Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Jiří, Zahradník"'
Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Autor:
Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe, Shayne F. Andrew, Samantha J. Provost, Lauren McCormick, Alex Van Ry, Elizabeth McCarthy, John-Paul M. Todd, Saran Bao, I-Ting Teng, Shir Marciano, Yinon Rudich, Chunlin Li, Shilpi Jain, Bushra Wali, Laurent Pessaint, Alan Dodson, Anthony Cook, Mark G. Lewis, Hanne Andersen, Jiří Zahradník, Mehul S. Suthar, Martha C. Nason, Kathryn E. Foulds, Peter D. Kwong, Mario Roederer, Gideon Schreiber, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the vir
Externí odkaz:
https://doaj.org/article/398a2dfd9ac6483f881f1a81f6f17840
Publikováno v:
Communications Earth & Environment, Vol 4, Iss 1, Pp 1-14 (2023)
Abstract Damages due to large earthquakes are influenced by broadband source effects that remain enigmatic. Here we develop a broadband (0–10 Hz) source model of the disastrous 2023 Mw7.8 Kahramanmaraş, Türkiye, earthquake by modeling recordings
Externí odkaz:
https://doaj.org/article/d9a569d6177f416787374cb8718876eb
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Human interleukin 24 (IL-24) is a multifunctional cytokine that represents an important target for autoimmune diseases and cancer. Since the biological functions of IL-24 depend on interactions with membrane receptors, on-demand regulation of the aff
Externí odkaz:
https://doaj.org/article/21bd92ed5a464deea6ac520a115d5633
Autor:
Esteban Poveda, Patricia Pedraza, Francisco Velandia, Edwin Mayorga, Vladimír Plicka, František Gallovič, Jiří Zahradník
Publikováno v:
Earth and Space Science, Vol 9, Iss 12, Pp n/a-n/a (2022)
Abstract The boundary between the Northern Andean block and the South American plate is a first‐order tectonic structure in Colombia with historically M > 7 earthquakes. However, details about individual sections of the system remain unknown. We il
Externí odkaz:
https://doaj.org/article/0c904f07f46a41c88f89d7ff27c06484
Geodynamic subduction models constrained by deep earthquakes beneath the Japan Sea and eastern China
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Details of Pacific plate subduction under the Japan Sea and associated current seismicity remain challenging. Seismic tomography reveals a continuous slab dipping at ~30° down to ~600 km, and earthquake mechanisms point to down-dip compress
Externí odkaz:
https://doaj.org/article/f9120078c2dd4de5b63d95dcee8c176d
Autor:
Junqing Liu, Jiří Zahradník
Publikováno v:
Geophysical Research Letters, Vol 47, Iss 4, Pp n/a-n/a (2020)
Abstract The increased seismic activity of the last ~10 years in Changning county of Sichuan Province comprised just small (mostly ML < 5.0) injection‐induced earthquakes. The MW 5.7 earthquake on June 17, 2019, is the largest event ever reported t
Externí odkaz:
https://doaj.org/article/ecef393b6ee74d0ba6121ed6d7768994
Autor:
Michal Grulich, Bartlomiej Surpeta, Andrea Palyzová, Helena Marešová, Jiří Zahradník, Jan Brezovsky
The rapid increase in antibiotic-resistant bacteria and the inability to provide new generations of potent antimicrobials necessitates the search for new, unconventional solutions. Methods based on targeting bacterial communication induced by signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8afb5df1150f0f36f5609505d1c37c1
https://doi.org/10.1101/2023.05.09.538545
https://doi.org/10.1101/2023.05.09.538545
Autor:
Phuong Ngoc Pham, Maroš Huličiak, Lada Biedermannová, Jiří Černý, Tatsiana Charnavets, Gustavo Fuertes, Štěpán Herynek, Lucie Kolářová, Petr Kolenko, Jiří Pavlíček, Jiří Zahradník, Pavel Mikulecky, Bohdan Schneider
Publikováno v:
Viruses, Vol 13, Iss 2, p 190 (2021)
Engineered small non-antibody protein scaffolds are a promising alternative to antibodies and are especially attractive for use in protein therapeutics and diagnostics. The advantages include smaller size and a more robust, single-domain structural f
Externí odkaz:
https://doaj.org/article/ca7c6b6725114b919d25f73d80bebe28
Key to studies of the rupture process is the identification of its major segmentation into asperities. Common multi-parametric methods invert for a continuous slip distribution; they usually rely on a predefined fault position, nucleation point, plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a409c59b592598dcd520ae047a02355
https://doi.org/10.31223/x5t666
https://doi.org/10.31223/x5t666
Autor:
Jiří Zahradník, Petr Kolenko, Andrea Palyzová, Jiří Černý, Lucie Kolářová, Eva Kyslíková, Helena Marešová, Michal Grulich, Jaroslav Nunvar, Miroslav Šulc, Pavel Kyslík, Bohdan Schneider
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195299 (2018)
Old Yellow Enzymes (OYEs) are NAD(P)H dehydrogenases of not fully resolved physiological roles that are widespread among bacteria, plants, and fungi and have a great potential for biotechnological applications. We determined the apo form crystal stru
Externí odkaz:
https://doaj.org/article/5865c5a8fc61418589ff1f019fecd309