Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jiří, Jiráček"'
Autor:
Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 profor
Externí odkaz:
https://doaj.org/article/a75353d92d0a4e7788613a21e0db85e9
Autor:
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101863- (2024)
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study
Externí odkaz:
https://doaj.org/article/7c5f60a2f83f44fdb26861620a039b02
Autor:
Anna Kertisová, Lenka Žáková, Kateřina Macháčková, Aleš Marek, Pavel Šácha, Petr Pompach, Jiří Jiráček, Irena Selicharová
Publikováno v:
Open Biology, Vol 13, Iss 11 (2023)
The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors. Recently, the portfolio of solved hormone–receptor structures has grown extensively thanks to a
Externí odkaz:
https://doaj.org/article/85854c8c7ff941429cf6951fa7321724
Autor:
Seiya Asai, Jana Moravcová, Lenka Žáková, Irena Selicharová, Romana Hadravová, Andrzej Marek Brzozowski, Jiří Nováček, Jiří Jiráček
Publikováno v:
Open Biology, Vol 12, Iss 12 (2022)
Insulin is stored in vivo inside the pancreatic β-cell insulin secretory granules. In vitro studies have led to an assumption that high insulin and Zn2+ concentrations inside the pancreatic β-cell insulin secretory granules should promote insulin c
Externí odkaz:
https://doaj.org/article/8d20a960503a46be96447133ee95a8b1
Autor:
Martina Chrudinová, François Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiří Jiráček, C. Ronald Kahn, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101121- (2021)
Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to hu
Externí odkaz:
https://doaj.org/article/6021b0b3fea045b7b555497608ce50e0
Autor:
Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are no
Externí odkaz:
https://doaj.org/article/cd3027437e574e159af8775f069f9003
Autor:
Pavlo Potalitsyn, Irena Selicharová, Kryštof Sršeň, Jelena Radosavljević, Aleš Marek, Kateřina Nováková, Jiří Jiráček, Lenka Žáková
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238393 (2020)
Insulin-like growth factors 2 and 1 (IGF2 and IGF1) and insulin are closely related hormones that are responsible for the regulation of metabolic homeostasis, development and growth of the organism. Physiological functions of insulin and IGF1 are rel
Externí odkaz:
https://doaj.org/article/c359dec76f9a4f9fbf78b085bba5e792
Publikováno v:
Molecules, Vol 26, Iss 18, p 5636 (2021)
The problem of a growing resistance of bacteria and other microorganisms to conventional antibiotics gave rise to a search for new potent antimicrobial agents. Insect antimicrobial peptides (AMPs) seem to be promising novel potential anti-infective t
Externí odkaz:
https://doaj.org/article/7164fecd198b420484e7480260637910
Autor:
Petr Pompach, Cristina M. Viola, Jelena Radosavljević, Jingjing Lin, Jiří Jiráček, Andrzej M. Brzozowski, Irena Selicharová
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Structural details of changes accompanying interaction between insulin-related hormones and their binding partners are often enigmatic. Here, cross-linking/mass spectrometry could complement structural techniques and reveal details of these protein-p
Externí odkaz:
https://doaj.org/article/4bd794a741d7415cb3a66a17b4584e79
Autor:
Jiří Jiráček, Lenka Žáková
Publikováno v:
eLife, Vol 8 (2019)
Cone snails have evolved a variety of insulin-like molecules that may help with the development of better treatments for diabetes.
Externí odkaz:
https://doaj.org/article/c109d9ca296d4bc4a5c52b61c68fbf68