Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear

Autor: Mohammed Razeeth Shait Mohammed, Sandhya Krishnan, Rabbind Singh Amrathlal, Jeya Maheshwari Jayapal, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the

Externí odkaz: https://doaj.org/article/2e0e2f44373c47e398012dd938197421

Data set of Aspergillus flavus induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection

Autor: Jeyalakshmi Kandhavelu, Naveen Luke Demonte, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Chitra Thangavel, Jeya Maheshwari Jayapal, Dharmalingam Kuppamuthu

Publikováno v: Data in Brief, Vol 9, Iss C, Pp 888-894 (2016)

Fungal keratitis is one of the leading causes of blindness in the tropical countries affecting individuals in their most productive age. The host immune response during this infection is poorly understood. We carried out comparative tear proteome ana

Externí odkaz: https://doaj.org/article/cecd1e381a53487ab17bce246ea77341

Molecular Mimicry between Betaine Aldehyde Dehydrogenase of Leptospira and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients

Autor: Dharmalingam Kuppamuthu, Jeya Maheshwari Jayapal, Irene Daniel, Sivakumar R. Rathinam

Publikováno v: Ocular Immunology and Inflammation. 29:579-586

Purpose: Rapidly progressing cataract is one of the ocular manifestations in leptospiral uveitis patients. We examined whether molecular mimicry between the leptospira antigens and lens proteins exists that could result in cataract in these patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::368786b7f7bd5d51abd7c23185dd6d83
https://doi.org/10.1080/09273948.2019.1687732

Differential interactions of serum and bronchoalveolar lavage complement proteins with conidia of airborne fungal pathogen Aspergillus fumigatus

Autor: J. Iñaki Guijarro, Rajashri Shende, Jean-Pierre Gangneux, Taruna Madan, Prajna Lalitha, Sarah Dellière, Irene Daniel, Jagadeesh Bayry, Dharmalingam Kuppamuthu, Jeya Maheshwari Jayapal, Vishukumar Aimanianda, Sarah Sze Wah Wong, Hélène Guegan

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2020, 88 (9), ⟨10.1128/IAI.00212-20⟩
Infect Immun
Infection and Immunity, 2020, 88 (9), ⟨10.1128/IAI.00212-20⟩

Even though both cellular and humoral immunities contribute to host defense, the role played by humoral immunity against the airborne opportunistic fungal pathogen Aspergillus fumigatus has been underexplored. In this study, we aimed at deciphering t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834d7f30a907f0e25d9c0e56cb5f9055
https://hal.archives-ouvertes.fr/hal-02888806/document

Molecular Mimicry between Betaine Aldehyde Dehydrogenase of

Autor: Sivakumar, Rathinam, Irene, Daniel, Dharmalingam, Kuppamuthu, Jeya Maheshwari, Jayapal

Publikováno v: Ocular immunology and inflammation. 29(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fe46024bbac82475ac31a06106ee7f2
https://pubmed.ncbi.nlm.nih.gov/31746662