Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jette Wypych"'
Autor:
Banghua Sun, Wei Fan, Aldona Balciunas, Jillian K. Cooper, Gal Bitan, Shirley Steavenson, Paul E. Denis, Yunjen Young, Beverly Adler, Larry Daugherty, Raffi Manoukian, Gary Elliott, Wenyan Shen, Jane Talvenheimo, David B. Teplow, Mitsuru Haniu, Raj Haldankar, Jette Wypych, Christopher A. Ross, Martin Citron, William G. Richards
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 1, Pp 111-122 (2002)
Amino-terminal fragments of huntingtin, which contain the expanded polyglutamine repeat, have been proposed to contribute to the pathology of Huntington's disease (HD). Data supporting this claim have been generated from patients with HD in which tru
Externí odkaz:
https://doaj.org/article/26fbad44ea784ee88e89c01dad9e7cb5
Autor:
Diandra Martinez-Cano, Rashmi Ravichandran, Huong Le, H. Edward Wong, Bharat Jagannathan, Erik J. Liu, William Bailey, Jane Yang, Kelli Matthies, Hedieh Barkhordarian, Bhavana Shah, Nithya Srinivasan, Jun Zhang, Angel Hsu, Jette Wypych, Jennitte Stevens, Deirdre Murphy Piedmonte, Les P. Miranda, Lauren Carter, Michael Murphy, Neil P. King, Neil Soice
Publikováno v:
Process Biochemistry. 129:241-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdb05762cb3b98d4e5226e4599710f5
https://doi.org/10.1016/j.procbio.2023.03.014
https://doi.org/10.1016/j.procbio.2023.03.014
Autor:
Yasser Nashed-Samuel, Jeremy Gastwirt, Ruchi B. Kotia, Stephanie Moore, Peter Masatani, Gianpiero Torraca, Monica Goss, David G. Dolan, Michael Akers, Chakradhar Padala, Jette Wypych, David J. Semin
Publikováno v:
Journal of Pharmaceutical Sciences. 111:3275-3286
A new type of lamellae-like particles was observed in protein based liquid therapeutic protein drug product (DP) packaged in standard (STD) and delamination controlled (DC) Type IB glass vials stored at 2-8°C as early as two weeks after manufacture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73451c5e94852aa5c82b3eca3191a026
https://doi.org/10.1016/j.xphs.2022.09.005
https://doi.org/10.1016/j.xphs.2022.09.005
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60eec5c9e91d5e594db47c591d04512b
https://doi.org/10.1016/j.xphs.2023.05.005
https://doi.org/10.1016/j.xphs.2023.05.005
Autor:
Bhavana Shah, Michael Ronk, Jian Liu, Kim Li, Yasser Nashed-Samuel, Zhongqi Zhang, Jason Richardson, Jette Wypych, Yanxin Luo, David J. Semin, Joel Perez-Pacheco, Ellen Jin
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3794-3802
Battery-powered drug delivery devices are widely used as primary containers for storing and delivering therapeutic protein products to improve patient compliance and quality of life. Compared to conventional delivery approaches such as pre-filled syr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7278cb1f03ee86004818109951f61877
https://doi.org/10.1016/j.xphs.2021.08.007
https://doi.org/10.1016/j.xphs.2021.08.007
Publikováno v:
Journal of pharmaceutical sciences. 111(9)
Therapeutic IgG mAbs expressed from Chinese hamster ovary (CHO) cells are known to contain three C-terminal variants in their heavy chains, namely, the unprocessed C-terminal lysine, the processed C-terminal lysine, and C-terminal amidation. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5328c4fd8f107a07ec51593d4435001
https://pubmed.ncbi.nlm.nih.gov/35718127
https://pubmed.ncbi.nlm.nih.gov/35718127
Autor:
Laura E, Blue, Xiaoyan, Guan, Marisa K, Joubert, Scott T, Kuhns, Stephanie, Moore, David J, Semin, Mats, Wikström, Jette, Wypych, Chetan T, Goudar
Publikováno v:
Current Opinion in Biotechnology. 78:102800
The biopharmaceutical landscape continues to evolve rapidly, and associated modality complexity and the need to improve molecular understanding require concomitant advances in analytical approaches used to characterize and release the product. The Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e64543094719431cf1a214789f83f4
https://doi.org/10.1016/j.copbio.2022.102800
https://doi.org/10.1016/j.copbio.2022.102800
Publikováno v:
mAbs
Disulfide linkage is critical to protein folding and structural stability. The location of disulfide linkages for antibodies is routinely discovered by comparing the chromatograms of the reduced and non-reduced peptide mapping with location identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355c40abd6c5a1379ec8d2a29bc0c0ab
http://europepmc.org/articles/PMC5973703
http://europepmc.org/articles/PMC5973703
Publikováno v:
mAbs
Sequence variant analysis (SVA) is critical in therapeutic protein development because it ensures the absence of genetic mutations of a production clone or high-level misincorporations during cell culture. While software for searching sequence varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9597dec3a56b014a1cb506ff8bbbe0
https://doi.org/10.1080/19420862.2017.1336591
https://doi.org/10.1080/19420862.2017.1336591
Autor:
Quanzhou Luo, Kenneth W. Walker, Qing Chen, Kannan Gunasekaran, Riki Stevenson, Jie Wen, Frederick W. Jacobsen, Shu-Yin Ho, Lynette Buck, Linda O. Narhi, Kristine M. Daris, Wei Wang, Jette Wypych, Hossein Salimi-Moosavi, Sterling Miller, Ling Liu, Cynthia Li
Publikováno v:
Journal of Biological Chemistry. 292:1865-1875
IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of which isotype to pursue for development of a particular therapeutic antibody important in determining the safety and efficacy of the drug. IgG2 and IgG4 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2cf1364e96ab1f3b6912d3a7576cf4
https://doi.org/10.1074/jbc.m116.748525
https://doi.org/10.1074/jbc.m116.748525