Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jette B. Boll"'
Publikováno v:
Journal of Applied Toxicology. 36:1430-1436
The selection of a vehicle for oral formulations of compounds to be used in non-clinical safety studies is a challenge for poorly soluble compounds. Typically a compromise between solubility and tolerability has to be reached. Vehicle tolerability da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70432f4245ea3cf849b1724f7704b481
https://doi.org/10.1002/jat.3296
https://doi.org/10.1002/jat.3296
Autor:
Jette B. Boll, Kim Dekermendjian, Christoffer Bundgaard, Anette Graven Sams, Kristen Frederiksen, Jesper F. Bastlund, Roger L. Papke, John Paul Redrobe, Jørgen Eskildsen, Morten Laursen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:288-293
In this Letter, we describe a chemical lead optimization campaign starting from a novel, weak α7 nicotinic acetylcholine receptor positive allosteric modulator (PAM) hit from a HTS screen. Exploration of the structure-activity relationships for α7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7a1a7146aa58a70bcd87d6c19bf5e
https://doi.org/10.1016/j.bmcl.2013.11.022
https://doi.org/10.1016/j.bmcl.2013.11.022
Publikováno v:
Journal of applied toxicology : JAT. 36(11)
The selection of a vehicle for oral formulations of compounds to be used in non-clinical safety studies is a challenge for poorly soluble compounds. Typically a compromise between solubility and tolerability has to be reached. Vehicle tolerability da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::870b3dfbbaef79ed777a39816959a8d9
https://pubmed.ncbi.nlm.nih.gov/26849184
https://pubmed.ncbi.nlm.nih.gov/26849184
Autor:
Henrik Tønsberg, René Holm, Jette B. Boll, Anette Müllertz, Jette Bredahl Jacobsen, Huiling Mu
Publikováno v:
The Journal of pharmacy and pharmacology. 63(6)
Objectives The aim of this study was to examine the effects of bile on the oral absorption of the poorly water-soluble compound, halofantrine, when administered to rats in vehicles consisting of the co-solvent polyethylene glycol 400 (PEG 400) alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c00834c1cbe656bd62707913128be1
https://pubmed.ncbi.nlm.nih.gov/21585380
https://pubmed.ncbi.nlm.nih.gov/21585380
Autor:
René Holm, Anette Müllertz, Henrik Tønsberg, Jette B. Boll, T G Bjerregaard, Jette Bredahl Jacobsen
Publikováno v:
Laboratory animals. 44(4)
The single bile duct cannulated rat model was used for short-term intestinal absorption studies. Rats were randomly assigned to three groups: (A) bile duct cannulated, (B) control laparotomy and (C) no treatment. The body weight and health of the rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24148f7b85565a5df177e237c0e79d5
https://pubmed.ncbi.nlm.nih.gov/20736319
https://pubmed.ncbi.nlm.nih.gov/20736319