Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jhumku D. Kohtz"'
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191794 (2018)
Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy. GAD65-/- (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation. One fifth of GAD65
Externí odkaz:
https://doaj.org/article/5f56f748a1524bb8af8298d2b44ca85b
Autor:
Kelsey R. Swyter, Ferhat Ay, Hao Luo, Ivelisse Cajigas, Linden Collens, Abhijit Chakraborty, Monique Bastidas, Madison Lynam, Jhumku D. Kohtz
Publikováno v:
Development
The Evf2 long non-coding RNA directs Dlx5/6 ultraconserved enhancer(UCE)-intrachromosomal interactions, regulating genes across a 27 Mb region on chromosome 6 in mouse developing forebrain. Here, we show that Evf2 long-range gene repression occurs th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c8e34fd24a6bd0edd12de0a6e946fa
https://europepmc.org/articles/PMC7990859/
https://europepmc.org/articles/PMC7990859/
Autor:
Jhumku D. Kohtz, Kelsey R. Swyter, Ferhat Ay, Ivelisse Cajigas, Hao Luo, Madison Lynam, Linden Collens, Abhijit Chakraborty, Monique Bastidas
SummaryPrecise regulation of gene expression networks requires the selective targeting of DNA enhancers. The Evf2 long non-coding RNA regulates Dlx5/6 ultraconserved enhancer(UCE) interactions with long-range target genes, controlling gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6475eda624b96857b9136e25e4b8b8a3
https://doi.org/10.1101/2020.09.22.307215
https://doi.org/10.1101/2020.09.22.307215
Autor:
Chunming Bi, Jhumku D. Kohtz, Diana S. Himmelstein, Grant Van Der Voort, Ivelisse Cajigas, Brian S. Clark
Publikováno v:
Developmental Biology. 424:221-235
Sonic hedgehog (SHH) is a master developmental regulator. In 1995, the SHH crystal structure predicted that SHH-E176 (human)/E177 (mouse) regulates signaling through a Zn2+-dependent mechanism. While Zn2+ is known to be required for SHH protein stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532933c70a786553a9896d6e480c9b4e
https://doi.org/10.1016/j.ydbio.2017.02.006
https://doi.org/10.1016/j.ydbio.2017.02.006
Autor:
Sara J. Kohtz, Abhijit Chakraborty, Ivelisse Cajigas, Monique Bastidas, Kelsey S. Swyter, Jhumku D. Kohtz, Ferhat Ay
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4c0a90d1e32aa5256990e675efad59
https://doi.org/10.1096/fasebj.2018.32.1_supplement.525.19
https://doi.org/10.1096/fasebj.2018.32.1_supplement.525.19
Autor:
Rolf O. Karlstrom, Jhumku D. Kohtz, Marcey Osgood, A. Tuba Ozacar, Jochebed Pink, Crina Boeras, Jeanne E. Thomas, Meng Chieh Shen
Publikováno v:
Developmental Dynamics. 242:539-549
Background: Hedgehog (Hh) signaling is required for embryogenesis and continues to play key roles postembryonically in many tissues, influencing growth, stem cell proliferation, and tumorigenesis. Systems for conditional regulation of Hh signaling fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c36ab2a599d9d5bdf3d4beddb60f94
https://doi.org/10.1002/dvdy.23955
https://doi.org/10.1002/dvdy.23955
Autor:
Michael J.W. VanGompel, Elizabeth R. Morris, Sooky Koh, Sean Chen, Sara J. Kohtz, Jhumku D. Kohtz, Ivelisse Cajigas, Maximilliano Nigro, Marco Martina, Kelsey R. Swyter, David E. Leib, Hao Luo, Abhijit Chakraborty, Monique Bastidas, Ferhat Ay
Publikováno v:
Molecular Cell. 71:956-972.e9
Gene regulation requires selective targeting of DNA regulatory enhancers over megabase (Mb) distances. Here, we show that Evf2, a cloud-forming Dlx5/6 ultraconserved enhancer (UCE) lncRNA simultaneously localizes to activated (Umad1, 1.6Mb distant) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7425d7359b971a68a69ca2180defb5a
https://doi.org/10.1016/j.molcel.2018.07.024
https://doi.org/10.1016/j.molcel.2018.07.024
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0191794 (2018)
PLoS ONE, Vol 13, Iss 1, p e0191794 (2018)
Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy. GAD65-/- (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation. One fifth of GAD65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d55b7e04e4c874c38f009e7a651e71
https://doi.org/10.1371/journal.pone.0191794
https://doi.org/10.1371/journal.pone.0191794
Autor:
Michael J.W. VanGompel, Allison M. Bond, John F. Disterhoft, Jhumku D. Kohtz, Mary F. Clark, Evgeny A. Sametsky, Julie C. Savage
Publikováno v:
Nature neuroscience
Summary Genomic studies demonstrate that while the majority of the mammalian genome is transcribed, only about 2% of these transcripts are protein coding. We have been investigating how the long, polyadenylated Evf2 non-coding RNA regulates transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b754edd356f3fc5c1e79f083f636d28
https://doi.org/10.1038/nn.2371
https://doi.org/10.1038/nn.2371
Autor:
Ivelisse, Cajigas, David E, Leib, Jesse, Cochrane, Hao, Luo, Kelsey R, Swyter, Sean, Chen, Brian S, Clark, James, Thompson, John R, Yates, Robert E, Kingston, Jhumku D, Kohtz
Publikováno v:
Development (Cambridge, England). 142(15)
Transcription-regulating long non-coding RNAs (lncRNAs) have the potential to control the site-specific expression of thousands of target genes. Previously, we showed that Evf2, the first described ultraconserved lncRNA, increases the association of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::632bd0b92258fa8a44b306ee38abb100
https://pubmed.ncbi.nlm.nih.gov/26138476
https://pubmed.ncbi.nlm.nih.gov/26138476