Preclinical evaluation of 'whole' cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes

Autor: Sa, Ali, Cs, Mclean, Mike Boursnell, Martin G, Cl, Holmes, Reeder S, Entwisle C, Dm, Blakeley, Jg, Shields, Todryk S, Vile R, Ra, Robins, Rc, Rees

Publikováno v: Europe PubMed Central

The development of genetically modified "whole" tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors. In the present study, we have used a disabled infectious single cycle-herpes simplex virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6176b09d279e08ced01b6468bcce6212
https://pubmed.ncbi.nlm.nih.gov/10749137

Disabled infectious single cycle (DISC) herpes simplex virus as a vector for immunotherapy of cancer

Autor: Mike Boursnell, Entwisle C, Sa, Ali, Sd, Sivasubramaniam, Reeder S, Cs, Mclean, Dm, Blakeley, Miller J, Hill S, Jg, Shields, Sc, Inglis, Rc, Rees

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d7863a66d2e6d4374f15525c58026f7b
http://europepmc.org/abstract/med/10026900

Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein.

Autor: Higgins LM; Department of Paediatric Gastroenterology, St. Bartholemew's and The Royal London School of Medicine and Dentistry, St. Bartholomew's Hospital, United Kingdom., McDonald SA, Whittle N, Crockett N, Shields JG, MacDonald TT

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1999 Jan 01; Vol. 162 (1), pp. 486-93.

Generation of a primary immune response to a genetically inactivated (DISC) herpes simplex virus and wild type virus.

Autor: Hill S; Cantab Pharmaceuticals Research Ltd, Cambridge, UK., Zhang X, Boursnell ME, Shields JG, Ricciardi-Castagnoli P, Hickling JK

Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 1997 May; Vol. 25 (2), pp. 200S.

CD19 regulation of human B cell responses. B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used.

Autor: Callard RE; Cellular Immunology Unit, Institute of Child Health, London, U.K., Rigley KP, Smith SH, Thurstan S, Shields JG

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1992 May 15; Vol. 148 (10), pp. 2983-7.