O13.4 Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier

Autor: Raju Gautam, Jonathan M. Wastling, Gilles Ndayisaba, Hanneke Borgdorff, N H van Teijlingen, Jhhm van de Wijgert, Dong Xia, Tbh Geijtenbeek, Stuart D. Armstrong

Publikováno v: Sexually Transmitted Infections. 91:A54.1-A54

Introduction Vaginal microbiome (VMB) dysbiosis is associated with increased acquisition of HIV and sexually transmitted infections (STIs). Cervicovaginal inflammation and other changes to the mucosal barrier are thought to play important roles but h

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https://doi.org/10.1136/sextrans-2015-052270.150

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Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells.

Autor: van Teijlingen NH; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands.; Department of Obstetrics and Gynecology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., van Smoorenburg MY; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands., Sarrami-Forooshani R; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Advanced Therapy Medicinal Product Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic center for Education, Culture and Research, Tehran, Iran., Zijlstra-Willems EM; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands., van Hamme JL; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands., Borgdorff H; Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., van de Wijgert JHHM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Leeuwen E; Department of Obstetrics and Gynecology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., van der Post JAM; Department of Obstetrics and Gynecology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Strijbis K; Department of Biomolecular Health Sciences, Division of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Ribeiro CMS; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands., Geijtenbeek TBH; Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Jul 25; Vol. 230 (1), pp. e43-e47.

Novel point-of-care cytokine biomarker lateral flow test for the screening for sexually transmitted infections and bacterial vaginosis: study protocol of a multicentre multidisciplinary prospective observational clinical study to evaluate the performance and feasibility of the Genital InFlammation Test (GIFT).

Autor: Ramboarina S; Institut Pasteur de Madagascar, Madagascar., Crucitti T; Institut Pasteur de Madagascar, Madagascar tcrucitti@pasteur.mg., Gill K; Desmond Tutu HIV Centre, University of Cape Town, South Africa., Bekker LG; Desmond Tutu HIV Centre, University of Cape Town, South Africa., Harding-Esch EM; London School of Hygiene & Tropical Medicine, England., van de Wijgert JHHM; Julius Center University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Huynh BT; Institut Pasteur, Université Paris Cité, France.; Université Paris-Saclay, Université Versailles Saint-Quentin, Inserm, France., Fortas C; Institut Pasteur, Université Paris Cité, France.; Université Paris-Saclay, Université Versailles Saint-Quentin, Inserm, France., Harimanana A; Institut Pasteur de Madagascar, Madagascar., Mayouya Gamana T; Institut Pasteur de Madagascar, Madagascar., Randremanana RV; Institut Pasteur de Madagascar, Madagascar., Mangahasimbola R; Institut Pasteur de Madagascar, Madagascar., Dziva Chikwari C; London School of Hygiene & Tropical Medicine, England.; Organization for Public Health Interventions and Development, Zimbabwe.; The Biomedical Research and Training Institute, Zimbabwe., Kranzer K; London School of Hygiene & Tropical Medicine, England.; Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Munich, Germany., Mackworth-Young CRS; London School of Hygiene & Tropical Medicine, England., Bernays S; London School of Hygiene & Tropical Medicine, England.; School of Public Health, University of Sydney, New South Wales, Australia., Thomas N; Desmond Tutu HIV Centre, University of Cape Town, South Africa., Anderson D; Disease Elimination Program, Life Sciences Discipline,Burnet Institute, Melbourne, Australia., Tanko FR; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.; The Medical Research Centre, Institute of Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon.; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, South Africa., Manhanzva M; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, South Africa., Lurie M; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, South Africa., Khumalo F; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, South Africa., Sinanovic E; Health Economics Unit, School of Public Health, Faculty of Health Sciences, University of Cape Town, South Africa., Honda A; Research Center for Health Policy and Economics, Hitotsubashi Institute for Advanced Study, Hitotsubashi University, Japan., Pidwell T; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa., Francis SC; London School of Hygiene & Tropical Medicine, England., Masson L; Disease Elimination Program, Life Sciences Discipline,Burnet Institute, Melbourne, Australia.; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, South Africa.; Central Clinical School, Monash University, Victoria, Australia.; National Health Laboratory Service, Cape Town, South Africa., Passmore JA; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, South Africa.; National Health Laboratory Service, Cape Town, South Africa.

Publikováno v: BMJ open [BMJ Open] 2024 May 01; Vol. 14 (5), pp. e084918. Date of Electronic Publication: 2024 May 01.

Within-episode repeat antibiotic prescriptions in patients with respiratory tract infections: A population-based cohort study.

Autor: Lalmohamed A; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. Electronic address: a.lalmohamed@umcutrecht.nl., Venekamp RP; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Bolhuis A; Department of Life Sciences and the Centre for Therapeutic Innovation, University of Bath, Bath, UK., Souverein PC; Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., van de Wijgert JHHM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Gulliford MC; King's College London, School of Life Course & Population Sciences, London, UK., Hay AD; Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.

Publikováno v: The Journal of infection [J Infect] 2024 Apr; Vol. 88 (4), pp. 106135. Date of Electronic Publication: 2024 Mar 08.