Výsledky vyhledávání - "Ji, Yue Jeff Zhang"

Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment

Autor: Ji Yue Jeff Zhang, Jiang Wei Zhang, Yi Jin, Counde Oyang, C. Zhang, Markus Walles, Lijun Zhang, Joachim Blanz, Jerôme Dayer, Michael Kiffe, Ying Huang, Arevalo Sanchez

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 52(1)

1. MAK683 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine) is a potent and orally bioavailable EED inhibitor for the potential treatment in oncology. Pharmacokinetics (PK) in preclinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9722094e59dabab5ac1a99b6b8357560
https://pubmed.ncbi.nlm.nih.gov/34761729

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Gender differences pharmacokinetics, bioavailability, hepatic metabolism and metabolism studies of Pinnatifolone A, a sesquiterpenoid compound, in rats by LC-MS/MS and UHPLC-Q-TOF-MS/MS

Autor: Wanqian, Peng, Zhiqiang, Li, Dingji, Cai, Xiaocui, Yi, Ji, Yue Jeff Zhang, Guoyue, Zhong, Hui, Ouyang, Yulin, Feng, Shilin, Yang

Publikováno v: Phytomedicine. 109:154544

Pinnatifolone A is a typical sesquiterpenoid and the primary active ingredient of Syringa oblata Lindl., has potent anti-inflammatory activity. However, Pinnatifolone A pharmacokinetic and metabolites analysis investigations in male and female rats,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019a41038590eed3aaf3521d2117ca2a
https://doi.org/10.1016/j.phymed.2022.154544

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In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401

Autor: Qian Li, Chun Ye Zhang, Yao Chang Xu, Jing Quan Dai, Sylvia Zhao, Jiang Wei Zhang, Feng He, Ji Yue Jeff Zhang, Hui Xin Wan, Hai Bing Deng, Hong Ping Yu, Qian Gang Zheng

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 44:669-680

MET401 is a potent and selective c-Met inhibitor with a novel triazolopyrimidine scaffold. The aim of this study was to determine the pharmacokinetic profile of MET401 in preclinical species, and to identify the metabolic soft spot and enzyme involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6419719abab5c179958c0e4c47f08e4
https://doi.org/10.1007/s13318-019-00557-9

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Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect

Autor: Wen Xiao, Jiang Wei Zhang, Ji Yue Jeff Zhang, Zhen Ting Gao, Zheng Tian Yu

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(12)

Some quinoline-containing c-Met kinase inhibitors are aldehyde oxidase (AO) substrates. 3-Substituted quinoline triazolopyridine analogs were synthesized to understand the electron-donating and steric hindrance effects on AO-mediated metabolism. Meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e01528e5d4772c201afa72ad2ed088
https://pubmed.ncbi.nlm.nih.gov/30209037

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