Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jiří Nehyba"'
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86990 (2014)
The human TERT (hTERT) gene encodes the telomerase catalytic subunit which plays a role in telomerase regulation. Telomerase is activated in more than 90% of all human malignancies and understanding how telomerase is regulated is necessary for implem
Externí odkaz:
https://doaj.org/article/2355aa4184a247118b19fb3c942b756c
Publikováno v:
Molecular and Cellular Biology. 32:4283-4296
Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in-frame deletion which removed exons 4 through 13, encoding the cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b8226cf16449f2cdb4803edadb60c9
https://doi.org/10.1128/mcb.00550-12
https://doi.org/10.1128/mcb.00550-12
Publikováno v:
Molecular and Cellular Biology. 29:929-941
Telomerase activity is downregulated in somatic cells but is upregulated during the activation of cells of the immune system. The mechanism of this reactivation is not well understood. In this study, we demonstrated that interferon regulatory factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acb21bf142c5658bfbd7e3fcbf608a8
https://doi.org/10.1128/mcb.00961-08
https://doi.org/10.1128/mcb.00961-08
Publikováno v:
Molecular and Cellular Biology. 21:6369-6386
v-rel, which is derived from the c-rel proto-oncogene, is the acutely transforming oncogenic member of the Rel/NF-κB family (32, 42). The Rel/NF-κB family of transcription factors regulate gene expression from promoters or enhancers containing κB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db73245da536328dec00124474d53f8d
https://doi.org/10.1128/mcb.21.19.6369-6386.2001
https://doi.org/10.1128/mcb.21.19.6369-6386.2001
Publikováno v:
eLS
The interferon regulatory factors (IRFs) are a family of transcription factors that play central roles in immune defence and stress responses. All IRF proteins share a deoxyribonucleic acid (DNA)-binding domain. IRF genes first appeared in the last c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8cf3541d5155f3b1761841be6f88b1b
https://doi.org/10.1002/9780470015902.a0022874
https://doi.org/10.1002/9780470015902.a0022874
This manuscript presents the first extensive phylogenetics analysis of a key family of immune regulators, the interferon regulatory factor (IRF) family. The IRF family encodes transcription factors that play important roles in immune defense, stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2285fb432bfa2d6716f7f04e965b5b
https://europepmc.org/articles/PMC2767096/
https://europepmc.org/articles/PMC2767096/
Publikováno v:
Journal of virology. 80(1)
Telomerase is activated during the transformation of lymphoid cells and fibroblasts by v-Rel, the oncogenic member of the Rel/NF-κB family of transcription factors. v-Rel-transformed cell lines have longer telomeres than untransformed chicken lympho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d1266ecb2ce04f9c786a5f32201b18
https://pubmed.ncbi.nlm.nih.gov/16352553
https://pubmed.ncbi.nlm.nih.gov/16352553
The cloning and functional characterization of a novel interferon regulatory factor (IRF), IRF-10, are described. IRF-10 is most closely related to IRF-4 but differs in both its constitutive and inducible expression. The expression of IRF-10 is induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056ad3de0981826c3d23815364c22b31
https://europepmc.org/articles/PMC133824/
https://europepmc.org/articles/PMC133824/
Publikováno v:
Journal of virology. 69(6)
The c-rel proto-oncogene encodes a member of the Rel/NF-kappa B family of transcription factors. The oncogenic viral form, v-rel, transduced by avian reticuloendotheliosis virus T, induces lymphoid tumors. v-Rel transformation may be mediated directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a03d5d7d11bcbe935ce9ab8dda79a16
https://pubmed.ncbi.nlm.nih.gov/7745683
https://pubmed.ncbi.nlm.nih.gov/7745683
Publikováno v:
Journal of virology. 69(1)
The v-Rel oncogene induces the expression of major histocompatibility complex class I and II proteins and the interleukin-2 receptor more efficiently than does c-Rel (R. Hrdlicková, J. Nehyba, and E. H. Humphries, J. Virol. 68:308-319, 1994). The ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650a09402b91c18292aebbec69e3b13f
https://pubmed.ncbi.nlm.nih.gov/7983736
https://pubmed.ncbi.nlm.nih.gov/7983736