylsulfonyl derivatives of 10-[4-(3-hydroxypropyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin

Autor: Emil Svátek, Jiří Schlanger, Miroslav Protiva, Jiří Holubek, Josef Pomykáček, Jiří Jílek

Publikováno v: Collection of Czechoslovak Chemical Communications. 50:519-537

The acid XI, obtained by reaction of (2-iodo-5-methoxyphenyl)acetic acid with 4-(methylsulfonyl)thiophenol (VIII) in dimethylformamide in the presence of potassium carbonate and copper, was transformed via intermediates XIIa-XIVa to compound XVa. Dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::456c0f7db8766a176ff81f294ae291df
https://doi.org/10.1135/cccc19850519

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Synthesis of arylacetic acids and their effect on activation of fibrinolysis. Quantitative relations between structure and biological activity

Autor: Miroslav Kuchař, Zdeněk Roubal, O. Němeček, Jiří Schlanger, Bohumila Brunova

Publikováno v: Collection of Czechoslovak Chemical Communications. 45:1401-1409

A series of arylacetic acids, III, has been prepared and evaluated for activation of fibrinolysis and inhibition of heat-denaturation of serum albumin. regression analysis revealed that either activity was influenced mainly by lipophilicity of the ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7afb29b8e4a45ca54ff714bead07b588
https://doi.org/10.1135/cccc19801401

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Reactions of 11-chloro-11-phenyl-6,11-dihydrodibenzo[b,e]-thiepin with piperidine and some further nucleophiles

Autor: Miroslav Ryska, Vladimír Valenta, Jiří Holubek, Jiří Schlanger, Miroslav Protiva, Karel Šindelář, Jiří Urban, Emil Svátek, M. Hrubantova

Publikováno v: Collection of Czechoslovak Chemical Communications. 47:3094-3113

The title compound Vb affords with piperidine normal nucleophilic substitution product and the isomeric 3-piperidino derivative XXXII. The structure of XXXII was proven by (1) the 1H NMR and 13C NMR spectra, (2) an independent synthesis via the inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36fb2175167d05d8597b40b294d6cc5d
https://doi.org/10.1135/cccc19823094

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