Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jette Nowak"'
Autor:
Vivi F. H. Jensen, Anne-Marie Mølck, Jette Nowak, Johannes J. Fels, Jens Lykkesfeldt, Ingrid B. Bøgh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Pancreatic β-cells have an extraordinary ability to adapt to acute fluctuations in glucose levels by rapid changing insulin production to meet metabolic needs. Although acute changes have been characterised, effects of prolonged metabolic s
Externí odkaz:
https://doaj.org/article/e3de2ad81ff644939436faa21a79b44b
Autor:
Vivi F H Jensen, Anne-Marie Mølck, Jette Nowak, Maria Wohlfarth, Eva Nüsken, Damien Demozay, Kai-Dietrich Nüsken, Ingrid B Bøgh
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265988 (2022)
Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutri
Externí odkaz:
https://doaj.org/article/9a0a516057bc45e7af4128d5a8bdcacf
Autor:
Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg
Publikováno v:
Journal of Toxicology, Vol 2017 (2017)
Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in
Externí odkaz:
https://doaj.org/article/ee7952f1805443caa9153dee89120cad
Autor:
Anne-Marie Mølck, Ingrid Sjögren, Jette Nowak, Vivi F. H. Jensen, Inger Thorup, Peter R. Brinck
Publikováno v:
International Journal of Toxicology. 39:560-576
For nonclinical safety-assessment of insulin analogues in vivo, mitogenic effects are compared to that of human insulin. Besides histopathologic evaluation, this usually includes assessment of cell proliferation (CP) in mammary glands. Insulin analog
Autor:
Louise Pedersen, Jette Nowak, Pernille Tveden-Nyborg, Anne Marie Mølck, Birgitte M. Viuff, Jens Lykkesfeldt, Vivi F. H. Jensen, Suzi H. Madsen, Kristina Åkesson, Johannes Josef Fels, Ingrid Brück Bøgh, Fiona E. McGuigan, Charlotte Lund Rasmussen
Publikováno v:
Scientific Reports
Jensen, V F H, Mølck, A-M, Bøgh, I B, Nowak, J, Viuff, B M, Rasmussen, C L M, Pedersen, L, Fels, J J, Madsen, S H, McGuigan, F E, Tveden-Nyborg, P, Lykkesfeldt, J & Akesson, K E 2020, ' Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats ', Scientific Reports, vol. 10, no. 1, 5609 . https://doi.org/10.1038/s41598-020-62554-2
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Jensen, V F H, Mølck, A-M, Bøgh, I B, Nowak, J, Viuff, B M, Rasmussen, C L M, Pedersen, L, Fels, J J, Madsen, S H, McGuigan, F E, Tveden-Nyborg, P, Lykkesfeldt, J & Akesson, K E 2020, ' Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats ', Scientific Reports, vol. 10, no. 1, 5609 . https://doi.org/10.1038/s41598-020-62554-2
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully unde
Autor:
Johannes Josef Fels, Henrik Søeborg, Inger Thorup, Mikala Skydsgaard, Lærke W. Andersen, Hanne Offenberg, Kevin A. Keane, Charlotte M. Dalsgaard, Ingrid Sjögren, Jennifer M. Rojas, Line Olrik Berthelsen, Jette Nowak, Florian Bolze, Jes Tovborg Jensen, Majken Dalgaard
Publikováno v:
Toxicologic Pathology. 46:777-798
The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of ant
Autor:
Anne-Marie Mølck, Vivi F. H. Jensen, Jette Nowak, Ingrid Brück Bøgh, Henrik Søeborg, Melissa Chapman, Jens Lykkesfeldt
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 122:165-175
Peripheral neuropathy is one of the most common complications of diabetic hyperglycaemia. Insulin-induced hypoglycaemia (IIH) might potentially exacerbate or contribute to neuropathy as hypoglycaemia also causes peripheral neuropathy. In rats, IIH in
Autor:
Julie M. Larsen, Kai Chiu Liu, David Bell, Thomas Krogh-Meibom, Emma Moore, Jette Nowak, Nanna Skall Sorensen, Wendela A. Kappers, Caroline E. Rasmussen, Hanne Offenberg
Publikováno v:
Journal of Toxicology, Vol 2017 (2017)
Journal of Toxicology
Journal of Toxicology
Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in
Autor:
Hanne Offenberg, Julie M. Larsen, Alison Rowles, Caroline E. Rasmussen, Jette Nowak, Anna L. Bottomley
Publikováno v:
Toxicologic pathology. 44(5)
Nonacog beta pegol is a 40-kDa polyethylene glycosylated (PEGylated) human recombinant coagulation factor IX, intended for the treatment of hemophilia B. Human coagulation factors are immunogenic in animals; therefore, to evaluate the long-term toxic
Autor:
Lotte, Bjerre Knudsen, Lars Wichmann, Madsen, Søren, Andersen, Kasper, Almholt, Anne S, de Boer, Daniel J, Drucker, Carsten, Gotfredsen, Frederikke Lihme, Egerod, Anne Charlotte, Hegelund, Helene, Jacobsen, Søren Dyring, Jacobsen, Alan C, Moses, Anne-Marie, Mølck, Henriette S, Nielsen, Jette, Nowak, Helene, Solberg, Tu D L, Thi, Milan, Zdravkovic, Ulrik, Moerch
Publikováno v:
Endocrinology. 151:1473-1486
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid C-cell hyperplasia and tumors. Here, we report data supporting a GLP-1 receptor-mediated mech