Zobrazeno 1 - 10 of 175 pro vyhledávání: '"Jeung Whan Han"'
1
Akademický článek
Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid
Autor: Jiye Jang, Hyewon Jung, Jaekyun Jeong, Junseok Jeon, Kyungho Lee, Hye Ryoun Jang, Jeung-Whan Han, Jaecheol Lee
Publikováno v: Heliyon, Vol 10, Iss 20, Pp e38714- (2024)
Heart organoid (HO) technology has successfully overcome the limitations of two-dimensional (2D) disease modeling and drug testing, thereby emerging as a valuable tool in drug discovery for assessing toxicity and efficacy. However, its ability to dis
Externí odkaz: https://doaj.org/article/8fac20a1d87d413fb8fb1e288ac1a3a6
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2
Akademický článek
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
Autor: Seoung Rak Lee, Bum Soo Lee, Jae Sik Yu, Heesun Kang, Min Jeong Yoo, Sang Ah Yi, Jeung-Whan Han, Sil Kim, Jung Kyu Kim, Jin-Chul Kim, Ki Hyun Kim
Publikováno v: Journal of Ginseng Research, Vol 46, Iss 3, Pp 357-366 (2022)
Background: Withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity. This study aims to identify the bioactive metabolites from Indian ginseng and
Externí odkaz: https://doaj.org/article/65b4f4cc76af4243afe709d923e4b1d6
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4
Akademický článek
Fermented ginseng extract, BST204, disturbs adipogenesis of mesenchymal stem cells through inhibition of S6 kinase 1 signaling
Autor: Sang Ah Yi, Jieun Lee, Sun Kyu Park, Jeom Yong Kim, Jong Woo Park, Min Gyu Lee, Ki Hong Nam, Jee Hun Park, Hwamok Oh, Saetbyul Kim, Jihoon Han, Bo Kyung Kim, Dong-Gyu Jo, Jeung-Whan Han
Publikováno v: Journal of Ginseng Research, Vol 44, Iss 1, Pp 58-66 (2020)
Background: The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identifie
Externí odkaz: https://doaj.org/article/45d4cdaeb80c4121a470736ef474c600
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5
Akademický článek
Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer
Autor: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee, Jeung-Whan Han
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a synergistic anti-tumo
Externí odkaz: https://doaj.org/article/bac10dabdb2243da8070712d388c21f5
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6
Akademický článek
Phytochemical Constituents Identified from the Aerial Parts of Lespedeza cuneata and Their Effects on Lipid Metabolism during Adipocyte Maturation
Autor: Heesun Kang, Min Jeong Yoo, Sang Ah Yi, Tae Wan Kim, Ji Won Ha, Myung Woo Na, Kun Hee Park, Seon-Hee Kim, Jeung-Whan Han, Tae Su Jang, Ki Hyun Kim
Publikováno v: Separations, Vol 8, Iss 11, p 203 (2021)
Lespedeza cuneata, belonging to Fabaceae, is well-known as Chinese bushclover, and it has been used in traditional folk medicines for the treatment of disorders, such as diabetes, hematuria, and insomnia. As part of continuing research projects to di
Externí odkaz: https://doaj.org/article/c95539f093654e3b9d643ac619cdfdfa
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7
Akademický článek
Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator
Autor: Sang Ah Yi, Ki Hong Nam, Min Gyu Lee, Hwamok Oh, Jae Sung Noh, Jae Kyun Jeong, Sangwoo Kwak, Ye Ji Jeon, So Hee Kwon, Jaecheol Lee, Jeung-Whan Han
Publikováno v: Molecules, Vol 26, Iss 18, p 5665 (2021)
Extensive epigenetic remodeling occurs during the cell fate determination of stem cells. Previously, we discovered that eudesmin regulates lineage commitment of mesenchymal stem cells through the inhibition of signaling molecules. However, the epigen
Externí odkaz: https://doaj.org/article/669ae273eb3249d6ad4e806967040cf7
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