Výsledky vyhledávání - "Jhung W. Jhung"

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

Autor: Brent H. Cochran, Amy Simon, Powen Tu, Deepa Bhavsar, Mariano Severgnini, Satoe Takahashi, Robert J. Homer, George Perides, Jhung W. Jhung

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 171:858-867

The cascade of cellular and molecular pathways mediating acute lung injury is complex and incompletely defined. Although the Src and Jak family of kinases is upregulated in LPS-induced murine lung injury, their role in the development of lung injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6717a2197427df66a5cf76bd50362e
https://doi.org/10.1164/rccm.200407-981oc

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Activation of the STAT pathway in acute lung injury

Autor: George Perides, Paul M. Hassoun, Michael L. Steer, Amy Simon, Satoe Takahashi, Brent H. Cochran, Liliana M. Rozo, Jhung W. Jhung, Charles Kuhn, Barry L. Fanburg, Mariano Severgnini, Robert J. Homer

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L1282-L1292

Acute lung injury (ALI) is a devastating clinical problem with a mortality as high as 60%. It is now appreciated that ALI represents a cytokine excess state that involves the microvasculature of multiple organs. The signal transducers and activators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ac1122b4aa2053bf4e43fa38436fd6
https://doi.org/10.1152/ajplung.00349.2003

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Additive Effects of Human Recombinant Interleukin-11 and Granulocyte Colony-Stimulating Factor in Experimental Gram-Negative Sepsis

Autor: Samuel J. Goldman, John E. Palardy, Steven M. Opal, Jhung W. Jhung, James C. Keith, Nicolas A. Parejo

Publikováno v: Blood. 93:3467-3472

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used to promote granulocyte recovery from a variety of pathologic states. Recombinant human interleukin-11 (rhIL-11) has recently become available clinically as a platelet re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b79df8f0b8c35283fccdbf9852d7102
https://doi.org/10.1182/blood.v93.10.3467.410k10_3467_3472

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Potentia Hazards of Combination Immunotherapy in the Treatment of Experimental Septic Shock

Autor: John E. Palardy, Jhung W. Jhung, Lynnette D. Young, Nicholas A. Parejo, Alan S. Cross, Steven M. Opal, Curtis Donsky

Publikováno v: Journal of Infectious Diseases. 173:1415-1421

Using an actual infection model of Pseudomonas aeruginosa sepsis in neutropenic rats, the potential utility of a combination anticytokine approach for the treatment of sepsis was tested. A dimeric tumor necrosis factor binding protein (TNF-BP) consis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4865d56a412e8db5cd7e4339e7df9276
https://doi.org/10.1093/infdis/173.6.1415

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WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock

Autor: Nicolas A. Parejo, John E. Palardy, Jhung W. Jhung, Patricia Cristofaro, Steven M. Opal, Heather A. Harris, James C. Keith

Publikováno v: Critical care medicine. 34(8)

To determine the effect of an estrogen receptor-beta selective agent in experimental models of systemic infection and sepsis.WAY-202196, a nonsteroidal selective estrogen receptor-beta agonist, was tested in the murine listeriosis model, the neutrope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9b61cbb90c128f5338c6590ab5dc6d
https://pubmed.ncbi.nlm.nih.gov/16755255

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The activity of pathway-selective estrogen receptor ligands in experimental septic shock

Autor: Steven M. Opal, Robert John Steffan, James C. Keith, John E. Palardy, Jhung W. Jhung, Nicolas A. Parejo, Thomas J. Caggiano, Sue Chippari, Christopher C. Chadwick, Patricia Cristofaro, Douglas C Harnish

Publikováno v: Shock (Augusta, Ga.). 24(6)

Estrogen receptors (ER) are widely expressed in multiple genital and nongenital tissues. Upon engagement of these receptors, multiple genes are affected in target tissues via estrogen response elements. Nonsteroidal pathway-selective ER ligands have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4866dafda2165d0f38a0bbdaf34f5d7
https://pubmed.ncbi.nlm.nih.gov/16317384

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Chloroquine enhances survival in Bacillus anthracis intoxication

Autor: Michael D. Green, Steven M. Opal, Andrew W. Artenstein, Patricia Cristofaro, Jhung W. Jhung, Nicolas A. Parejo, John E. Palardy

Publikováno v: The Journal of infectious diseases. 190(9)

The intentional release of anthrax in the United States in 2001 resulted in 11 cases of inhalational disease, with an attendant mortality rate of 45%. Current therapeutic options for anthrax are limited; antimicrobials target only replicating organis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff74e4abbd62ed1a8516eeb39cf51a3e
https://pubmed.ncbi.nlm.nih.gov/15478072

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Orally administered recombinant human interleukin-11 is protective in experimental neutropenic sepsis

Autor: John E. Palardy, James C. Keith, Nicolas A. Parejo, Steven M. Opal, Jhung W. Jhung, Vasu Maganti, Erik Marchese

Publikováno v: The Journal of infectious diseases. 187(1)

Recombinant human interleukin (IL)-11 is a multifunctional cytokine with hematopoietic, immunomodulatory, and epithelial cell protective activities. IL-11alpha receptors are expressed on the luminal surface of intestinal epithelial cells. It was hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d8dc4dc431ec423dccf09179aaac40
https://pubmed.ncbi.nlm.nih.gov/12508148

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