Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jette Wagtberg, Sen"'
Autor:
Mikael Rørdam Andersen, Jette Wagtberg Sen, Yuzhou Fan, Bo Skjold Larsen, Helene Faustrup Kildegaard
Publikováno v:
Biotechnology and Bioengineering. 113:359-366
Therapeutic monoclonal antibodies (mAbs) are mainly produced by heterologous expression in Chinese hamster ovary (CHO) cells. The glycosylation profile of the mAbs has major impact on the efficacy and safety of the drug and is therefore an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1b7dca2ba0b7df198c563a923f0c24
https://doi.org/10.1002/bit.25715
https://doi.org/10.1002/bit.25715
Autor:
Dietmar Weilguny, Christian Müller, Anne Mathilde Lund, Jette Wagtberg Sen, Cleo Kontoravdi, Søren Kofoed Rasmussen, Yuzhou Fan, Ioscani Jimenez del Val, Michael J. Betenbaugh, Mikael Rørdam Andersen, Deniz Baycin-Hizal
Publikováno v:
Biotechnology and Bioengineering. 112:2172-2184
In this study, omics-based analysis tools were used to explore the effect of glucose starvation and culture duration on monoclonal antibody (mAb) production in fed-batch CHO cell culture to gain better insight into how these parameters can be control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf3ff5f631ee5d6f7a7ba698974c7826
https://doi.org/10.1002/bit.25620
https://doi.org/10.1002/bit.25620
Autor:
Ioscani Jimenez del Val, Cleo Kontoravdi, Jette Wagtberg Sen, Søren Kofoed Rasmussen, Yuzhou Fan, Dietmar Weilguny, Christian Müller, Mikael Rørdam Andersen
Publikováno v:
Biotechnology and Bioengineering. 112:521-535
Fed-batch Chinese hamster ovary (CHO) cell culture is the most commonly used process for IgG production in the biopharmaceutical industry. Amino acid and glucose consumption, cell growth, metabolism, antibody titer, and N-glycosylation patterns are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8820f132a264570fd70977e278d3f2db
https://doi.org/10.1002/bit.25450
https://doi.org/10.1002/bit.25450
Autor:
Jette Wagtberg Sen, Mikkel W. Pedersen, Helle Jacobsen, Niels Jorgen Ostergaard Skartved, Thomas Kjærsgaard Jørgensen, Adam S. Hey, Pernille Foged Jensen, Michael Kragh
Publikováno v:
Clinical Cancer Research. 17:5962-5972
Purpose: Sym004 is a novel therapeutic antibody mixture product comprising two unmarketed monoclonal antibodies (mAb) targeting the epidermal growth factor receptor (EGFR). In previous preclinical proof-of-concept studies, Sym004 was shown to elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc79064f982a0334d61db4328ad5e9b
https://doi.org/10.1158/1078-0432.ccr-11-1209
https://doi.org/10.1158/1078-0432.ccr-11-1209
Autor:
Jette Wagtberg Sen, Dietmar Weilguny, Christina R. Andersen, Thomas Tuxen Poulsen, Johan Lantto, Ivan D. Horak, Mikkel W. Pedersen, Michael Kragh, Ida Kjær, Bolette Bjerregaard, Klaus Koefoed, Helle Jacobsen, Anna Dahlman
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(18)
Purpose: Accumulating evidence indicates a high degree of plasticity and compensatory signaling within the human epidermal growth factor receptor (HER) family, leading to resistance upon therapeutic intervention with HER family members. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768031b3f2befbc3e0fd7f2c593b9dc6
https://pubmed.ncbi.nlm.nih.gov/26019173
https://pubmed.ncbi.nlm.nih.gov/26019173
Autor:
Yuzhou, Fan, Ioscani, Jimenez Del Val, Christian, Müller, Anne Mathilde, Lund, Jette Wagtberg, Sen, Søren Kofoed, Rasmussen, Cleo, Kontoravdi, Deniz, Baycin-Hizal, Michael J, Betenbaugh, Dietmar, Weilguny, Mikael Rørdam, Andersen
Publikováno v:
Biotechnology and bioengineering. 112(10)
In this study, omics-based analysis tools were used to explore the effect of glucose starvation and culture duration on monoclonal antibody (mAb) production in fed-batch CHO cell culture to gain better insight into how these parameters can be control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fe24be0436185bf75fe12fa4ccccf78
https://pubmed.ncbi.nlm.nih.gov/25899530
https://pubmed.ncbi.nlm.nih.gov/25899530
Autor:
Yuzhou, Fan, Ioscani, Jimenez Del Val, Christian, Müller, Jette, Wagtberg Sen, Søren Kofoed, Rasmussen, Cleo, Kontoravdi, Dietmar, Weilguny, Mikael Rørdam, Andersen
Publikováno v:
Biotechnology and bioengineering. 112(3)
Fed-batch Chinese hamster ovary (CHO) cell culture is the most commonly used process for IgG production in the biopharmaceutical industry. Amino acid and glucose consumption, cell growth, metabolism, antibody titer, and N-glycosylation patterns are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::123025de00c5269ef479cecbd9715a00
https://pubmed.ncbi.nlm.nih.gov/25220616
https://pubmed.ncbi.nlm.nih.gov/25220616
Autor:
Thomas J. D. Jørgensen, Klaus Koefoed, Pernille Foged Jensen, Jette Wagtberg Sen, Frank Nygaard
Publikováno v:
Jensen, P F, Jørgensen, T J D, Koefoed, K, Nygaard, F & Sen, J W 2013, ' Affinity capture of biotinylated proteins at acidic conditions to facilitate hydrogen/deuterium exchange mass spectrometry analysis of multimeric protein complexes ', Analytical Chemistry, vol. 85, no. 15, pp. 7052-7059 . https://doi.org/10.1021/ac303442y
Characterization of conformational and dynamic changes associated with protein interactions can be done by hydrogen/deuterium exchange mass spectrometry (HDX-MS) by comparing the deuterium uptake in the bound and unbound state of the proteins. Invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7986ad5244448e215c1a467b4bbfde83
https://pubmed.ncbi.nlm.nih.gov/23534402
https://pubmed.ncbi.nlm.nih.gov/23534402
Autor:
Ida Kjær, Michael Kragh, Jette Wagtberg Sen, Bolette Bjerregaard, Mikkel W. Pedersen, Klaus Koefoed, Thomas Tuxen Poulsen, Dietmar Weilguny, Helle Jacobsen, Johan Lantto, Christina R. Andersen, Ivan D. Horak
Publikováno v:
Cancer Research. 73:4751-4751
Deregulation of HER family members plays an important role in the development and progression of human cancer, and EGFR and HER2 are also clinically validated targets in many cancer indications. Accumulating evidence indicates, however, a high degree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af336ac2febc4294a50b42ceb88a7b57
https://doi.org/10.1158/1538-7445.am2013-4751
https://doi.org/10.1158/1538-7445.am2013-4751